2XHV
HCV-J4 NS5B Polymerase Point Mutant Orthorhombic Crystal Form
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | RNA-directed RNA polymerase | polymer | 579 | 64641.1 | 2 | UniProt (O92972) Pfam (PF00998) In PDB | Hepatitis C virus genotype 1b (strain HC-J4) (HCV) | NS5B,p68 |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 18 | Chemie (SO4) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | water | water | 18.0 | 687 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: O92972)
PDB | External Database | Details |
---|---|---|
Ala 0 | - | expression tag |
Lys 556 | Ser 2975 | engineered mutation |
Leu 571 | - | expression tag |
Glu 572 | - | expression tag |
His 573 | - | expression tag |
His 574 | - | expression tag |
His 575 | - | expression tag |
His 576 | - | expression tag |
His 577 | - | expression tag |
His 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 129282.2 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 1777.7 | |
All* | Total formula weight | 131059.9 |