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PDB: 98 件
6ZVF
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BU of 6zvf by Molmil
Crystal structure of the recombinant Fab fragment derived from the hybridoma M3/38 in complex with a human Galectin-3 peptide
分子名称: Chimeric Fab M3/38 (L,H), Galectin-3
著者Skerra, A, Eichinger, A.
登録日2020-07-24
公開日2021-04-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo.
Sci Rep, 11, 2021
6GR0
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BU of 6gr0 by Molmil
Petrobactin-binding engineered lipocalin in complex with gallium-petrobactin
分子名称: 4-[4-[3-[[3,4-bis(oxidanyl)phenyl]carbonylamino]propylamino]butylamino]-2-[2-[4-[3-[[3,4-bis(oxidanyl)phenyl]carbonylamino]propylamino]butylamino]-2-oxidanylidene-ethyl]-2-oxidanyl-4-oxidanylidene-butanoic acid, GALLIUM (III) ION, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2018-06-08
公開日2018-08-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus.
Angew. Chem. Int. Ed. Engl., 57, 2018
6GQZ
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BU of 6gqz by Molmil
Petrobactin-binding engineered lipocalin without ligand
分子名称: Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2018-06-08
公開日2018-08-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus.
Angew. Chem. Int. Ed. Engl., 57, 2018
6QBB
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BU of 6qbb by Molmil
Engineered streptavidin variant (ENAGY) in complex with the Strep-tag II peptide
分子名称: Strep-tag II peptide, Streptavidin
著者Skerra, A, Eichinger, A.
登録日2018-12-20
公開日2020-01-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6QSY
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BU of 6qsy by Molmil
Engineered streptavidin variant (H--WY) in complex with the Strep-tag II peptide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Strep-tag II peptide, Streptavidin, ...
著者Skerra, A, Eichinger, A.
登録日2019-02-22
公開日2020-03-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6QW4
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BU of 6qw4 by Molmil
Engineered streptavidin variant (ACGR) in complex with the Strep-tag II peptide
分子名称: Strep-tag II peptide, Streptavidin
著者Skerra, A, Eichinger, A.
登録日2019-03-05
公開日2020-03-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6QMU
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BU of 6qmu by Molmil
A tetrahedral boronic acid diester formed by a non-natural amino acid in the ligand pocket of an engineered lipocalin
分子名称: 3-nitrophenol, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2019-02-08
公開日2019-08-28
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献A Tetrahedral Boronic Acid Diester Formed by an Unnatural Amino Acid in the Ligand Pocket of an Engineered Lipocalin.
Chembiochem, 21, 2020
6Z2C
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BU of 6z2c by Molmil
Engineered lipocalin C3A5 in complex with a transition state analog
分子名称: 1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2020-05-15
公開日2021-05-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of an engineered lipocalin that catalyzes a Diels-Alder reaction
To be published
6Z6Z
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BU of 6z6z by Molmil
Crystal structure of an Anticalin directed towards colchicine without ligand
分子名称: CALCIUM ION, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2020-05-29
公開日2021-06-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural rearrangement in the ligand pocket of Colchicalin upon Colchicine binding
To be published
3P7G
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BU of 3p7g by Molmil
Structure of the human Langerin carbohydrate recognition domain in complex with mannose
分子名称: C-type lectin domain family 4 member K, CALCIUM ION, alpha-D-mannopyranose
著者Skerra, A, Schiefner, A.
登録日2010-10-12
公開日2010-11-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site.
Mol.Immunol., 45, 2008
3P7F
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BU of 3p7f by Molmil
Structure of the human Langerin carbohydrate recognition domain
分子名称: C-type lectin domain family 4 member K, CALCIUM ION
著者Skerra, A, Schiefner, A.
登録日2010-10-12
公開日2010-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site.
Mol.Immunol., 45, 2008
3P7H
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BU of 3p7h by Molmil
Structure of the human Langerin carbohydrate recognition domain in complex with maltose
分子名称: C-type lectin domain family 4 member K, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Skerra, A, Schiefner, A.
登録日2010-10-12
公開日2010-11-03
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site.
Mol.Immunol., 45, 2008
6SOK
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BU of 6sok by Molmil
Engineered streptavidin variant (VTAR) in complex with the Twin-Strep-tag peptide
分子名称: AMINO GROUP, Streptavidin, Twin-Strep-tag peptide
著者Skerra, A, Eichinger, A.
登録日2019-08-29
公開日2020-09-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6TIP
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BU of 6tip by Molmil
Engineered streptavidin variant (YNAFM) in complex with the Strep-tag II peptide
分子名称: AMINO GROUP, Strep-tag II peptide, Streptavidin
著者Skerra, A, Eichinger, A.
登録日2019-11-22
公開日2020-12-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6SOS
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BU of 6sos by Molmil
Engineered streptavidin variant (ENAGY) in complex with the Twin-Strep-tag peptide
分子名称: Streptavidin, Twin-Strep-tag peptide
著者Skerra, A, Eichinger, A.
登録日2019-08-29
公開日2020-09-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
5NKN
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BU of 5nkn by Molmil
Crystal structure of an Anticalin-colchicine complex
分子名称: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A, Barkovskiy, M.
登録日2017-03-31
公開日2018-04-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications.
Biol. Chem., 400, 2019
5NBW
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BU of 5nbw by Molmil
Crystal structure of the Fab fragment 22F12 in complex with 3-hydroxybenzo[a]pyrene
分子名称: Fab 22F12 (A,B), Fab 22F12 (L,H), benzo[a]pyren-3-ol
著者Skerra, A, Eichinger, A.
登録日2017-03-02
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Tight Molecular Recognition of Benzo[a]pyrene by a High-Affinity Antibody.
Angew. Chem. Int. Ed. Engl., 56, 2017
5MHH
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BU of 5mhh by Molmil
Crystal structure of engineered human lipocalin 2 carrying p-boronophenylalanine at position 36
分子名称: Neutrophil gelatinase-associated lipocalin, SULFATE ION
著者Skerra, A, Eichinger, A.
登録日2016-11-24
公開日2017-10-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rational Design of an Anticalin-Type Sugar-Binding Protein Using a Genetically Encoded Boronate Side Chain.
ACS Synth Biol, 6, 2017
4MVL
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BU of 4mvl by Molmil
Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
分子名称: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2013-09-24
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MVI
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BU of 4mvi by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
分子名称: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2013-09-24
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
1KXO
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BU of 1kxo by Molmil
ENGINEERED LIPOCALIN DIGA16 : APO-FORM
分子名称: DigA16
著者Korndoerfer, I.P, Skerra, A.
登録日2002-02-01
公開日2003-06-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin.
J.Mol.Biol., 330, 2003
8B50
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BU of 8b50 by Molmil
Crystal structure of a Fab fragment in complex with L-hydroxycoumarylalanine
分子名称: (2~{S})-2-azanyl-3-(7-oxidanyl-2-oxidanylidene-chromen-4-yl)propanoic acid, Fab fragment K12F9-22 - heavy chain, Fab fragment K12F9-22 - light chain, ...
著者Meining, W, Eichinger, A, Skerra, A.
登録日2022-09-21
公開日2023-10-04
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Preparation and characterization of monoclonal antibodies against a non natural amino acid carrying the 7-hydroxycoumarin side chain
To be published
6I9Q
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BU of 6i9q by Molmil
Structure of the mouse CD98 heavy chain ectodomain
分子名称: 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, CHLORIDE ION
著者Schiefner, A, Deuschle, F.-C, Skerra, A.
登録日2018-11-24
公開日2019-04-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural differences between the ectodomains of murine and human CD98hc.
Proteins, 87, 2019
1KL3
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BU of 1kl3 by Molmil
an engineered streptavidin with improved affinity for the strep-tag II peptide : SAm1-StrepII
分子名称: strep-tag II peptide, streptavidin
著者Korndoerfer, I.P, Skerra, A.
登録日2001-12-11
公開日2002-04-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Improved affinity of engineered streptavidin for the Strep-tag II peptide is due to a fixed open conformation of the lid-like loop at the binding site.
Protein Sci., 11, 2002
1KFF
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BU of 1kff by Molmil
An engineered streptavidin with improved affinity for the strep-tag II peptide: apo-SAM1
分子名称: streptavidin
著者Korndoerfer, I.P, Skerra, A.
登録日2001-11-20
公開日2002-04-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Improved affinity of engineered streptavidin for the Strep-tag II peptide is due to a fixed open conformation of the lid-like loop at the binding site.
Protein Sci., 11, 2002

 

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