3GEN

The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound

Summary for 3GEN

• Entry DOI: 10.2210/pdb3gen/pdb
• Descriptor: Tyrosine-protein kinase BTK, 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane (3 entities in total)
• Functional Keywords: bruton's tyrosine kinase, 4-amino-5-(4-phenoxyphenyl)-5h-pyrrolo[3, 2-d]pyrimidin-7-yl-cyclopentane, tec-family, complex, acetylation, atp-binding, cytoplasm, disease mutation, kinase, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, polymorphism, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, zinc, zinc-finger
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q06187
• Total number of polymer chains: 1
• Total formula weight: 33050.92

Authors

Marcotte, D.J.,Liu, Y.T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hopkins, B.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F. (deposition date: 2009-02-25, release date: 2010-01-19, Last modification date: 2024-03-13)

• Primary citation: Marcotte, D.J.,Liu, Y.T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hong, V.,Hopkins, B.T.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F.; Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.; Protein Sci., 19:429-439, 2010; PubMed: 20052711; DOI: 10.1002/pro.321

Experimental method

X-RAY DIFFRACTION (1.6 Å)