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PDB: 18 件

7QPJ
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Crystal structure of engineered TCR (756) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
分子名称: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ...
著者Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J.
登録日2022-01-04
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
3I5K
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Crystal structure of the NS5B polymerase from Hepatitis C Virus (HCV) strain JFH1
分子名称: PHOSPHATE ION, RNA-directed RNA polymerase
著者Simister, P.C, Schmitt, M, Lohmann, V, Bressanelli, S.
登録日2009-07-05
公開日2009-09-22
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and functional analysis of hepatitis C virus strain JFH1 polymerase
J.Virol., 83, 2009
3U23
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Atomic resolution crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide from human RIN3
分子名称: 1,2-ETHANEDIOL, CD2-associated protein, Ras and Rab interactor 3
著者Simister, P.C, Rouka, E, Janning, M, Muniz, J.R.C, Kirsch, K.H, Knapp, S, von Delft, F, Filippakopoulos, P, Arrowsmith, C.H, Krojer, T, Edwards, A.M, Weigelt, J, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC)
登録日2011-09-30
公開日2011-12-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.11 Å)
主引用文献Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
J.Biol.Chem., 290, 2015
3LTL
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Crystal structure of human BIG1 Sec7 domain
分子名称: ACETIC ACID, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, CALCIUM ION
著者Simister, P.C, Joubert, A, Cherfils, J, Biou, V.
登録日2010-02-16
公開日2011-04-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Sec7 domain structures of human BIG1 and Cytohesin1 Arf nucleotide exchange factors
To be Published
1KN3
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Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)
分子名称: Phosphatidylethanolamine Binding Protein-2
著者Simister, P.C, Banfield, M.J, Brady, R.L.
登録日2001-12-18
公開日2002-06-12
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family.
Acta Crystallogr.,Sect.D, 58, 2002
7PBC
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Crystal structure of engineered TCR (796) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
分子名称: Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ...
著者Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J.
登録日2021-08-02
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
7PDW
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BU of 7pdw by Molmil
Crystal structure of parent TCR (728) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
分子名称: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ...
著者Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J.
登録日2021-08-09
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
7PDX
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Crystal structure of parent MAGE-A10 TCR (728)
分子名称: CHLORIDE ION, PHOSPHATE ION, T-cell receptor alpha chain (TRAV/TRAC), ...
著者Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J.
登録日2021-08-09
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
3RNJ
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Crystal structure of the SH3 domain from IRSp53 (BAIAP2)
分子名称: 1,2-ETHANEDIOL, Brain-specific angiogenesis inhibitor 1-associated protein 2, ISOPROPYL ALCOHOL, ...
著者Simister, P.C, Barilari, M, Muniz, J.R.C, Dente, L, Knapp, S, von Delft, F, Filippakopoulos, P, Vollmar, M, Chaikuad, A, Raynor, J, Tregubova, A, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC)
登録日2011-04-22
公開日2011-05-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of the SH3 domain from IRSp53 (BAIAP2)
To be Published
2QYQ
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Human raf kinase inhibitor protein (rkip) in complex with o-phosphotyrosine
分子名称: O-PHOSPHOTYROSINE, Phosphatidylethanolamine-binding protein 1
著者Simister, P.C, Brady, R.L.
登録日2007-08-15
公開日2008-07-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.948 Å)
主引用文献Phosphotyrosine recognition by the Raf Kinase Inhibitor Protein
Forum Immunopath.Dis.Ther., 2, 2011
2XYM
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HCV-JFH1 NS5B T385A mutant
分子名称: PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE
著者Simister, P.C, Caillet-Saguy, C, Bressanelli, S.
登録日2010-11-18
公開日2011-01-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.774 Å)
主引用文献A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes.
J.Virol., 85, 2011
4WCI
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BU of 4wci by Molmil
Crystal structure of the 1st SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 378-393) from human RIN3
分子名称: CD2-associated protein, Ras and Rab interactor 3, SULFATE ION
著者Rouka, E, Simister, P.C, Janning, M, Kirsch, K.H, Krojer, T, Knapp, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC)
登録日2014-09-04
公開日2015-08-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
J.Biol.Chem., 290, 2015
4X1V
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Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1
分子名称: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, CD2-associated protein
著者Rouka, E, Krojer, T, von Delft, F, Knapp, S, Kirsch, K.H, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Feller, S.M, Simister, P.C.
登録日2014-11-25
公開日2016-02-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1
to be published
2XHU
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HCV-J4 NS5B Polymerase Orthorhombic Crystal Form
分子名称: RNA-directed RNA polymerase, SULFATE ION
著者Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
登録日2010-06-21
公開日2010-08-04
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.287 Å)
主引用文献Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
2XI3
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BU of 2xi3 by Molmil
HCV-H77 NS5B Polymerase Complexed With GTP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA-directed RNA polymerase
著者Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
登録日2010-06-25
公開日2010-08-04
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
2XI2
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BU of 2xi2 by Molmil
HCV-H77 NS5B Apo Polymerase
分子名称: RNA-directed RNA polymerase, SULFATE ION
著者Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
登録日2010-06-25
公開日2010-08-04
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
2XHV
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HCV-J4 NS5B Polymerase Point Mutant Orthorhombic Crystal Form
分子名称: MAGNESIUM ION, RNA-directed RNA polymerase, SULFATE ION
著者Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
登録日2010-06-21
公開日2010-08-04
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
2XHW
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HCV-J4 NS5B Polymerase Trigonal Crystal Form
分子名称: RNA-directed RNA polymerase
著者Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
登録日2010-06-21
公開日2010-08-04
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010

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