8HMY
Cryo-EM structure of the human pre-catalytic TSEN/pre-tRNA complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | tRNA-splicing endonuclease subunit Sen2 | polymer | 485 | 55391.9 | 1 | UniProt (Q8NCE0) Pfam (PF02778) Pfam (PF01974) In PDB | Homo sapiens (human) | tRNA-intron endonuclease Sen2,HsSen2 |
2 | B | tRNA-splicing endonuclease subunit Sen34 | polymer | 330 | 35759.9 | 1 | UniProt (Q9BSV6) Pfam (PF01974) In PDB | Homo sapiens (human) | Leukocyte receptor cluster member 5,tRNA-intron endonuclease Sen34,HsSen34 |
3 | T | Pre-tRNA | polymer | 114 | 36798.8 | 1 | Homo sapiens | ||
4 | C | tRNA-splicing endonuclease subunit Sen54 | polymer | 546 | 61032.3 | 1 | UniProt (Q7Z6J9) Pfam (PF12928) In PDB | Homo sapiens (human) | SEN54 homolog,HsSEN54,tRNA-intron endonuclease Sen54 |
5 | D | Chromosome 1 open reading frame 19, isoform CRA_a | polymer | 213 | 22796.6 | 1 | UniProt (A0A2U3TZM3) Pfam (PF09631) UniProt (by SIFTS) (Q8WW01) In PDB | Homo sapiens (human) | tRNA-splicing endonuclease subunit Sen15 |
6 | E | Polyribonucleotide 5'-hydroxyl-kinase Clp1 | polymer | 445 | 49837.5 | 1 | UniProt (Q92989) Pfam (PF16573) Pfam (PF16575) Pfam (PF06807) In PDB | Homo sapiens (human) | Polyadenylation factor Clp1,Polynucleotide kinase Clp1,Pre-mRNA cleavage complex II protein Clp1 |
7 | T | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) |
Sequence modifications
A: 1 - 465 (UniProt: Q8NCE0)
B: 1 - 310 (UniProt: Q9BSV6)
C: 1 - 526 (UniProt: Q7Z6J9)
D: 1 - 175 (UniProt: A0A2U3TZM3)
E: 1 - 425 (UniProt: Q92989)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Ala -18 | - | expression tag |
Ser -17 | - | expression tag |
Asp -16 | - | expression tag |
Tyr -15 | - | expression tag |
Lys -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Asp -11 | - | expression tag |
Asp -10 | - | expression tag |
Lys -9 | - | expression tag |
Ala -8 | - | expression tag |
Ser -7 | - | expression tag |
Asp -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Gly -1 | - | expression tag |
Thr 0 | - | expression tag |
Ala 377 | His 377 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Ala -18 | - | expression tag |
Ser -17 | - | expression tag |
Asp -16 | - | expression tag |
Tyr -15 | - | expression tag |
Lys -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Asp -11 | - | expression tag |
Asp -10 | - | expression tag |
Lys -9 | - | expression tag |
Ala -8 | - | expression tag |
Ser -7 | - | expression tag |
Asp -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Gly -1 | - | expression tag |
Thr 0 | - | expression tag |
Ala 255 | His 255 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Ala -18 | - | expression tag |
Ser -17 | - | expression tag |
Asp -16 | - | expression tag |
Tyr -15 | - | expression tag |
Lys -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Asp -11 | - | expression tag |
Asp -10 | - | expression tag |
Lys -9 | - | expression tag |
Ala -8 | - | expression tag |
Ser -7 | - | expression tag |
Asp -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Gly -1 | - | expression tag |
Thr 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -37 | - | initiating methionine |
Ala -36 | - | expression tag |
Ser -35 | - | expression tag |
Ser -34 | - | expression tag |
Ala -33 | - | expression tag |
Trp -32 | - | expression tag |
Ser -31 | - | expression tag |
His -30 | - | expression tag |
Pro -29 | - | expression tag |
Gln -28 | - | expression tag |
Phe -27 | - | expression tag |
Glu -26 | - | expression tag |
Lys -25 | - | expression tag |
Gly -24 | - | expression tag |
Gly -23 | - | expression tag |
Gly -22 | - | expression tag |
Ser -21 | - | expression tag |
Gly -20 | - | expression tag |
Gly -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Gly -16 | - | expression tag |
Gly -15 | - | expression tag |
Ser -14 | - | expression tag |
Ala -13 | - | expression tag |
Trp -12 | - | expression tag |
Ser -11 | - | expression tag |
His -10 | - | expression tag |
Pro -9 | - | expression tag |
Gln -8 | - | expression tag |
Phe -7 | - | expression tag |
Glu -6 | - | expression tag |
Lys -5 | - | expression tag |
Gly -4 | - | expression tag |
Ser -3 | - | expression tag |
Ala -2 | - | expression tag |
Ala -1 | - | expression tag |
Ala 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Ala -18 | - | expression tag |
Ser -17 | - | expression tag |
Asp -16 | - | expression tag |
Tyr -15 | - | expression tag |
Lys -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Asp -11 | - | expression tag |
Asp -10 | - | expression tag |
Lys -9 | - | expression tag |
Ala -8 | - | expression tag |
Ser -7 | - | expression tag |
Asp -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Gly -1 | - | expression tag |
Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 261617.1 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 145.8 | |
All* | Total formula weight | 261762.9 |