1XK4

Crystal structure of human calprotectin(S100A8/S100A9)

Summary for 1XK4

• Entry DOI: 10.2210/pdb1xk4/pdb
• Related: 1irj 1mr8
• Descriptor: Calgranulin A, Calgranulin B, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: s100 family, heterotetramer, metal binding protein
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P05109 P06702
• Total number of polymer chains: 12
• Total formula weight: 145018.12

Authors

Korndoerfer, I.P.,Brueckner, F.,Skerra, A. (deposition date: 2004-09-26, release date: 2005-10-18, Last modification date: 2023-10-25)

• Primary citation: Korndoerfer, I.P.,Brueckner, F.,Skerra, A.; The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins; J.Mol.Biol., 370:887-898, 2007; PubMed: 17553524; DOI: 10.1016/j.jmb.2007.04.065

Experimental method

X-RAY DIFFRACTION (1.8 Å)