8HMY

Cryo-EM structure of the human pre-catalytic TSEN/pre-tRNA complex

Summary for 8HMY

• Entry DOI: 10.2210/pdb8hmy/pdb
• EMDB information: 34904
• Descriptor: tRNA-splicing endonuclease subunit Sen2, tRNA-splicing endonuclease subunit Sen34, Pre-tRNA, ... (7 entities in total)
• Functional Keywords: pre-trna splicing, tsen, pre-trna, rna binding protein/rna, rna binding protein-rna complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 261762.94

Authors

Zhang, X.,Yang, F.,Zhan, X.,Shi, Y. (deposition date: 2022-12-06, release date: 2023-04-19, Last modification date: 2023-05-03)

• Primary citation: Zhang, X.,Yang, F.,Zhan, X.,Bian, T.,Xing, Z.,Lu, Y.,Shi, Y.; Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.; Mol.Cell, 83:1328-1339.e4, 2023; PubMed: 37028420; DOI: 10.1016/j.molcel.2023.03.015

Experimental method

ELECTRON MICROSCOPY (2.94 Å)