3U23

Atomic resolution crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide from human RIN3

Summary for 3U23

Related2FEI 2KRN 4WCI
DescriptorCD2-associated protein, Ras and Rab interactor 3, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsstructural genomics, structural genomics consortium, sgc, beta-barrel, adaptor protein, protein binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton  Q9Y5K6
Cytoplasm  Q8TB24
Total number of polymer chains2
Total molecular weight9309.63
Authors
Primary citation
Rouka, E.,Simister, P.C.,Janning, M.,Kumbrink, J.,Konstantinou, T.,Muniz, J.R.,Joshi, D.,O'Reilly, N.,Volkmer, R.,Ritter, B.,Knapp, S.,von Delft, F.,Kirsch, K.H.,Feller, S.M.
Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
J.Biol.Chem., 290:25275-25292, 2015
PubMed: 26296892 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M115.637207
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.11 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1742001.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution