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7VTQ

Cryo-EM structure of mouse NLRP3 (full-length) dodecamer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0002221biological_processpattern recognition receptor signaling pathway
A0002523biological_processleukocyte migration involved in inflammatory response
A0002526biological_processacute inflammatory response
A0002674biological_processnegative regulation of acute inflammatory response
A0002720biological_processpositive regulation of cytokine production involved in immune response
A0002830biological_processpositive regulation of type 2 immune response
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005815cellular_componentmicrotubule organizing center
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006954biological_processinflammatory response
A0007231biological_processosmosensory signaling pathway
A0009595biological_processdetection of biotic stimulus
A0014070biological_processresponse to organic cyclic compound
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0031021cellular_componentinterphase microtubule organizing center
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032736biological_processpositive regulation of interleukin-13 production
A0032753biological_processpositive regulation of interleukin-4 production
A0032754biological_processpositive regulation of interleukin-5 production
A0035591molecular_functionsignaling adaptor activity
A0043531molecular_functionADP binding
A0043565molecular_functionsequence-specific DNA binding
A0044546biological_processNLRP3 inflammasome complex assembly
A0045087biological_processinnate immune response
A0045471biological_processresponse to ethanol
A0045630biological_processpositive regulation of T-helper 2 cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050727biological_processregulation of inflammatory response
A0050729biological_processpositive regulation of inflammatory response
A0050830biological_processdefense response to Gram-positive bacterium
A0051260biological_processprotein homooligomerization
A0051607biological_processdefense response to virus
A0061702cellular_componentcanonical inflammasome complex
A0070269biological_processpyroptotic inflammatory response
A0070273molecular_functionphosphatidylinositol-4-phosphate binding
A0071222biological_processcellular response to lipopolysaccharide
A0071224biological_processcellular response to peptidoglycan
A0072559cellular_componentNLRP3 inflammasome complex
A0140297molecular_functionDNA-binding transcription factor binding
A0140299molecular_functionsmall molecule sensor activity
A1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
A1901981molecular_functionphosphatidylinositol phosphate binding
A2000321biological_processpositive regulation of T-helper 17 cell differentiation
A2000553biological_processpositive regulation of T-helper 2 cell cytokine production
B0000139cellular_componentGolgi membrane
B0002221biological_processpattern recognition receptor signaling pathway
B0002523biological_processleukocyte migration involved in inflammatory response
B0002526biological_processacute inflammatory response
B0002674biological_processnegative regulation of acute inflammatory response
B0002720biological_processpositive regulation of cytokine production involved in immune response
B0002830biological_processpositive regulation of type 2 immune response
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005815cellular_componentmicrotubule organizing center
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006954biological_processinflammatory response
B0007231biological_processosmosensory signaling pathway
B0009595biological_processdetection of biotic stimulus
B0014070biological_processresponse to organic cyclic compound
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0031021cellular_componentinterphase microtubule organizing center
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032736biological_processpositive regulation of interleukin-13 production
B0032753biological_processpositive regulation of interleukin-4 production
B0032754biological_processpositive regulation of interleukin-5 production
B0035591molecular_functionsignaling adaptor activity
B0043531molecular_functionADP binding
B0043565molecular_functionsequence-specific DNA binding
B0044546biological_processNLRP3 inflammasome complex assembly
B0045087biological_processinnate immune response
B0045471biological_processresponse to ethanol
B0045630biological_processpositive regulation of T-helper 2 cell differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050727biological_processregulation of inflammatory response
B0050729biological_processpositive regulation of inflammatory response
B0050830biological_processdefense response to Gram-positive bacterium
B0051260biological_processprotein homooligomerization
B0051607biological_processdefense response to virus
B0061702cellular_componentcanonical inflammasome complex
B0070269biological_processpyroptotic inflammatory response
B0070273molecular_functionphosphatidylinositol-4-phosphate binding
B0071222biological_processcellular response to lipopolysaccharide
B0071224biological_processcellular response to peptidoglycan
B0072559cellular_componentNLRP3 inflammasome complex
B0140297molecular_functionDNA-binding transcription factor binding
B0140299molecular_functionsmall molecule sensor activity
B1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
B1901981molecular_functionphosphatidylinositol phosphate binding
B2000321biological_processpositive regulation of T-helper 17 cell differentiation
B2000553biological_processpositive regulation of T-helper 2 cell cytokine production
C0000139cellular_componentGolgi membrane
C0002221biological_processpattern recognition receptor signaling pathway
C0002523biological_processleukocyte migration involved in inflammatory response
C0002526biological_processacute inflammatory response
C0002674biological_processnegative regulation of acute inflammatory response
C0002720biological_processpositive regulation of cytokine production involved in immune response
C0002830biological_processpositive regulation of type 2 immune response
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005815cellular_componentmicrotubule organizing center
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006954biological_processinflammatory response
C0007231biological_processosmosensory signaling pathway
C0009595biological_processdetection of biotic stimulus
C0014070biological_processresponse to organic cyclic compound
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0031021cellular_componentinterphase microtubule organizing center
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032736biological_processpositive regulation of interleukin-13 production
C0032753biological_processpositive regulation of interleukin-4 production
C0032754biological_processpositive regulation of interleukin-5 production
C0035591molecular_functionsignaling adaptor activity
C0043531molecular_functionADP binding
C0043565molecular_functionsequence-specific DNA binding
C0044546biological_processNLRP3 inflammasome complex assembly
C0045087biological_processinnate immune response
C0045471biological_processresponse to ethanol
C0045630biological_processpositive regulation of T-helper 2 cell differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0050727biological_processregulation of inflammatory response
C0050729biological_processpositive regulation of inflammatory response
C0050830biological_processdefense response to Gram-positive bacterium
C0051260biological_processprotein homooligomerization
C0051607biological_processdefense response to virus
C0061702cellular_componentcanonical inflammasome complex
C0070269biological_processpyroptotic inflammatory response
C0070273molecular_functionphosphatidylinositol-4-phosphate binding
C0071222biological_processcellular response to lipopolysaccharide
C0071224biological_processcellular response to peptidoglycan
C0072559cellular_componentNLRP3 inflammasome complex
C0140297molecular_functionDNA-binding transcription factor binding
C0140299molecular_functionsmall molecule sensor activity
C1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
C1901981molecular_functionphosphatidylinositol phosphate binding
C2000321biological_processpositive regulation of T-helper 17 cell differentiation
C2000553biological_processpositive regulation of T-helper 2 cell cytokine production
D0000139cellular_componentGolgi membrane
D0002221biological_processpattern recognition receptor signaling pathway
D0002523biological_processleukocyte migration involved in inflammatory response
D0002526biological_processacute inflammatory response
D0002674biological_processnegative regulation of acute inflammatory response
D0002720biological_processpositive regulation of cytokine production involved in immune response
D0002830biological_processpositive regulation of type 2 immune response
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005815cellular_componentmicrotubule organizing center
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0006954biological_processinflammatory response
D0007231biological_processosmosensory signaling pathway
D0009595biological_processdetection of biotic stimulus
D0014070biological_processresponse to organic cyclic compound
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0031021cellular_componentinterphase microtubule organizing center
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032736biological_processpositive regulation of interleukin-13 production
D0032753biological_processpositive regulation of interleukin-4 production
D0032754biological_processpositive regulation of interleukin-5 production
D0035591molecular_functionsignaling adaptor activity
D0043531molecular_functionADP binding
D0043565molecular_functionsequence-specific DNA binding
D0044546biological_processNLRP3 inflammasome complex assembly
D0045087biological_processinnate immune response
D0045471biological_processresponse to ethanol
D0045630biological_processpositive regulation of T-helper 2 cell differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0050727biological_processregulation of inflammatory response
D0050729biological_processpositive regulation of inflammatory response
D0050830biological_processdefense response to Gram-positive bacterium
D0051260biological_processprotein homooligomerization
D0051607biological_processdefense response to virus
D0061702cellular_componentcanonical inflammasome complex
D0070269biological_processpyroptotic inflammatory response
D0070273molecular_functionphosphatidylinositol-4-phosphate binding
D0071222biological_processcellular response to lipopolysaccharide
D0071224biological_processcellular response to peptidoglycan
D0072559cellular_componentNLRP3 inflammasome complex
D0140297molecular_functionDNA-binding transcription factor binding
D0140299molecular_functionsmall molecule sensor activity
D1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
D1901981molecular_functionphosphatidylinositol phosphate binding
D2000321biological_processpositive regulation of T-helper 17 cell differentiation
D2000553biological_processpositive regulation of T-helper 2 cell cytokine production
E0000139cellular_componentGolgi membrane
E0002221biological_processpattern recognition receptor signaling pathway
E0002523biological_processleukocyte migration involved in inflammatory response
E0002526biological_processacute inflammatory response
E0002674biological_processnegative regulation of acute inflammatory response
E0002720biological_processpositive regulation of cytokine production involved in immune response
E0002830biological_processpositive regulation of type 2 immune response
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005783cellular_componentendoplasmic reticulum
E0005794cellular_componentGolgi apparatus
E0005815cellular_componentmicrotubule organizing center
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0006954biological_processinflammatory response
E0007231biological_processosmosensory signaling pathway
E0009595biological_processdetection of biotic stimulus
E0014070biological_processresponse to organic cyclic compound
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0031021cellular_componentinterphase microtubule organizing center
E0032731biological_processpositive regulation of interleukin-1 beta production
E0032736biological_processpositive regulation of interleukin-13 production
E0032753biological_processpositive regulation of interleukin-4 production
E0032754biological_processpositive regulation of interleukin-5 production
E0035591molecular_functionsignaling adaptor activity
E0043531molecular_functionADP binding
E0043565molecular_functionsequence-specific DNA binding
E0044546biological_processNLRP3 inflammasome complex assembly
E0045087biological_processinnate immune response
E0045471biological_processresponse to ethanol
E0045630biological_processpositive regulation of T-helper 2 cell differentiation
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0050727biological_processregulation of inflammatory response
E0050729biological_processpositive regulation of inflammatory response
E0050830biological_processdefense response to Gram-positive bacterium
E0051260biological_processprotein homooligomerization
E0051607biological_processdefense response to virus
E0061702cellular_componentcanonical inflammasome complex
E0070269biological_processpyroptotic inflammatory response
E0070273molecular_functionphosphatidylinositol-4-phosphate binding
E0071222biological_processcellular response to lipopolysaccharide
E0071224biological_processcellular response to peptidoglycan
E0072559cellular_componentNLRP3 inflammasome complex
E0140297molecular_functionDNA-binding transcription factor binding
E0140299molecular_functionsmall molecule sensor activity
E1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
E1901981molecular_functionphosphatidylinositol phosphate binding
E2000321biological_processpositive regulation of T-helper 17 cell differentiation
E2000553biological_processpositive regulation of T-helper 2 cell cytokine production
F0000139cellular_componentGolgi membrane
F0002221biological_processpattern recognition receptor signaling pathway
F0002523biological_processleukocyte migration involved in inflammatory response
F0002526biological_processacute inflammatory response
F0002674biological_processnegative regulation of acute inflammatory response
F0002720biological_processpositive regulation of cytokine production involved in immune response
F0002830biological_processpositive regulation of type 2 immune response
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005783cellular_componentendoplasmic reticulum
F0005794cellular_componentGolgi apparatus
F0005815cellular_componentmicrotubule organizing center
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0006954biological_processinflammatory response
F0007231biological_processosmosensory signaling pathway
F0009595biological_processdetection of biotic stimulus
F0014070biological_processresponse to organic cyclic compound
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0031021cellular_componentinterphase microtubule organizing center
F0032731biological_processpositive regulation of interleukin-1 beta production
F0032736biological_processpositive regulation of interleukin-13 production
F0032753biological_processpositive regulation of interleukin-4 production
F0032754biological_processpositive regulation of interleukin-5 production
F0035591molecular_functionsignaling adaptor activity
F0043531molecular_functionADP binding
F0043565molecular_functionsequence-specific DNA binding
F0044546biological_processNLRP3 inflammasome complex assembly
F0045087biological_processinnate immune response
F0045471biological_processresponse to ethanol
F0045630biological_processpositive regulation of T-helper 2 cell differentiation
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0050727biological_processregulation of inflammatory response
F0050729biological_processpositive regulation of inflammatory response
F0050830biological_processdefense response to Gram-positive bacterium
F0051260biological_processprotein homooligomerization
F0051607biological_processdefense response to virus
F0061702cellular_componentcanonical inflammasome complex
F0070269biological_processpyroptotic inflammatory response
F0070273molecular_functionphosphatidylinositol-4-phosphate binding
F0071222biological_processcellular response to lipopolysaccharide
F0071224biological_processcellular response to peptidoglycan
F0072559cellular_componentNLRP3 inflammasome complex
F0140297molecular_functionDNA-binding transcription factor binding
F0140299molecular_functionsmall molecule sensor activity
F1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
F1901981molecular_functionphosphatidylinositol phosphate binding
F2000321biological_processpositive regulation of T-helper 17 cell differentiation
F2000553biological_processpositive regulation of T-helper 2 cell cytokine production
G0000139cellular_componentGolgi membrane
G0002221biological_processpattern recognition receptor signaling pathway
G0002523biological_processleukocyte migration involved in inflammatory response
G0002526biological_processacute inflammatory response
G0002674biological_processnegative regulation of acute inflammatory response
G0002720biological_processpositive regulation of cytokine production involved in immune response
G0002830biological_processpositive regulation of type 2 immune response
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005783cellular_componentendoplasmic reticulum
G0005794cellular_componentGolgi apparatus
G0005815cellular_componentmicrotubule organizing center
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0006954biological_processinflammatory response
G0007231biological_processosmosensory signaling pathway
G0009595biological_processdetection of biotic stimulus
G0014070biological_processresponse to organic cyclic compound
G0016020cellular_componentmembrane
G0016787molecular_functionhydrolase activity
G0016887molecular_functionATP hydrolysis activity
G0031021cellular_componentinterphase microtubule organizing center
G0032731biological_processpositive regulation of interleukin-1 beta production
G0032736biological_processpositive regulation of interleukin-13 production
G0032753biological_processpositive regulation of interleukin-4 production
G0032754biological_processpositive regulation of interleukin-5 production
G0035591molecular_functionsignaling adaptor activity
G0043531molecular_functionADP binding
G0043565molecular_functionsequence-specific DNA binding
G0044546biological_processNLRP3 inflammasome complex assembly
G0045087biological_processinnate immune response
G0045471biological_processresponse to ethanol
G0045630biological_processpositive regulation of T-helper 2 cell differentiation
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0050727biological_processregulation of inflammatory response
G0050729biological_processpositive regulation of inflammatory response
G0050830biological_processdefense response to Gram-positive bacterium
G0051260biological_processprotein homooligomerization
G0051607biological_processdefense response to virus
G0061702cellular_componentcanonical inflammasome complex
G0070269biological_processpyroptotic inflammatory response
G0070273molecular_functionphosphatidylinositol-4-phosphate binding
G0071222biological_processcellular response to lipopolysaccharide
G0071224biological_processcellular response to peptidoglycan
G0072559cellular_componentNLRP3 inflammasome complex
G0140297molecular_functionDNA-binding transcription factor binding
G0140299molecular_functionsmall molecule sensor activity
G1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
G1901981molecular_functionphosphatidylinositol phosphate binding
G2000321biological_processpositive regulation of T-helper 17 cell differentiation
G2000553biological_processpositive regulation of T-helper 2 cell cytokine production
H0000139cellular_componentGolgi membrane
H0002221biological_processpattern recognition receptor signaling pathway
H0002523biological_processleukocyte migration involved in inflammatory response
H0002526biological_processacute inflammatory response
H0002674biological_processnegative regulation of acute inflammatory response
H0002720biological_processpositive regulation of cytokine production involved in immune response
H0002830biological_processpositive regulation of type 2 immune response
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005783cellular_componentendoplasmic reticulum
H0005794cellular_componentGolgi apparatus
H0005815cellular_componentmicrotubule organizing center
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0006954biological_processinflammatory response
H0007231biological_processosmosensory signaling pathway
H0009595biological_processdetection of biotic stimulus
H0014070biological_processresponse to organic cyclic compound
H0016020cellular_componentmembrane
H0016787molecular_functionhydrolase activity
H0016887molecular_functionATP hydrolysis activity
H0031021cellular_componentinterphase microtubule organizing center
H0032731biological_processpositive regulation of interleukin-1 beta production
H0032736biological_processpositive regulation of interleukin-13 production
H0032753biological_processpositive regulation of interleukin-4 production
H0032754biological_processpositive regulation of interleukin-5 production
H0035591molecular_functionsignaling adaptor activity
H0043531molecular_functionADP binding
H0043565molecular_functionsequence-specific DNA binding
H0044546biological_processNLRP3 inflammasome complex assembly
H0045087biological_processinnate immune response
H0045471biological_processresponse to ethanol
H0045630biological_processpositive regulation of T-helper 2 cell differentiation
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0050727biological_processregulation of inflammatory response
H0050729biological_processpositive regulation of inflammatory response
H0050830biological_processdefense response to Gram-positive bacterium
H0051260biological_processprotein homooligomerization
H0051607biological_processdefense response to virus
H0061702cellular_componentcanonical inflammasome complex
H0070269biological_processpyroptotic inflammatory response
H0070273molecular_functionphosphatidylinositol-4-phosphate binding
H0071222biological_processcellular response to lipopolysaccharide
H0071224biological_processcellular response to peptidoglycan
H0072559cellular_componentNLRP3 inflammasome complex
H0140297molecular_functionDNA-binding transcription factor binding
H0140299molecular_functionsmall molecule sensor activity
H1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
H1901981molecular_functionphosphatidylinositol phosphate binding
H2000321biological_processpositive regulation of T-helper 17 cell differentiation
H2000553biological_processpositive regulation of T-helper 2 cell cytokine production
I0000139cellular_componentGolgi membrane
I0002221biological_processpattern recognition receptor signaling pathway
I0002523biological_processleukocyte migration involved in inflammatory response
I0002526biological_processacute inflammatory response
I0002674biological_processnegative regulation of acute inflammatory response
I0002720biological_processpositive regulation of cytokine production involved in immune response
I0002830biological_processpositive regulation of type 2 immune response
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005783cellular_componentendoplasmic reticulum
I0005794cellular_componentGolgi apparatus
I0005815cellular_componentmicrotubule organizing center
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0006954biological_processinflammatory response
I0007231biological_processosmosensory signaling pathway
I0009595biological_processdetection of biotic stimulus
I0014070biological_processresponse to organic cyclic compound
I0016020cellular_componentmembrane
I0016787molecular_functionhydrolase activity
I0016887molecular_functionATP hydrolysis activity
I0031021cellular_componentinterphase microtubule organizing center
I0032731biological_processpositive regulation of interleukin-1 beta production
I0032736biological_processpositive regulation of interleukin-13 production
I0032753biological_processpositive regulation of interleukin-4 production
I0032754biological_processpositive regulation of interleukin-5 production
I0035591molecular_functionsignaling adaptor activity
I0043531molecular_functionADP binding
I0043565molecular_functionsequence-specific DNA binding
I0044546biological_processNLRP3 inflammasome complex assembly
I0045087biological_processinnate immune response
I0045471biological_processresponse to ethanol
I0045630biological_processpositive regulation of T-helper 2 cell differentiation
I0045944biological_processpositive regulation of transcription by RNA polymerase II
I0050727biological_processregulation of inflammatory response
I0050729biological_processpositive regulation of inflammatory response
I0050830biological_processdefense response to Gram-positive bacterium
I0051260biological_processprotein homooligomerization
I0051607biological_processdefense response to virus
I0061702cellular_componentcanonical inflammasome complex
I0070269biological_processpyroptotic inflammatory response
I0070273molecular_functionphosphatidylinositol-4-phosphate binding
I0071222biological_processcellular response to lipopolysaccharide
I0071224biological_processcellular response to peptidoglycan
I0072559cellular_componentNLRP3 inflammasome complex
I0140297molecular_functionDNA-binding transcription factor binding
I0140299molecular_functionsmall molecule sensor activity
I1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
I1901981molecular_functionphosphatidylinositol phosphate binding
I2000321biological_processpositive regulation of T-helper 17 cell differentiation
I2000553biological_processpositive regulation of T-helper 2 cell cytokine production
J0000139cellular_componentGolgi membrane
J0002221biological_processpattern recognition receptor signaling pathway
J0002523biological_processleukocyte migration involved in inflammatory response
J0002526biological_processacute inflammatory response
J0002674biological_processnegative regulation of acute inflammatory response
J0002720biological_processpositive regulation of cytokine production involved in immune response
J0002830biological_processpositive regulation of type 2 immune response
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005783cellular_componentendoplasmic reticulum
J0005794cellular_componentGolgi apparatus
J0005815cellular_componentmicrotubule organizing center
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0006954biological_processinflammatory response
J0007231biological_processosmosensory signaling pathway
J0009595biological_processdetection of biotic stimulus
J0014070biological_processresponse to organic cyclic compound
J0016020cellular_componentmembrane
J0016787molecular_functionhydrolase activity
J0016887molecular_functionATP hydrolysis activity
J0031021cellular_componentinterphase microtubule organizing center
J0032731biological_processpositive regulation of interleukin-1 beta production
J0032736biological_processpositive regulation of interleukin-13 production
J0032753biological_processpositive regulation of interleukin-4 production
J0032754biological_processpositive regulation of interleukin-5 production
J0035591molecular_functionsignaling adaptor activity
J0043531molecular_functionADP binding
J0043565molecular_functionsequence-specific DNA binding
J0044546biological_processNLRP3 inflammasome complex assembly
J0045087biological_processinnate immune response
J0045471biological_processresponse to ethanol
J0045630biological_processpositive regulation of T-helper 2 cell differentiation
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0050727biological_processregulation of inflammatory response
J0050729biological_processpositive regulation of inflammatory response
J0050830biological_processdefense response to Gram-positive bacterium
J0051260biological_processprotein homooligomerization
J0051607biological_processdefense response to virus
J0061702cellular_componentcanonical inflammasome complex
J0070269biological_processpyroptotic inflammatory response
J0070273molecular_functionphosphatidylinositol-4-phosphate binding
J0071222biological_processcellular response to lipopolysaccharide
J0071224biological_processcellular response to peptidoglycan
J0072559cellular_componentNLRP3 inflammasome complex
J0140297molecular_functionDNA-binding transcription factor binding
J0140299molecular_functionsmall molecule sensor activity
J1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
J1901981molecular_functionphosphatidylinositol phosphate binding
J2000321biological_processpositive regulation of T-helper 17 cell differentiation
J2000553biological_processpositive regulation of T-helper 2 cell cytokine production
K0000139cellular_componentGolgi membrane
K0002221biological_processpattern recognition receptor signaling pathway
K0002523biological_processleukocyte migration involved in inflammatory response
K0002526biological_processacute inflammatory response
K0002674biological_processnegative regulation of acute inflammatory response
K0002720biological_processpositive regulation of cytokine production involved in immune response
K0002830biological_processpositive regulation of type 2 immune response
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005783cellular_componentendoplasmic reticulum
K0005794cellular_componentGolgi apparatus
K0005815cellular_componentmicrotubule organizing center
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0006954biological_processinflammatory response
K0007231biological_processosmosensory signaling pathway
K0009595biological_processdetection of biotic stimulus
K0014070biological_processresponse to organic cyclic compound
K0016020cellular_componentmembrane
K0016787molecular_functionhydrolase activity
K0016887molecular_functionATP hydrolysis activity
K0031021cellular_componentinterphase microtubule organizing center
K0032731biological_processpositive regulation of interleukin-1 beta production
K0032736biological_processpositive regulation of interleukin-13 production
K0032753biological_processpositive regulation of interleukin-4 production
K0032754biological_processpositive regulation of interleukin-5 production
K0035591molecular_functionsignaling adaptor activity
K0043531molecular_functionADP binding
K0043565molecular_functionsequence-specific DNA binding
K0044546biological_processNLRP3 inflammasome complex assembly
K0045087biological_processinnate immune response
K0045471biological_processresponse to ethanol
K0045630biological_processpositive regulation of T-helper 2 cell differentiation
K0045944biological_processpositive regulation of transcription by RNA polymerase II
K0050727biological_processregulation of inflammatory response
K0050729biological_processpositive regulation of inflammatory response
K0050830biological_processdefense response to Gram-positive bacterium
K0051260biological_processprotein homooligomerization
K0051607biological_processdefense response to virus
K0061702cellular_componentcanonical inflammasome complex
K0070269biological_processpyroptotic inflammatory response
K0070273molecular_functionphosphatidylinositol-4-phosphate binding
K0071222biological_processcellular response to lipopolysaccharide
K0071224biological_processcellular response to peptidoglycan
K0072559cellular_componentNLRP3 inflammasome complex
K0140297molecular_functionDNA-binding transcription factor binding
K0140299molecular_functionsmall molecule sensor activity
K1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
K1901981molecular_functionphosphatidylinositol phosphate binding
K2000321biological_processpositive regulation of T-helper 17 cell differentiation
K2000553biological_processpositive regulation of T-helper 2 cell cytokine production
L0000139cellular_componentGolgi membrane
L0002221biological_processpattern recognition receptor signaling pathway
L0002523biological_processleukocyte migration involved in inflammatory response
L0002526biological_processacute inflammatory response
L0002674biological_processnegative regulation of acute inflammatory response
L0002720biological_processpositive regulation of cytokine production involved in immune response
L0002830biological_processpositive regulation of type 2 immune response
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005783cellular_componentendoplasmic reticulum
L0005794cellular_componentGolgi apparatus
L0005815cellular_componentmicrotubule organizing center
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0006954biological_processinflammatory response
L0007231biological_processosmosensory signaling pathway
L0009595biological_processdetection of biotic stimulus
L0014070biological_processresponse to organic cyclic compound
L0016020cellular_componentmembrane
L0016787molecular_functionhydrolase activity
L0016887molecular_functionATP hydrolysis activity
L0031021cellular_componentinterphase microtubule organizing center
L0032731biological_processpositive regulation of interleukin-1 beta production
L0032736biological_processpositive regulation of interleukin-13 production
L0032753biological_processpositive regulation of interleukin-4 production
L0032754biological_processpositive regulation of interleukin-5 production
L0035591molecular_functionsignaling adaptor activity
L0043531molecular_functionADP binding
L0043565molecular_functionsequence-specific DNA binding
L0044546biological_processNLRP3 inflammasome complex assembly
L0045087biological_processinnate immune response
L0045471biological_processresponse to ethanol
L0045630biological_processpositive regulation of T-helper 2 cell differentiation
L0045944biological_processpositive regulation of transcription by RNA polymerase II
L0050727biological_processregulation of inflammatory response
L0050729biological_processpositive regulation of inflammatory response
L0050830biological_processdefense response to Gram-positive bacterium
L0051260biological_processprotein homooligomerization
L0051607biological_processdefense response to virus
L0061702cellular_componentcanonical inflammasome complex
L0070269biological_processpyroptotic inflammatory response
L0070273molecular_functionphosphatidylinositol-4-phosphate binding
L0071222biological_processcellular response to lipopolysaccharide
L0071224biological_processcellular response to peptidoglycan
L0072559cellular_componentNLRP3 inflammasome complex
L0140297molecular_functionDNA-binding transcription factor binding
L0140299molecular_functionsmall molecule sensor activity
L1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
L1901981molecular_functionphosphatidylinositol phosphate binding
L2000321biological_processpositive regulation of T-helper 17 cell differentiation
L2000553biological_processpositive regulation of T-helper 2 cell cytokine production
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:35254907, ECO:0007744|PDB:7VTQ
ChainResidueDetails
ATHR165
JTHR165
KTHR165
LTHR165
BTHR165
CTHR165
DTHR165
ETHR165
FTHR165
GTHR165
HTHR165
ITHR165

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00136, ECO:0000305|PubMed:35254907, ECO:0007744|PDB:7VTQ
ChainResidueDetails
AGLY222
JGLY222
KGLY222
LGLY222
BGLY222
CGLY222
DGLY222
EGLY222
FGLY222
GGLY222
HGLY222
IGLY222

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q96P20
ChainResidueDetails
AHIS518
JHIS518
KHIS518
LHIS518
BHIS518
CHIS518
DHIS518
EHIS518
FHIS518
GHIS518
HHIS518
IHIS518

site_idSWS_FT_FI4
Number of Residues36
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:28465465
ChainResidueDetails
ASER3
DSER3
DSER157
DSER725
ESER3
ESER157
ESER725
FSER3
FSER157
FSER725
GSER3
ASER157
GSER157
GSER725
HSER3
HSER157
HSER725
ISER3
ISER157
ISER725
JSER3
JSER157
ASER725
JSER725
KSER3
KSER157
KSER725
LSER3
LSER157
LSER725
BSER3
BSER157
BSER725
CSER3
CSER157
CSER725

site_idSWS_FT_FI5
Number of Residues24
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q96P20
ChainResidueDetails
ATYR11
ETYR858
FTYR11
FTYR858
GTYR11
GTYR858
HTYR11
HTYR858
ITYR11
ITYR858
JTYR11
ATYR858
JTYR858
KTYR11
KTYR858
LTYR11
LTYR858
BTYR11
BTYR858
CTYR11
CTYR858
DTYR11
DTYR858
ETYR11

site_idSWS_FT_FI6
Number of Residues48
DetailsMOD_RES: Phosphotyrosine; by BTK => ECO:0000269|PubMed:34554188
ChainResidueDetails
ATYR132
CTYR136
CTYR145
CTYR164
DTYR132
DTYR136
DTYR145
DTYR164
ETYR132
ETYR136
ETYR145
ATYR136
ETYR164
FTYR132
FTYR136
FTYR145
FTYR164
GTYR132
GTYR136
GTYR145
GTYR164
HTYR132
ATYR145
HTYR136
HTYR145
HTYR164
ITYR132
ITYR136
ITYR145
ITYR164
JTYR132
JTYR136
JTYR145
ATYR164
JTYR164
KTYR132
KTYR136
KTYR145
KTYR164
LTYR132
LTYR136
LTYR145
LTYR164
BTYR132
BTYR136
BTYR145
BTYR164
CTYR132

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:28943315
ChainResidueDetails
ASER194
JSER194
KSER194
LSER194
BSER194
CSER194
DSER194
ESER194
FSER194
GSER194
HSER194
ISER194

site_idSWS_FT_FI8
Number of Residues48
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96P20
ChainResidueDetails
ASER197
CSER330
CSER732
CSER1032
DSER197
DSER330
DSER732
DSER1032
ESER197
ESER330
ESER732
ASER330
ESER1032
FSER197
FSER330
FSER732
FSER1032
GSER197
GSER330
GSER732
GSER1032
HSER197
ASER732
HSER330
HSER732
HSER1032
ISER197
ISER330
ISER732
ISER1032
JSER197
JSER330
JSER732
ASER1032
JSER1032
KSER197
KSER330
KSER732
KSER1032
LSER197
LSER330
LSER732
LSER1032
BSER197
BSER330
BSER732
BSER1032
CSER197

site_idSWS_FT_FI9
Number of Residues12
DetailsMOD_RES: Phosphoserine; by PKD/PRKD1 => ECO:0000269|PubMed:28716882
ChainResidueDetails
ASER291
JSER291
KSER291
LSER291
BSER291
CSER291
DSER291
ESER291
FSER291
GSER291
HSER291
ISER291

site_idSWS_FT_FI10
Number of Residues12
DetailsMOD_RES: Phosphoserine; by CSNK1A1 => ECO:0000269|PubMed:34615873
ChainResidueDetails
ASER803
JSER803
KSER803
LSER803
BSER803
CSER803
DSER803
ESER803
FSER803
GSER803
HSER803
ISER803

site_idSWS_FT_FI11
Number of Residues36
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q96P20
ChainResidueDetails
ACYS834
DCYS834
DCYS835
DCYS841
ECYS834
ECYS835
ECYS841
FCYS834
FCYS835
FCYS841
GCYS834
ACYS835
GCYS835
GCYS841
HCYS834
HCYS835
HCYS841
ICYS834
ICYS835
ICYS841
JCYS834
JCYS835
ACYS841
JCYS841
KCYS834
KCYS835
KCYS841
LCYS834
LCYS835
LCYS841
BCYS834
BCYS835
BCYS841
CCYS834
CCYS835
CCYS841

site_idSWS_FT_FI12
Number of Residues48
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q96P20
ChainResidueDetails
ALYS687
CLYS875
CLYS970
DLYS687
DLYS875
DLYS970
ELYS687
ELYS875
ELYS970
FLYS687
FLYS875
FLYS970
GLYS687
GLYS875
GLYS970
HLYS687
ALYS875
HLYS875
HLYS970
ILYS687
ILYS875
ILYS970
JLYS687
JLYS875
ALYS970
JLYS970
KLYS687
KLYS875
KLYS970
LLYS687
LLYS875
LLYS970
BLYS687
BLYS875
BLYS970
CLYS687

223166

PDB entries from 2024-07-31

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