3KYK
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![BU of 3kyk by Molmil](/molmil-images/mine/3kyk) | Crystal structure of li33 Igg1 Fab | 分子名称: | Heavy Chain Li33 IgG1, Light Chain Li33 IgG1, SULFATE ION | 著者 | Silvian, L.F, Pepinsky, R.B, Walus, L. | 登録日 | 2009-12-06 | 公開日 | 2010-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis. Protein Sci., 19, 2010
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1QU2
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![BU of 1qu2 by Molmil](/molmil-images/mine/1qu2) | INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN | 分子名称: | ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, MAGNESIUM ION, ... | 著者 | Silvian, L.F, Wang, J, Steitz, T.A. | 登録日 | 1999-07-06 | 公開日 | 1999-08-31 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. Science, 285, 1999
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1QU3
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![BU of 1qu3 by Molmil](/molmil-images/mine/1qu3) | INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN | 分子名称: | ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, MUPIROCIN, ... | 著者 | Silvian, L.F, Wang, J, Steitz, T.A. | 登録日 | 1999-07-06 | 公開日 | 1999-08-31 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. Science, 285, 1999
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1FFY
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![BU of 1ffy by Molmil](/molmil-images/mine/1ffy) | INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN | 分子名称: | ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, MAGNESIUM ION, ... | 著者 | Silvian, L.F, Wang, J, Steitz, T.A. | 登録日 | 2000-07-26 | 公開日 | 2000-08-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. Science, 285, 1999
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5J5T
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![BU of 5j5t by Molmil](/molmil-images/mine/5j5t) | GLK co-crystal structure with aminopyrrolopyrimidine inhibitor | 分子名称: | 5-[2-(piperidin-4-yl)-1,3-thiazol-5-yl]-3-[(pyridin-4-yl)methoxy]pyridin-2-amine, Mitogen-activated protein kinase kinase kinase kinase 3 | 著者 | Silvian, L.F, Marcotte, D. | 登録日 | 2016-04-03 | 公開日 | 2016-10-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension. Protein Sci., 26, 2017
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3LKJ
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![BU of 3lkj by Molmil](/molmil-images/mine/3lkj) | Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism | 分子名称: | (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand | 著者 | Silvian, L.F, Whitty, A. | 登録日 | 2010-01-27 | 公開日 | 2011-02-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism. Acs Chem.Biol., 6, 2011
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3KJ4
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![BU of 3kj4 by Molmil](/molmil-images/mine/3kj4) | Structure of rat Nogo receptor bound to 1D9 antagonist antibody | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab fragment 1D9 heavy chain, ... | 著者 | Silvian, L.F. | 登録日 | 2009-11-02 | 公開日 | 2010-09-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering. Biotechnol Appl Biochem, 57, 2010
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3KYM
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3E2M
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![BU of 3e2m by Molmil](/molmil-images/mine/3e2m) | LFA-1 I domain bound to inhibitors | 分子名称: | Integrin alpha-L, cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)phenoxy]methyl}cyclohexanecarboxylic acid | 著者 | Silvian, L.F. | 登録日 | 2008-08-05 | 公開日 | 2008-08-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3BQN
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![BU of 3bqn by Molmil](/molmil-images/mine/3bqn) | LFA-1 I domain bound to inhibitors | 分子名称: | 4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfanyl}-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl}morpholine, Integrin alpha-L | 著者 | Silvian, L.F. | 登録日 | 2007-12-20 | 公開日 | 2008-08-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3BRV
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![BU of 3brv by Molmil](/molmil-images/mine/3brv) | NEMO/IKKb association domain structure | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit beta, NF-kappa-B essential modulator | 著者 | Silvian, L.F. | 登録日 | 2007-12-21 | 公開日 | 2008-04-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site. Structure, 16, 2008
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3BQM
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![BU of 3bqm by Molmil](/molmil-images/mine/3bqm) | LFA-1 I domain bound to inhibitors | 分子名称: | 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline, Integrin alpha-L | 著者 | Silvian, L.F. | 登録日 | 2007-12-20 | 公開日 | 2008-08-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3BRT
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![BU of 3brt by Molmil](/molmil-images/mine/3brt) | NEMO/IKK association domain structure | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit beta,Inhibitor of nuclear factor kappa-B kinase subunit alpha, NF-kappa-B essential modulator | 著者 | Silvian, L.F. | 登録日 | 2007-12-21 | 公開日 | 2008-04-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site. Structure, 16, 2008
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1K1S
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![BU of 1k1s by Molmil](/molmil-images/mine/1k1s) | Crystal Structure of DinB from Sulfolobus solfataricus | 分子名称: | DBH protein | 著者 | Silvian, L.F, Toth, E.A, Pham, P, Goodman, M.F, Ellenberger, T. | 登録日 | 2001-09-25 | 公開日 | 2001-10-31 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus. Nat.Struct.Biol., 8, 2001
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1K1Q
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![BU of 1k1q by Molmil](/molmil-images/mine/1k1q) | Crystal Structure of a DinB Family Error Prone DNA Polymerase from Sulfolobus solfataricus | 分子名称: | DBH protein | 著者 | Silvian, L.F, Toth, E.A, Pham, P, Goodman, M.F, Ellenberger, T. | 登録日 | 2001-09-25 | 公開日 | 2001-10-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus. Nat.Struct.Biol., 8, 2001
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4X7Q
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![BU of 4x7q by Molmil](/molmil-images/mine/4x7q) | PIM2 kinase in complex with Compound 1s | 分子名称: | 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, PHOSPHATE ION, Serine/threonine-protein kinase pim-2 | 著者 | Marcotte, D.J, Silvian, L.F. | 登録日 | 2014-12-09 | 公開日 | 2015-02-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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4XHK
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![BU of 4xhk by Molmil](/molmil-images/mine/4xhk) | PIM1 kinase in complex with Compound 1s | 分子名称: | 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, Serine/threonine-protein kinase pim-1 | 著者 | Marcotte, D.J, Silvian, L.F. | 登録日 | 2015-01-05 | 公開日 | 2015-02-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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3K54
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![BU of 3k54 by Molmil](/molmil-images/mine/3k54) | Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases. | 分子名称: | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Tyrosine-protein kinase BTK | 著者 | Marcotte, D.J, Liu, Y.-T, Arduini, R.M, Hession, C.A, Miatkowski, K, Wildes, C.P, Cullen, P.F, Hopkins, B.T, Mertsching, E, Jenkins, T.J, Romanowski, M.J, Baker, D.P, Silvian, L.F. | 登録日 | 2009-10-06 | 公開日 | 2010-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. Protein Sci., 19, 2010
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3GEN
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![BU of 3gen by Molmil](/molmil-images/mine/3gen) | The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound | 分子名称: | 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane, Tyrosine-protein kinase BTK | 著者 | Marcotte, D.J, Liu, Y.T, Arduini, R.M, Hession, C.A, Miatkowski, K, Wildes, C.P, Cullen, P.F, Hopkins, B, Mertsching, E, Jenkins, T.J, Romanowski, M.J, Baker, D.P, Silvian, L.F. | 登録日 | 2009-02-25 | 公開日 | 2010-01-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. Protein Sci., 19, 2010
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1QTQ
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![BU of 1qtq by Molmil](/molmil-images/mine/1qtq) | GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNA AND AN AMINO ACID ANALOG | 分子名称: | 5'-O-[N-(L-GLUTAMINYL)-SULFAMOYL]ADENOSINE, PROTEIN (GLUTAMINYL-TRNA SYNTHETASE), RNA (TRNA GLN II ), ... | 著者 | Rath, V.L, Silvian, L.F, Beijer, B, Sproat, B.S, Steitz, T.A. | 登録日 | 1998-01-28 | 公開日 | 1998-05-27 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | How glutaminyl-tRNA synthetase selects glutamine. Structure, 6, 1998
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3M1N
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![BU of 3m1n by Molmil](/molmil-images/mine/3m1n) | Crystal structure of Human Sonic Hedgehog N-terminal domain | 分子名称: | SULFATE ION, Sonic hedgehog protein, ZINC ION | 著者 | Boriack-Sjodin, P.A, Pepinsky, R.B, Garber, E.A, Silvian, L.F. | 登録日 | 2010-03-05 | 公開日 | 2010-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mapping sonic hedgehog-receptor interactions by steric interference. J.Biol.Chem., 275, 2000
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