7T08

Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2q

Summary for 7T08

Entry DOI	10.2210/pdb7t08/pdb
Related	7T09 7T0A 7T0B 7T0C 7T0D 7T0E
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, 1,2-ETHANEDIOL, ... (8 entities in total)
Functional Keywords	inhibitor, antifungal, transferase, transferase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) More
Total number of polymer chains	2
Total formula weight	102947.20
Authors	Wang, Y.,Shi, Y.,Beese, L.S. (deposition date: 2021-11-29, release date: 2022-11-09, Last modification date: 2023-10-18)
Primary citation	Wang, Y.,Xu, F.,Nichols, C.B.,Shi, Y.,Hellinga, H.W.,Alspaugh, J.A.,Distefano, M.D.,Beese, L.S. Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65:13753-13770, 2022 Cited by PubMed: 36218371 DOI: 10.1021/acs.jmedchem.2c00902 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.803 Å)

Structure validation