2XHV
HCV-J4 NS5B Polymerase Point Mutant Orthorhombic Crystal Form
Summary for 2XHV
Entry DOI | 10.2210/pdb2xhv/pdb |
Related | 1NB4 1NB6 1NB7 2F55 2XHU 2XHW |
Descriptor | RNA-directed RNA polymerase, SULFATE ION, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | replication, transcription, transferase |
Biological source | Hepatitis C virus genotype 1b (strain HC-J4) (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): O92972 |
Total number of polymer chains | 2 |
Total formula weight | 131059.92 |
Authors | Harrus, D.,Ahmed-El-Sayed, N.,Simister, P.C.,Miller, S.,Triconnet, M.,Hagedorn, C.H.,Mahias, K.,Rey, F.A.,Astier-Gin, T.,Bressanelli, S. (deposition date: 2010-06-21, release date: 2010-08-04, Last modification date: 2024-03-27) |
Primary citation | Harrus, D.,Ahmed-El-Sayed, N.,Simister, P.C.,Miller, S.,Triconnet, M.,Hagedorn, C.H.,Mahias, K.,Rey, F.A.,Astier-Gin, T.,Bressanelli, S. Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285:32906-, 2010 Cited by PubMed: 20729191DOI: 10.1074/JBC.M110.151316 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report