5Z56
| cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | Deposit date: | 2018-01-17 | Release date: | 2018-09-19 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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5Z58
| Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | Deposit date: | 2018-01-17 | Release date: | 2018-09-19 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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5Z57
| Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ALANINE, BUD13 homolog, ... | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | Deposit date: | 2018-01-17 | Release date: | 2018-09-19 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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7EXS
| Thermomicrobium roseum sarcosine oxidase mutant - S320R | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Xin, Y, Shen, C, Tang, M.W, Shi, Y, Guo, Z.T, Gu, Z.H, Shao, J, Zhang, L. | Deposit date: | 2021-05-28 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Recreating the natural evolutionary trend in key microdomains provides an effective strategy for engineering of a thermomicrobial N-demethylase. J.Biol.Chem., 298, 2022
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6A70
| Structure of the human PKD1/PKD2 complex | Descriptor: | Polycystin-1, Polycystin-2 | Authors: | Su, Q, Hu, F, Ge, X, Lei, J, Yu, S, Wang, T, Zhou, Q, Mei, C, Shi, Y. | Deposit date: | 2018-06-29 | Release date: | 2018-08-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of the human PKD1-PKD2 complex. Science, 361, 2018
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5ZWO
| Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 23 kDa U4/U6.U5 small nuclear ribonucleoprotein component, 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, ... | Authors: | Bai, R, Wan, R, Yan, C, Shi, Y. | Deposit date: | 2018-05-16 | Release date: | 2018-08-29 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation Science, 360, 2018
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5ZWN
| Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.3 angstrom (Part II: U1 snRNP region) | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, Pre-mRNA-processing factor 39, Pre-mRNA-splicing ATP-dependent RNA helicase PRP28, ... | Authors: | Bai, R, Wan, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2018-05-16 | Release date: | 2018-08-29 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation Science, 360, 2018
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6AAX
| Crystal structure of TFB1M and h45 with SAM in homo sapiens | Descriptor: | DI(HYDROXYETHYL)ETHER, Dimethyladenosine transferase 1, mitochondrial, ... | Authors: | Liu, X, Shen, S, Wu, P, Li, F, Gong, Q, Wu, J, Zhang, H, Shi, Y. | Deposit date: | 2018-07-19 | Release date: | 2019-06-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.994 Å) | Cite: | Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res., 47, 2019
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5ZWM
| Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part) | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Cold sensitive U2 snRNA suppressor 1, ... | Authors: | Bai, R, Wan, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2018-05-16 | Release date: | 2018-08-29 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation Science, 360, 2018
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6AH0
| The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhan, X, Yan, C, Zhang, X, Shi, Y. | Deposit date: | 2018-08-15 | Release date: | 2018-11-14 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res., 28, 2018
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7BCS
| ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation. | Descriptor: | (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7EVN
| The cryo-EM structure of the DDX42-SF3b complex | Descriptor: | ATP-dependent RNA helicase DDX42, PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome Nat.Struct.Mol.Biol., 2024
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7EVO
| The cryo-EM structure of the human 17S U2 snRNP | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
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2L3T
| Solution structure of tandem SH2 domain from Spt6 | Descriptor: | Transcription elongation factor SPT6 | Authors: | Liu, J, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2010-09-22 | Release date: | 2011-06-15 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain To be Published
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7CTT
| Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Peng, Q, Peng, R, Shi, Y. | Deposit date: | 2020-08-20 | Release date: | 2020-09-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir. Innovation (N Y), 2, 2021
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7DVQ
| Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | Authors: | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | Deposit date: | 2021-01-14 | Release date: | 2021-03-31 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure of the activated human minor spliceosome. Science, 371, 2021
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7DCR
| cryo-EM structure of the DEAH-box helicase Prp2 in complex with its coactivator Spp2 | Descriptor: | PRP2 isoform 1, Pre-mRNA-splicing factor SPP2 | Authors: | Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y. | Deposit date: | 2020-10-26 | Release date: | 2021-01-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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7DCQ
| cryo-EM structure of the DEAH-box helicase Prp2 | Descriptor: | PRP2 isoform 1 | Authors: | Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y. | Deposit date: | 2020-10-26 | Release date: | 2021-01-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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7DCO
| Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom | Descriptor: | BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ... | Authors: | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | Deposit date: | 2020-10-26 | Release date: | 2021-03-17 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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7BCT
| ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation. | Descriptor: | Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BCQ
| ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation. | Descriptor: | 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7D8X
| CryoEM structure of human gamma-secretase in complex with E2012 and L685458 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2020-10-11 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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7DD3
| Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2 | Descriptor: | PRP2 isoform 1, Pre-mRNA-splicing factor SPP2, pre-mRNA | Authors: | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | Deposit date: | 2020-10-27 | Release date: | 2021-01-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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7DCP
| cryo-EM structure of the DEAH-box helicase Prp2 and coactivator Spp2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PRP2 isoform 1, ... | Authors: | Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y. | Deposit date: | 2020-10-26 | Release date: | 2021-01-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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7EP7
| The complex structure of Gpsm2 and Whirlin | Descriptor: | G-protein-signaling modulator 2, Whirlin | Authors: | Lin, L, Shi, Y, Wang, C, Zhu, J. | Deposit date: | 2021-04-26 | Release date: | 2022-05-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Promotion of row 1-specific tip complex condensates by Gpsm2-G alpha i provides insights into row identity of the tallest stereocilia. Sci Adv, 8, 2022
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