3GEN
The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 283 | 32680.5 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (human) | Bruton tyrosine kinase, Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK |
| 2 | B (A) | 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | non-polymer | 370.4 | 1 | Chemie (B43) | |||
| 3 | C (A) | water | water | 18.0 | 495 | Chemie (HOH) |
Sequence modifications
A: 382 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 377 | - | expression tag |
| Pro 378 | - | expression tag |
| Leu 379 | - | expression tag |
| Gly 380 | - | expression tag |
| Ser 381 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32680.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 370.4 | |
| All* | Total formula weight | 33050.9 |
