3K54

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases.

Summary for 3K54

• Entry DOI: 10.2210/pdb3k54/pdb
• Descriptor: Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total)
• Functional Keywords: bruton's tyrosine kinase, btk, dasatinib, atp-binding, disease mutation, kinase, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q06187
• Total number of polymer chains: 1
• Total formula weight: 33134.42

Authors

Marcotte, D.J.,Liu, Y.-T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hopkins, B.T.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F. (deposition date: 2009-10-06, release date: 2010-01-19, Last modification date: 2023-09-06)

• Primary citation: Marcotte, D.J.,Liu, Y.T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hong, V.,Hopkins, B.T.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F.; Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.; Protein Sci., 19:429-439, 2010; PubMed: 20052711; DOI: 10.1002/pro.321

Experimental method

X-RAY DIFFRACTION (1.94 Å)