7VTQ

Cryo-EM structure of mouse NLRP3 (full-length) dodecamer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	NACHT, LRR and PYD domains-containing protein 3	polymer	1057	121416.0	12	UniProt (Q8R4B8) Pfam (PF02758) Pfam (PF14484) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) Pfam (PF13516) In PDB	Mus musculus (Mouse)
2	H, I, J, K, L...	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	12	Chemie (ADP)
3	H, I, J, K, L...	1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea	non-polymer		402.5	12	Chemie (7YN)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 1 - 1033 (UniProt: Q8R4B8)

PDB	External Database	Details
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
Asp -17	-	expression tag
Tyr -16	-	expression tag
Lys -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Leu -9	-	expression tag
Glu -8	-	expression tag
Val -7	-	expression tag
Leu -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	1456991.7
Non-Polymers*	Number of molecules	24
	Total formula weight	9956.0
All*	Total formula weight	1466947.7

*Water molecules are not included.