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PDB: 1971 results

8Y6O
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BU of 8y6o by Molmil
Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Centrosomal AT-AC splicing factor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R.
Deposit date:2024-02-02
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.
Science, 383, 2024
8X52
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BU of 8x52 by Molmil
Cryo-EM structure of human gamma-secretase in complex with Abeta49
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-11-16
Release date:2024-05-29
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
4YY0
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BU of 4yy0 by Molmil
The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HA1, HA2
Authors:Wang, F, Qi, J, Bi, Y, Zhang, W, Wang, M, Wang, M, Liu, J, Yan, J, Shi, Y, Gao, G.F.
Deposit date:2015-03-23
Release date:2016-03-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013)
To Be Published
3C5W
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BU of 3c5w by Molmil
Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme
Descriptor: PP2A A subunit, PP2A C subunit, PP2A-specific methylesterase PME-1
Authors:Xing, Y, Li, Z, Chen, Y, Stock, J, Jeffrey, P.D, Shi, Y.
Deposit date:2008-02-01
Release date:2008-04-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Cell(Cambridge,Mass.), 133, 2008
3C5V
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BU of 3c5v by Molmil
PP2A-specific methylesterase apo form (PME)
Descriptor: Protein phosphatase methylesterase 1
Authors:Xing, Y, Li, Z, Chen, Y, Stock, J, Jeffrey, P.D, Shi, Y.
Deposit date:2008-02-01
Release date:2008-04-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Cell(Cambridge,Mass.), 133, 2008
8HG1
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BU of 8hg1 by Molmil
The structure of MPXV polymerase holoenzyme in replicating state
Descriptor: DNA (25-MER), DNA (38-MER), DNA polymerase, ...
Authors:Peng, Q, Xie, Y.F, Kuai, L, Wang, H, Qi, J.X, Gao, F, Shi, Y.
Deposit date:2022-11-13
Release date:2022-12-21
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of monkeypox virus DNA polymerase holoenzyme.
Science, 379, 2023
4NS5
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BU of 4ns5 by Molmil
Crystal structure of human BS69 Bromo-Zinc finger-PWWP
Descriptor: ZINC ION, Zinc finger MYND domain-containing protein 11
Authors:Wang, J.C, Qin, S, Li, F.D, Li, S, Zhang, W, Wu, J.H, Shi, Y.Y.
Deposit date:2013-11-28
Release date:2014-04-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding.
Cell Res., 24, 2014
3GYP
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BU of 3gyp by Molmil
Rtt106p
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, Histone chaperone RTT106
Authors:Liu, Y, Huang, H, Shi, Y, Teng, M.
Deposit date:2009-04-04
Release date:2009-12-08
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.406 Å)
Cite:Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing
J.Biol.Chem., 285, 2010
5JNX
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BU of 5jnx by Molmil
The 6.6 A cryo-EM structure of the full-length human NPC1 in complex with the cleaved glycoprotein of Ebola virus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, ...
Authors:Gong, X, Qian, H.W, Zhou, X.H, Wu, J.P, Wan, T, Shi, Y, Gao, F, Zhou, Q, Yan, N.
Deposit date:2016-05-01
Release date:2016-06-15
Last modified:2020-08-05
Method:ELECTRON MICROSCOPY (6.56 Å)
Cite:Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
Cell, 165, 2016
5GJQ
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BU of 5gjq by Molmil
Structure of the human 26S proteasome bound to USP14-UbAl
Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ...
Authors:Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G.
Deposit date:2016-07-01
Release date:2016-08-17
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:An atomic structure of the human 26S proteasome.
Nat. Struct. Mol. Biol., 23, 2016
3GYO
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BU of 3gyo by Molmil
Se-Met Rtt106p
Descriptor: Histone chaperone RTT106
Authors:Liu, Y, Huang, H, Shi, Y, Teng, M.
Deposit date:2009-04-04
Release date:2009-12-08
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing
J.Biol.Chem., 285, 2010
3DW8
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BU of 3dw8 by Molmil
Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Xu, Y, Chen, Y, Zhang, P, Jeffrey, P.D, Shi, Y.
Deposit date:2008-07-21
Release date:2008-10-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
Mol.Cell, 31, 2008
4RDO
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BU of 4rdo by Molmil
Structure of YTH-YTHDF2 in the free state
Descriptor: SULFATE ION, YTH domain-containing family protein 2
Authors:Li, F.D, Zhao, D.B, Wu, J.H, Shi, Y.Y.
Deposit date:2014-09-19
Release date:2014-12-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition.
Cell Res., 24, 2014
4RDN
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BU of 4rdn by Molmil
Structure of YTH-YTHDF2 in complex with m6A
Descriptor: N-methyladenosine, SULFATE ION, YTH domain-containing family protein 2
Authors:Li, F.D, Zhao, D.B, Wu, J.H, Shi, Y.Y.
Deposit date:2014-09-19
Release date:2014-12-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition.
Cell Res., 24, 2014
7T0D
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BU of 7t0d by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2k
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-propyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.906 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T0C
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BU of 7t0c by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2e
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-chlorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T0E
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BU of 7t0e by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2b
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-(3-chlorophenyl)piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.223 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T0B
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BU of 7t0b by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2g
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-fluorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T0A
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BU of 7t0a by Molmil
Cryptococcus neoformans protein farnesyltransferase co-crystallized with FPP and inhibitor 2f
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T09
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BU of 7t09 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2d
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}benzonitrile, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.984 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T08
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BU of 7t08 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2q
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}-2-fluorobenzonitrile, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
3AL4
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BU of 3al4 by Molmil
Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:Zhang, W, Qi, J.X, Shi, Y, Li, Q, Yan, J.H, Gao, G.F.
Deposit date:2010-07-22
Release date:2010-08-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.872 Å)
Cite:Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus
Protein Cell, 1, 2010
7XQ8
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BU of 7xq8 by Molmil
Structure of human B-cell antigen receptor of the IgM isotype
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, ...
Authors:Chen, M.Y, Su, Q, Shi, Y.G.
Deposit date:2022-05-07
Release date:2022-08-17
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of the human IgM B cell receptor.
Science, 377, 2022
8HMY
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BU of 8hmy by Molmil
Cryo-EM structure of the human pre-catalytic TSEN/pre-tRNA complex
Descriptor: Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ...
Authors:Zhang, X, Yang, F, Zhan, X, Shi, Y.
Deposit date:2022-12-06
Release date:2023-04-19
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
Mol.Cell, 83, 2023
8HMZ
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BU of 8hmz by Molmil
Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex
Descriptor: Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ...
Authors:Zhang, X, Yang, F, Zhan, X, Shi, Y.
Deposit date:2022-12-06
Release date:2023-04-19
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
Mol.Cell, 83, 2023

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數據於2024-07-24公開中

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