7T08
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2q
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | polymer | 349 | 40913.2 | 1 | UniProt (J9VSJ6) Pfam (PF01239) | Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha,variant |
| 2 | B (B) | Protein farnesyltransferase subunit beta | polymer | 520 | 56806.9 | 1 | UniProt (T2BPA1) Pfam (PF00432) | Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) | FTase-beta |
| 3 | AA, AB, BA, BB, C... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 57 | Chemie (EDO) | |||
| 4 | EA (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | FA, GA, HA (B) | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid | non-polymer | 237.3 | 3 | Chemie (3FX) | |||
| 6 | FB (B) | 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}-2-fluorobenzonitrile | non-polymer | 529.5 | 1 | Chemie (XO1) | |||
| 7 | GB (B) | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 8 | NB, OB (A, B) | water | water | 18.0 | 673 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: J9VSJ6)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Leu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97720.1 | |
| Non-Polymers* | Number of molecules | 63 |
| Total formula weight | 5227.1 | |
| All* | Total formula weight | 102947.2 |
