5AWD
 
 | | Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (IMDQ) | | Descriptor: | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Tanji, H, Ohto, U, Shimizu, T. | | Deposit date: | 2015-07-03 | | Release date: | 2015-09-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.
J.Med.Chem., 58, 2015
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5AZ5
 | | Crystal structure of human TLR8 in complex with MB-343 | | Descriptor: | 1-pentyl-4-phenyl-imidazol-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Tanji, H, Ohto, U, Shimizu, T. | | Deposit date: | 2015-09-27 | | Release date: | 2016-10-05 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of human TLR8 in complex with MB-343
To Be Published
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7VGR
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7VGS
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6KYA
 | | Crystal structure of human TLR8 in complex TH1027 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ... | | Authors: | Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T. | | Deposit date: | 2019-09-17 | | Release date: | 2020-05-27 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
J.Med.Chem., 63, 2020
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7VAF
 | | Cryo-EM structure of Rat NTCP complexed with YN69202Fab | | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter | | Authors: | Asami, J, Shimizu, T, Ohto, U. | | Deposit date: | 2021-08-29 | | Release date: | 2022-05-25 | | Last modified: | 2022-07-13 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
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7VAG
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7VAE
 | | Cryo-EM structure of bovine NTCP complexed with YN69202Fab | | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ... | | Authors: | Asami, J, Shimizu, T, Ohto, U. | | Deposit date: | 2021-08-29 | | Release date: | 2022-05-25 | | Last modified: | 2022-07-13 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
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7VAD
 | | Cryo-EM structure of human NTCP complexed with YN69202Fab | | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter | | Authors: | Asami, J, Shimizu, T, Ohto, U. | | Deposit date: | 2021-08-29 | | Release date: | 2022-05-25 | | Last modified: | 2022-07-13 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
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7WSI
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1WLF
 | | Structure of the N-terminal domain of PEX1 AAA-ATPase: Characterization of a putative adaptor-binding domain | | Descriptor: | Peroxisome biogenesis factor 1, SULFATE ION | | Authors: | Shiozawa, K, Maita, N, Tomii, K, Seto, A, Goda, N, Tochio, H, Akiyama, Y, Shimizu, T, Shirakawa, M, Hiroaki, H. | | Deposit date: | 2004-06-25 | | Release date: | 2004-09-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure of the N-terminal Domain of PEX1 AAA-ATPase: CHARACTERIZATION OF A PUTATIVE ADAPTOR-BINDING DOMAIN
J.Biol.Chem., 279, 2004
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1WDA
 | | Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with benzoyl-L-arginine amide | | Descriptor: | CALCIUM ION, N-[(E)-2-AMINO-1-(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)-2-HYDROXYVINYL]BENZAMIDE, Protein-arginine deiminase type IV, ... | | Authors: | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | | Deposit date: | 2004-05-12 | | Release date: | 2004-07-13 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for Ca(2+)-induced activation of human PAD4
Nat.Struct.Mol.Biol., 11, 2004
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1WD9
 | | Calcium bound form of human peptidylarginine deiminase type4 (PAD4) | | Descriptor: | CALCIUM ION, Protein-arginine deiminase type IV, SULFATE ION | | Authors: | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | | Deposit date: | 2004-05-12 | | Release date: | 2004-07-13 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for Ca(2+)-induced activation of human PAD4
Nat.Struct.Mol.Biol., 11, 2004
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1WD8
 | | Calcium free form of human peptidylarginine deiminase type4 (PAD4) | | Descriptor: | Protein-arginine deiminase type IV | | Authors: | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | | Deposit date: | 2004-05-12 | | Release date: | 2004-07-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for Ca(2+)-induced activation of human PAD4
Nat.Struct.Mol.Biol., 11, 2004
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1UHN
 | | The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana | | Descriptor: | CALCIUM ION, calcineurin B-like protein 2 | | Authors: | Nagae, M, Nozawa, A, Koizumi, N, Sano, H, Hashimoto, H, Sato, M, Shimizu, T. | | Deposit date: | 2003-07-07 | | Release date: | 2003-11-04 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Crystal Structure of the Novel Calcium-binding Protein AtCBL2 from Arabidopsis thaliana
J.Biol.Chem., 278, 2003
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1V9Y
 | | Crystal Structure of the heme PAS sensor domain of Ec DOS (ferric form) | | Descriptor: | Heme pas sensor protein, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kurokawa, H, Lee, D.S, Watanabe, M, Sagami, I, Mikami, B, Raman, C.S, Shimizu, T. | | Deposit date: | 2004-02-04 | | Release date: | 2004-05-25 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor.
J.Biol.Chem., 279, 2004
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1V9Z
 | | Crystal Structure of the heme PAS sensor domain of Ec DOS (Ferrous Form) | | Descriptor: | Heme pas sensor protein, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kurokawa, H, Lee, D.S, Watanabe, M, Sagami, I, Mikami, B, Raman, C.S, Shimizu, T. | | Deposit date: | 2004-02-04 | | Release date: | 2004-05-25 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor.
J.Biol.Chem., 279, 2004
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1VB6
 | | Crystal Structure of the heme PAS sensor domain of Ec DOS (oxygen-bound form) | | Descriptor: | Heme pas sensor protein, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kurokawa, H, Watanabe, M, Sagami, I, Mikami, B, Shimizu, T. | | Deposit date: | 2004-02-24 | | Release date: | 2005-04-19 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Structure of oxygen-bound form of a Heme PAS domain of Ec DOS
To be Published
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3VKX
 | | Structure of PCNA | | Descriptor: | 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ... | | Authors: | Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N. | | Deposit date: | 2011-11-26 | | Release date: | 2012-03-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
J.Biol.Chem., 287, 2012
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5XGC
 | | Crystal structure of SmgGDS-558 | | Descriptor: | Rap1 GTPase-GDP dissociation stimulator 1 | | Authors: | Shimizu, H, Toma-Fukai, S, Shimizu, T. | | Deposit date: | 2017-04-13 | | Release date: | 2017-06-28 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding
J. Biol. Chem., 292, 2017
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7VTQ
 | | Cryo-EM structure of mouse NLRP3 (full-length) dodecamer | | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | | Authors: | Ohto, U, Shimizu, T. | | Deposit date: | 2021-10-30 | | Release date: | 2022-03-09 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VTP
 | | Cryo-EM structure of PYD-deleted human NLRP3 hexamer | | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | | Authors: | Ohto, U, Shimizu, T. | | Deposit date: | 2021-10-30 | | Release date: | 2022-03-09 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7WBT
 | | Crystal structure of bovine NLRP9 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9 | | Authors: | Kamitsukasa, Y, Shimizu, T, Ohto, U. | | Deposit date: | 2021-12-17 | | Release date: | 2022-04-06 | | Last modified: | 2022-04-27 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Febs Lett., 596, 2022
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7WBU
 | | Cryo-EM structure of bovine NLRP9 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9 | | Authors: | Kamitsukasa, Y, Shimizu, T, Ohto, U. | | Deposit date: | 2021-12-17 | | Release date: | 2022-04-06 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Febs Lett., 596, 2022
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5ZHX
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