7VTQ
Cryo-EM structure of mouse NLRP3 (full-length) dodecamer
Summary for 7VTQ
Entry DOI | 10.2210/pdb7vtq/pdb |
EMDB information | 32120 |
Descriptor | NACHT, LRR and PYD domains-containing protein 3, ADENOSINE-5'-DIPHOSPHATE, 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea (3 entities in total) |
Functional Keywords | nlr, nod-like receptor, nlrp3, inflammasome, immune system |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 12 |
Total formula weight | 1466947.70 |
Authors | Ohto, U.,Shimizu, T. (deposition date: 2021-10-30, release date: 2022-03-09, Last modification date: 2022-03-23) |
Primary citation | Ohto, U.,Kamitsukasa, Y.,Ishida, H.,Zhang, Z.,Murakami, K.,Hirama, C.,Maekawa, S.,Shimizu, T. Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation. Proc.Natl.Acad.Sci.USA, 119:e2121353119-e2121353119, 2022 Cited by PubMed: 35254907DOI: 10.1073/pnas.2121353119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.55 Å) |
Structure validation
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