1XK4

Crystal structure of human calprotectin(S100A8/S100A9)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002523	biological_process	leukocyte migration involved in inflammatory response
A	0002544	biological_process	chronic inflammatory response
A	0002790	biological_process	peptide secretion
A	0002793	biological_process	positive regulation of peptide secretion
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0008017	molecular_function	microtubule binding
A	0008270	molecular_function	zinc ion binding
A	0010043	biological_process	response to zinc ion
A	0014002	biological_process	astrocyte development
A	0018119	biological_process	peptidyl-cysteine S-nitrosylation
A	0030307	biological_process	positive regulation of cell growth
A	0030593	biological_process	neutrophil chemotaxis
A	0032119	biological_process	sequestering of zinc ion
A	0032496	biological_process	response to lipopolysaccharide
A	0034121	biological_process	regulation of toll-like receptor signaling pathway
A	0034774	cellular_component	secretory granule lumen
A	0035425	biological_process	autocrine signaling
A	0035662	molecular_function	Toll-like receptor 4 binding
A	0042742	biological_process	defense response to bacterium
A	0045087	biological_process	innate immune response
A	0045111	cellular_component	intermediate filament cytoskeleton
A	0045471	biological_process	response to ethanol
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050544	molecular_function	arachidonic acid binding
A	0050729	biological_process	positive regulation of inflammatory response
A	0050786	molecular_function	RAGE receptor binding
A	0050832	biological_process	defense response to fungus
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051493	biological_process	regulation of cytoskeleton organization
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
A	0070488	biological_process	neutrophil aggregation
A	1990660	cellular_component	calprotectin complex
A	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
B	0002523	biological_process	leukocyte migration involved in inflammatory response
B	0002544	biological_process	chronic inflammatory response
B	0002790	biological_process	peptide secretion
B	0002793	biological_process	positive regulation of peptide secretion
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0006914	biological_process	autophagy
B	0006915	biological_process	apoptotic process
B	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
B	0006935	biological_process	chemotaxis
B	0006954	biological_process	inflammatory response
B	0008017	molecular_function	microtubule binding
B	0008270	molecular_function	zinc ion binding
B	0010043	biological_process	response to zinc ion
B	0014002	biological_process	astrocyte development
B	0018119	biological_process	peptidyl-cysteine S-nitrosylation
B	0030307	biological_process	positive regulation of cell growth
B	0030593	biological_process	neutrophil chemotaxis
B	0032119	biological_process	sequestering of zinc ion
B	0032496	biological_process	response to lipopolysaccharide
B	0034121	biological_process	regulation of toll-like receptor signaling pathway
B	0034774	cellular_component	secretory granule lumen
B	0035425	biological_process	autocrine signaling
B	0035662	molecular_function	Toll-like receptor 4 binding
B	0042742	biological_process	defense response to bacterium
B	0045087	biological_process	innate immune response
B	0045111	cellular_component	intermediate filament cytoskeleton
B	0045471	biological_process	response to ethanol
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050544	molecular_function	arachidonic acid binding
B	0050729	biological_process	positive regulation of inflammatory response
B	0050786	molecular_function	RAGE receptor binding
B	0050832	biological_process	defense response to fungus
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051493	biological_process	regulation of cytoskeleton organization
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0070062	cellular_component	extracellular exosome
B	0070488	biological_process	neutrophil aggregation
B	1990660	cellular_component	calprotectin complex
B	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
C	0002523	biological_process	leukocyte migration involved in inflammatory response
C	0002544	biological_process	chronic inflammatory response
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0007267	biological_process	cell-cell signaling
C	0008017	molecular_function	microtubule binding
C	0008270	molecular_function	zinc ion binding
C	0010976	biological_process	positive regulation of neuron projection development
C	0014002	biological_process	astrocyte development
C	0016209	molecular_function	antioxidant activity
C	0030307	biological_process	positive regulation of cell growth
C	0030593	biological_process	neutrophil chemotaxis
C	0032119	biological_process	sequestering of zinc ion
C	0032496	biological_process	response to lipopolysaccharide
C	0034121	biological_process	regulation of toll-like receptor signaling pathway
C	0034774	cellular_component	secretory granule lumen
C	0035425	biological_process	autocrine signaling
C	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
C	0035662	molecular_function	Toll-like receptor 4 binding
C	0035821	biological_process	modulation of process of another organism
C	0042742	biological_process	defense response to bacterium
C	0043542	biological_process	endothelial cell migration
C	0045087	biological_process	innate immune response
C	0045113	biological_process	regulation of integrin biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050544	molecular_function	arachidonic acid binding
C	0050729	biological_process	positive regulation of inflammatory response
C	0050786	molecular_function	RAGE receptor binding
C	0050832	biological_process	defense response to fungus
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051493	biological_process	regulation of cytoskeleton organization
C	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070062	cellular_component	extracellular exosome
C	0070488	biological_process	neutrophil aggregation
C	0098869	biological_process	cellular oxidant detoxification
C	1990660	cellular_component	calprotectin complex
C	1990662	cellular_component	S100A9 complex
C	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
D	0002523	biological_process	leukocyte migration involved in inflammatory response
D	0002544	biological_process	chronic inflammatory response
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0006914	biological_process	autophagy
D	0006915	biological_process	apoptotic process
D	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
D	0006935	biological_process	chemotaxis
D	0006954	biological_process	inflammatory response
D	0007267	biological_process	cell-cell signaling
D	0008017	molecular_function	microtubule binding
D	0008270	molecular_function	zinc ion binding
D	0010976	biological_process	positive regulation of neuron projection development
D	0014002	biological_process	astrocyte development
D	0016209	molecular_function	antioxidant activity
D	0030307	biological_process	positive regulation of cell growth
D	0030593	biological_process	neutrophil chemotaxis
D	0032119	biological_process	sequestering of zinc ion
D	0032496	biological_process	response to lipopolysaccharide
D	0034121	biological_process	regulation of toll-like receptor signaling pathway
D	0034774	cellular_component	secretory granule lumen
D	0035425	biological_process	autocrine signaling
D	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
D	0035662	molecular_function	Toll-like receptor 4 binding
D	0035821	biological_process	modulation of process of another organism
D	0042742	biological_process	defense response to bacterium
D	0043542	biological_process	endothelial cell migration
D	0045087	biological_process	innate immune response
D	0045113	biological_process	regulation of integrin biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050544	molecular_function	arachidonic acid binding
D	0050729	biological_process	positive regulation of inflammatory response
D	0050786	molecular_function	RAGE receptor binding
D	0050832	biological_process	defense response to fungus
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0051493	biological_process	regulation of cytoskeleton organization
D	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0062023	cellular_component	collagen-containing extracellular matrix
D	0070062	cellular_component	extracellular exosome
D	0070488	biological_process	neutrophil aggregation
D	0098869	biological_process	cellular oxidant detoxification
D	1990660	cellular_component	calprotectin complex
D	1990662	cellular_component	S100A9 complex
D	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
E	0002523	biological_process	leukocyte migration involved in inflammatory response
E	0002544	biological_process	chronic inflammatory response
E	0002790	biological_process	peptide secretion
E	0002793	biological_process	positive regulation of peptide secretion
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0006914	biological_process	autophagy
E	0006915	biological_process	apoptotic process
E	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
E	0006935	biological_process	chemotaxis
E	0006954	biological_process	inflammatory response
E	0008017	molecular_function	microtubule binding
E	0008270	molecular_function	zinc ion binding
E	0010043	biological_process	response to zinc ion
E	0014002	biological_process	astrocyte development
E	0018119	biological_process	peptidyl-cysteine S-nitrosylation
E	0030307	biological_process	positive regulation of cell growth
E	0030593	biological_process	neutrophil chemotaxis
E	0032119	biological_process	sequestering of zinc ion
E	0032496	biological_process	response to lipopolysaccharide
E	0034121	biological_process	regulation of toll-like receptor signaling pathway
E	0034774	cellular_component	secretory granule lumen
E	0035425	biological_process	autocrine signaling
E	0035662	molecular_function	Toll-like receptor 4 binding
E	0042742	biological_process	defense response to bacterium
E	0045087	biological_process	innate immune response
E	0045111	cellular_component	intermediate filament cytoskeleton
E	0045471	biological_process	response to ethanol
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050544	molecular_function	arachidonic acid binding
E	0050729	biological_process	positive regulation of inflammatory response
E	0050786	molecular_function	RAGE receptor binding
E	0050832	biological_process	defense response to fungus
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0051493	biological_process	regulation of cytoskeleton organization
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070062	cellular_component	extracellular exosome
E	0070488	biological_process	neutrophil aggregation
E	1990660	cellular_component	calprotectin complex
E	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
F	0002523	biological_process	leukocyte migration involved in inflammatory response
F	0002544	biological_process	chronic inflammatory response
F	0002790	biological_process	peptide secretion
F	0002793	biological_process	positive regulation of peptide secretion
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0006914	biological_process	autophagy
F	0006915	biological_process	apoptotic process
F	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
F	0006935	biological_process	chemotaxis
F	0006954	biological_process	inflammatory response
F	0008017	molecular_function	microtubule binding
F	0008270	molecular_function	zinc ion binding
F	0010043	biological_process	response to zinc ion
F	0014002	biological_process	astrocyte development
F	0018119	biological_process	peptidyl-cysteine S-nitrosylation
F	0030307	biological_process	positive regulation of cell growth
F	0030593	biological_process	neutrophil chemotaxis
F	0032119	biological_process	sequestering of zinc ion
F	0032496	biological_process	response to lipopolysaccharide
F	0034121	biological_process	regulation of toll-like receptor signaling pathway
F	0034774	cellular_component	secretory granule lumen
F	0035425	biological_process	autocrine signaling
F	0035662	molecular_function	Toll-like receptor 4 binding
F	0042742	biological_process	defense response to bacterium
F	0045087	biological_process	innate immune response
F	0045111	cellular_component	intermediate filament cytoskeleton
F	0045471	biological_process	response to ethanol
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050544	molecular_function	arachidonic acid binding
F	0050729	biological_process	positive regulation of inflammatory response
F	0050786	molecular_function	RAGE receptor binding
F	0050832	biological_process	defense response to fungus
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0051493	biological_process	regulation of cytoskeleton organization
F	0062023	cellular_component	collagen-containing extracellular matrix
F	0070062	cellular_component	extracellular exosome
F	0070488	biological_process	neutrophil aggregation
F	1990660	cellular_component	calprotectin complex
F	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
G	0002523	biological_process	leukocyte migration involved in inflammatory response
G	0002544	biological_process	chronic inflammatory response
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0006914	biological_process	autophagy
G	0006915	biological_process	apoptotic process
G	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
G	0006935	biological_process	chemotaxis
G	0006954	biological_process	inflammatory response
G	0007267	biological_process	cell-cell signaling
G	0008017	molecular_function	microtubule binding
G	0008270	molecular_function	zinc ion binding
G	0010976	biological_process	positive regulation of neuron projection development
G	0014002	biological_process	astrocyte development
G	0016209	molecular_function	antioxidant activity
G	0030307	biological_process	positive regulation of cell growth
G	0030593	biological_process	neutrophil chemotaxis
G	0032119	biological_process	sequestering of zinc ion
G	0032496	biological_process	response to lipopolysaccharide
G	0034121	biological_process	regulation of toll-like receptor signaling pathway
G	0034774	cellular_component	secretory granule lumen
G	0035425	biological_process	autocrine signaling
G	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
G	0035662	molecular_function	Toll-like receptor 4 binding
G	0035821	biological_process	modulation of process of another organism
G	0042742	biological_process	defense response to bacterium
G	0043542	biological_process	endothelial cell migration
G	0045087	biological_process	innate immune response
G	0045113	biological_process	regulation of integrin biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0050544	molecular_function	arachidonic acid binding
G	0050729	biological_process	positive regulation of inflammatory response
G	0050786	molecular_function	RAGE receptor binding
G	0050832	biological_process	defense response to fungus
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051493	biological_process	regulation of cytoskeleton organization
G	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
G	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
G	0062023	cellular_component	collagen-containing extracellular matrix
G	0070062	cellular_component	extracellular exosome
G	0070488	biological_process	neutrophil aggregation
G	0098869	biological_process	cellular oxidant detoxification
G	1990660	cellular_component	calprotectin complex
G	1990662	cellular_component	S100A9 complex
G	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
H	0002523	biological_process	leukocyte migration involved in inflammatory response
H	0002544	biological_process	chronic inflammatory response
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0006914	biological_process	autophagy
H	0006915	biological_process	apoptotic process
H	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
H	0006935	biological_process	chemotaxis
H	0006954	biological_process	inflammatory response
H	0007267	biological_process	cell-cell signaling
H	0008017	molecular_function	microtubule binding
H	0008270	molecular_function	zinc ion binding
H	0010976	biological_process	positive regulation of neuron projection development
H	0014002	biological_process	astrocyte development
H	0016209	molecular_function	antioxidant activity
H	0030307	biological_process	positive regulation of cell growth
H	0030593	biological_process	neutrophil chemotaxis
H	0032119	biological_process	sequestering of zinc ion
H	0032496	biological_process	response to lipopolysaccharide
H	0034121	biological_process	regulation of toll-like receptor signaling pathway
H	0034774	cellular_component	secretory granule lumen
H	0035425	biological_process	autocrine signaling
H	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
H	0035662	molecular_function	Toll-like receptor 4 binding
H	0035821	biological_process	modulation of process of another organism
H	0042742	biological_process	defense response to bacterium
H	0043542	biological_process	endothelial cell migration
H	0045087	biological_process	innate immune response
H	0045113	biological_process	regulation of integrin biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050544	molecular_function	arachidonic acid binding
H	0050729	biological_process	positive regulation of inflammatory response
H	0050786	molecular_function	RAGE receptor binding
H	0050832	biological_process	defense response to fungus
H	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
H	0051493	biological_process	regulation of cytoskeleton organization
H	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0062023	cellular_component	collagen-containing extracellular matrix
H	0070062	cellular_component	extracellular exosome
H	0070488	biological_process	neutrophil aggregation
H	0098869	biological_process	cellular oxidant detoxification
H	1990660	cellular_component	calprotectin complex
H	1990662	cellular_component	S100A9 complex
H	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
I	0002523	biological_process	leukocyte migration involved in inflammatory response
I	0002544	biological_process	chronic inflammatory response
I	0002790	biological_process	peptide secretion
I	0002793	biological_process	positive regulation of peptide secretion
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0006914	biological_process	autophagy
I	0006915	biological_process	apoptotic process
I	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
I	0006935	biological_process	chemotaxis
I	0006954	biological_process	inflammatory response
I	0008017	molecular_function	microtubule binding
I	0008270	molecular_function	zinc ion binding
I	0010043	biological_process	response to zinc ion
I	0014002	biological_process	astrocyte development
I	0018119	biological_process	peptidyl-cysteine S-nitrosylation
I	0030307	biological_process	positive regulation of cell growth
I	0030593	biological_process	neutrophil chemotaxis
I	0032119	biological_process	sequestering of zinc ion
I	0032496	biological_process	response to lipopolysaccharide
I	0034121	biological_process	regulation of toll-like receptor signaling pathway
I	0034774	cellular_component	secretory granule lumen
I	0035425	biological_process	autocrine signaling
I	0035662	molecular_function	Toll-like receptor 4 binding
I	0042742	biological_process	defense response to bacterium
I	0045087	biological_process	innate immune response
I	0045111	cellular_component	intermediate filament cytoskeleton
I	0045471	biological_process	response to ethanol
I	0046872	molecular_function	metal ion binding
I	0048306	molecular_function	calcium-dependent protein binding
I	0050544	molecular_function	arachidonic acid binding
I	0050729	biological_process	positive regulation of inflammatory response
I	0050786	molecular_function	RAGE receptor binding
I	0050832	biological_process	defense response to fungus
I	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
I	0051493	biological_process	regulation of cytoskeleton organization
I	0062023	cellular_component	collagen-containing extracellular matrix
I	0070062	cellular_component	extracellular exosome
I	0070488	biological_process	neutrophil aggregation
I	1990660	cellular_component	calprotectin complex
I	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
J	0002523	biological_process	leukocyte migration involved in inflammatory response
J	0002544	biological_process	chronic inflammatory response
J	0002790	biological_process	peptide secretion
J	0002793	biological_process	positive regulation of peptide secretion
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005886	cellular_component	plasma membrane
J	0006914	biological_process	autophagy
J	0006915	biological_process	apoptotic process
J	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
J	0006935	biological_process	chemotaxis
J	0006954	biological_process	inflammatory response
J	0008017	molecular_function	microtubule binding
J	0008270	molecular_function	zinc ion binding
J	0010043	biological_process	response to zinc ion
J	0014002	biological_process	astrocyte development
J	0018119	biological_process	peptidyl-cysteine S-nitrosylation
J	0030307	biological_process	positive regulation of cell growth
J	0030593	biological_process	neutrophil chemotaxis
J	0032119	biological_process	sequestering of zinc ion
J	0032496	biological_process	response to lipopolysaccharide
J	0034121	biological_process	regulation of toll-like receptor signaling pathway
J	0034774	cellular_component	secretory granule lumen
J	0035425	biological_process	autocrine signaling
J	0035662	molecular_function	Toll-like receptor 4 binding
J	0042742	biological_process	defense response to bacterium
J	0045087	biological_process	innate immune response
J	0045111	cellular_component	intermediate filament cytoskeleton
J	0045471	biological_process	response to ethanol
J	0046872	molecular_function	metal ion binding
J	0048306	molecular_function	calcium-dependent protein binding
J	0050544	molecular_function	arachidonic acid binding
J	0050729	biological_process	positive regulation of inflammatory response
J	0050786	molecular_function	RAGE receptor binding
J	0050832	biological_process	defense response to fungus
J	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
J	0051493	biological_process	regulation of cytoskeleton organization
J	0062023	cellular_component	collagen-containing extracellular matrix
J	0070062	cellular_component	extracellular exosome
J	0070488	biological_process	neutrophil aggregation
J	1990660	cellular_component	calprotectin complex
J	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
K	0002523	biological_process	leukocyte migration involved in inflammatory response
K	0002544	biological_process	chronic inflammatory response
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005886	cellular_component	plasma membrane
K	0006914	biological_process	autophagy
K	0006915	biological_process	apoptotic process
K	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
K	0006935	biological_process	chemotaxis
K	0006954	biological_process	inflammatory response
K	0007267	biological_process	cell-cell signaling
K	0008017	molecular_function	microtubule binding
K	0008270	molecular_function	zinc ion binding
K	0010976	biological_process	positive regulation of neuron projection development
K	0014002	biological_process	astrocyte development
K	0016209	molecular_function	antioxidant activity
K	0030307	biological_process	positive regulation of cell growth
K	0030593	biological_process	neutrophil chemotaxis
K	0032119	biological_process	sequestering of zinc ion
K	0032496	biological_process	response to lipopolysaccharide
K	0034121	biological_process	regulation of toll-like receptor signaling pathway
K	0034774	cellular_component	secretory granule lumen
K	0035425	biological_process	autocrine signaling
K	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
K	0035662	molecular_function	Toll-like receptor 4 binding
K	0035821	biological_process	modulation of process of another organism
K	0042742	biological_process	defense response to bacterium
K	0043542	biological_process	endothelial cell migration
K	0045087	biological_process	innate immune response
K	0045113	biological_process	regulation of integrin biosynthetic process
K	0046872	molecular_function	metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0050544	molecular_function	arachidonic acid binding
K	0050729	biological_process	positive regulation of inflammatory response
K	0050786	molecular_function	RAGE receptor binding
K	0050832	biological_process	defense response to fungus
K	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
K	0051493	biological_process	regulation of cytoskeleton organization
K	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
K	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0062023	cellular_component	collagen-containing extracellular matrix
K	0070062	cellular_component	extracellular exosome
K	0070488	biological_process	neutrophil aggregation
K	0098869	biological_process	cellular oxidant detoxification
K	1990660	cellular_component	calprotectin complex
K	1990662	cellular_component	S100A9 complex
K	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
L	0002523	biological_process	leukocyte migration involved in inflammatory response
L	0002544	biological_process	chronic inflammatory response
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0006914	biological_process	autophagy
L	0006915	biological_process	apoptotic process
L	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
L	0006935	biological_process	chemotaxis
L	0006954	biological_process	inflammatory response
L	0007267	biological_process	cell-cell signaling
L	0008017	molecular_function	microtubule binding
L	0008270	molecular_function	zinc ion binding
L	0010976	biological_process	positive regulation of neuron projection development
L	0014002	biological_process	astrocyte development
L	0016209	molecular_function	antioxidant activity
L	0030307	biological_process	positive regulation of cell growth
L	0030593	biological_process	neutrophil chemotaxis
L	0032119	biological_process	sequestering of zinc ion
L	0032496	biological_process	response to lipopolysaccharide
L	0034121	biological_process	regulation of toll-like receptor signaling pathway
L	0034774	cellular_component	secretory granule lumen
L	0035425	biological_process	autocrine signaling
L	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
L	0035662	molecular_function	Toll-like receptor 4 binding
L	0035821	biological_process	modulation of process of another organism
L	0042742	biological_process	defense response to bacterium
L	0043542	biological_process	endothelial cell migration
L	0045087	biological_process	innate immune response
L	0045113	biological_process	regulation of integrin biosynthetic process
L	0046872	molecular_function	metal ion binding
L	0048306	molecular_function	calcium-dependent protein binding
L	0050544	molecular_function	arachidonic acid binding
L	0050729	biological_process	positive regulation of inflammatory response
L	0050786	molecular_function	RAGE receptor binding
L	0050832	biological_process	defense response to fungus
L	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
L	0051493	biological_process	regulation of cytoskeleton organization
L	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
L	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
L	0062023	cellular_component	collagen-containing extracellular matrix
L	0070062	cellular_component	extracellular exosome
L	0070488	biological_process	neutrophil aggregation
L	0098869	biological_process	cellular oxidant detoxification
L	1990660	cellular_component	calprotectin complex
L	1990662	cellular_component	S100A9 complex
L	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1501

Chain	Residue
A	ASP59
A	ASN61
A	ASP63
A	ALA65
A	GLU70
A	HOH2076

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1502

Chain	Residue
A	ALA28
A	TYR30
A	HOH2087
A	SER20
A	LYS23
A	ASN25

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 2501

Chain	Residue
B	ASP59
B	ASN61
B	ASP63
B	ALA65
B	GLU70
B	HOH2565

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 2502

Chain	Residue
B	SER20
B	LYS23
B	ASN25
B	ALA28
B	TYR30
B	HOH2580

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 3501

Chain	Residue
C	ASP67
C	ASN69
C	ASP71
C	GLN73
C	GLU78
C	HOH3615

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 3502

Chain	Residue
C	SER23
C	LEU26
C	HIS28
C	THR31
C	GLU36
C	HOH3614

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 4501

Chain	Residue
D	ASP67
D	ASN69
D	ASP71
D	GLN73
D	GLU78
D	HOH4579

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 4502

Chain	Residue
D	SER23
D	LEU26
D	HIS28
D	THR31
D	GLU36
D	HOH4568

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1511

Chain	Residue
E	ASP59
E	ASN61
E	ASP63
E	ALA65
E	GLU70
E	HOH1605

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1512

Chain	Residue
E	SER20
E	LYS23
E	ASN25
E	ALA28
E	TYR30
E	HOH1604

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 2511

Chain	Residue
F	ASP59
F	ASN61
F	ASP63
F	ALA65
F	GLU70
F	HOH2578

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 2512

Chain	Residue
F	SER20
F	LYS23
F	ASN25
F	ALA28
F	TYR30
F	HOH2597

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 3511

Chain	Residue
G	ASP67
G	ASN69
G	ASP71
G	GLN73
G	GLU78
G	HOH3574

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 3512

Chain	Residue
G	SER23
G	LEU26
G	HIS28
G	THR31
G	GLU36
G	HOH3549

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 4511

Chain	Residue
H	ASP67
H	ASN69
H	ASP71
H	GLN73
H	GLU78
H	HOH4569

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 4512

Chain	Residue
H	SER23
H	LEU26
H	HIS28
H	THR31
H	GLU36
H	HOH4592

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 1521

Chain	Residue
I	ALA65
I	GLU70
I	HOH1598
I	ASP59
I	ASN61
I	ASP63

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 1522

Chain	Residue
I	SER20
I	LYS23
I	ASN25
I	ALA28
I	TYR30
I	HOH1596

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 2521

Chain	Residue
J	ASP59
J	ASN61
J	ASP63
J	ALA65
J	GLU70
J	HOH2607

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 2522

Chain	Residue
J	SER20
J	LYS23
J	ASN25
J	ALA28
J	TYR30
J	HOH2610

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA K 3521

Chain	Residue
K	ASP67
K	ASN69
K	ASP71
K	GLN73
K	GLU78
K	HOH3595

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA K 3522

Chain	Residue
K	SER23
K	LEU26
K	HIS28
K	THR31
K	GLU36
K	HOH3596

---

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 4521

Chain	Residue
L	ASP67
L	ASN69
L	ASP71
L	GLN73
L	GLU78
L	HOH4599

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 4522

Chain	Residue
L	SER23
L	LEU26
L	HIS28
L	THR31
L	GLU36
L	HOH4595

---

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL J 2007

Chain	Residue
J	HOH2528

---

site_id	CC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC F 2008

Chain	Residue
F	THR3
F	GLU4
F	HOH2593
H	TYR22
H	ASP44
H	HOH4558
J	THR3
J	GLU4
L	LYS43
L	ASP44
L	HOH4605

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DTNADKQLSfeEF

Chain	Residue	Details
C	ASP67-PHE79
A	ASP59-PHE71

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. IMedLDtnaDkqlSFeEFimLM

Chain	Residue	Details
C	ILE62-MET83
A	TRP54-VAL75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000305|PubMed:17553524

Chain	Residue	Details
C	HIS20
G	ASP30
G	HIS91
G	HIS95
H	HIS20
H	ASP30
H	HIS91
H	HIS95
K	HIS20
K	ASP30
K	HIS91
C	ASP30
K	HIS95
L	HIS20
L	ASP30
L	HIS91
L	HIS95
I	HIS87
J	HIS17
J	HIS27
J	ASP33
J	HIS83
C	HIS91
J	HIS87
C	HIS95
D	HIS20
D	ASP30
D	HIS91
D	HIS95
G	HIS20

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	BINDING: BINDING => ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4

Chain	Residue	Details
C	SER23
D	GLU36
G	SER23
G	LEU26
G	HIS28
G	THR31
G	GLU36
H	SER23
H	LEU26
H	HIS28
H	THR31
C	LEU26
H	GLU36
K	SER23
K	LEU26
K	HIS28
K	THR31
K	GLU36
L	SER23
L	LEU26
L	HIS28
L	THR31
C	HIS28
L	GLU36
C	THR31
C	GLU36
D	SER23
D	LEU26
D	HIS28
D	THR31

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4

Chain	Residue	Details
C	ASP67
D	GLU78
G	ASP67
G	ASN69
G	ASP71
G	GLN73
G	GLU78
H	ASP67
H	ASN69
H	ASP71
H	GLN73
C	ASN69
H	GLU78
K	ASP67
K	ASN69
K	ASP71
K	GLN73
K	GLU78
L	ASP67
L	ASN69
L	ASP71
L	GLN73
C	ASP71
L	GLU78
C	GLN73
C	GLU78
D	ASP67
D	ASN69
D	ASP71
D	GLN73

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Blocked amino end (Thr)

Chain	Residue	Details
C	THR2
D	THR2
G	THR2
H	THR2
K	THR2
L	THR2

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: S-nitrosocysteine; transient => ECO:0000305|PubMed:25417112

Chain	Residue	Details
C	SER3
D	SER3
G	SER3
H	SER3
K	SER3
L	SER3

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Pros-methylhistidine => ECO:0000250|UniProtKB:P50116

Chain	Residue	Details
C	HIS105
D	HIS105
G	HIS105
H	HIS105
K	HIS105
L	HIS105

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:2478889, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:19367720, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	THR113
D	THR113
G	THR113
H	THR113
K	THR113
L	THR113

---