6NQ2
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![BU of 6nq2 by Molmil](/molmil-images/mine/6nq2) | Cryo-EM structure of human TPC2 channel in the ligand-bound closed state | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | Authors: | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | Deposit date: | 2019-01-18 | Release date: | 2019-03-27 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8, 2019
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6NQ1
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![BU of 6nq1 by Molmil](/molmil-images/mine/6nq1) | Cryo-EM structure of human TPC2 channel in the apo state | Descriptor: | Two pore calcium channel protein 2 | Authors: | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | Deposit date: | 2019-01-18 | Release date: | 2019-03-27 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8, 2019
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6NQ0
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![BU of 6nq0 by Molmil](/molmil-images/mine/6nq0) | Cryo-EM structure of human TPC2 channel in the ligand-bound open state | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | Authors: | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | Deposit date: | 2019-01-18 | Release date: | 2019-03-27 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8, 2019
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6C9A
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![BU of 6c9a by Molmil](/molmil-images/mine/6c9a) | Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | She, J, Guo, J, Chen, Q, Bai, X, Jiang, Y. | Deposit date: | 2018-01-25 | Release date: | 2018-04-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel. Nature, 556, 2018
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6C96
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![BU of 6c96 by Molmil](/molmil-images/mine/6c96) | Cryo-EM structure of mouse TPC1 channel in the apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | Authors: | She, J, Guo, J, Chen, Q, Bai, X, Jiang, Y. | Deposit date: | 2018-01-25 | Release date: | 2018-04-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel. Nature, 556, 2018
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8IOW
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![BU of 8iow by Molmil](/molmil-images/mine/8iow) | |
8J6F
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![BU of 8j6f by Molmil](/molmil-images/mine/8j6f) | Cryo-EM structure of the Tocilizumab Fab/IL-6R complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Tocilizumab Fab, IL6R-D2 peptide, ... | Authors: | She, J, Chen, L. | Deposit date: | 2023-04-25 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of tocilizumab and sarilumab Fabs in complex with IL-6R To Be Published
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7YTW
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![BU of 7ytw by Molmil](/molmil-images/mine/7ytw) | Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter | Descriptor: | ASCORBIC ACID, SODIUM ION, Solute carrier family 23 member 1 | Authors: | She, J, Wang, M, He, J, Zhang, K, Li, S. | Deposit date: | 2022-08-16 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter. Nat Commun, 14, 2023
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7YTY
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![BU of 7yty by Molmil](/molmil-images/mine/7yty) | Mouse SVCT1 in an apo state | Descriptor: | Solute carrier family 23 member 1 | Authors: | She, J, Wang, M, He, J, Zhang, K, Li, S. | Deposit date: | 2022-08-16 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter. Nat Commun, 14, 2023
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5JJD
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![BU of 5jjd by Molmil](/molmil-images/mine/5jjd) | |
6WF2
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![BU of 6wf2 by Molmil](/molmil-images/mine/6wf2) | Crystal structure of mouse SCD1 with a diiron center | Descriptor: | Acyl-CoA desaturase 1, FE (III) ION, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | Authors: | Shen, J, Zhou, M. | Deposit date: | 2020-04-03 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase. J.Mol.Biol., 432, 2020
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8HZ5
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![BU of 8hz5 by Molmil](/molmil-images/mine/8hz5) | |
8HZ4
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![BU of 8hz4 by Molmil](/molmil-images/mine/8hz4) | |
4HHV
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![BU of 4hhv by Molmil](/molmil-images/mine/4hhv) | Crystal structure of ceramide transfer protein pleckstrin homology domain | Descriptor: | ACETATE ION, CHLORIDE ION, Collagen type IV alpha-3-binding protein, ... | Authors: | Prashek, J, Truong, T, Yao, X. | Deposit date: | 2012-10-10 | Release date: | 2013-11-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structure of the Pleckstrin Homology Domain from the Ceramide Transfer Protein: Implications for Conformational Change upon Ligand Binding. Plos One, 8, 2013
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4HNJ
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![BU of 4hnj by Molmil](/molmil-images/mine/4hnj) | |
5CH0
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![BU of 5ch0 by Molmil](/molmil-images/mine/5ch0) | |
5CJY
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![BU of 5cjy by Molmil](/molmil-images/mine/5cjy) | |
7F6H
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![BU of 7f6h by Molmil](/molmil-images/mine/7f6h) | Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin | Descriptor: | Bradykinin, Bradykinin receptor BK2R, CHOLESTEROL, ... | Authors: | Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H. | Deposit date: | 2021-06-25 | Release date: | 2022-01-05 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Nat Commun, 13, 2022
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7F6I
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![BU of 7f6i by Molmil](/molmil-images/mine/7f6i) | Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin | Descriptor: | Bradykinin receptor BK2R, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H. | Deposit date: | 2021-06-25 | Release date: | 2022-01-05 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Nat Commun, 13, 2022
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5H7P
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![BU of 5h7p by Molmil](/molmil-images/mine/5h7p) | NMR structure of the Vta1NTD-Did2(176-204) complex | Descriptor: | Vacuolar protein sorting-associated protein VTA1, Vacuolar protein-sorting-associated protein 46 | Authors: | Shen, J, Yang, Z, Wild, C.J. | Deposit date: | 2016-11-20 | Release date: | 2016-12-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway Sci Rep, 6, 2016
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5E36
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![BU of 5e36 by Molmil](/molmil-images/mine/5e36) | |
8G3G
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![BU of 8g3g by Molmil](/molmil-images/mine/8g3g) | CryoEM structure of yeast recombination mediator Rad52 | Descriptor: | DNA repair and recombination protein RAD52 | Authors: | Deveryshetty, J, Basore, K, Rau, M, Fitzpatrick, J.A.J, Antony, E. | Deposit date: | 2023-02-07 | Release date: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes. Nat Commun, 14, 2023
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7S8U
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6WIK
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![BU of 6wik by Molmil](/molmil-images/mine/6wik) | Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin | Descriptor: | 11F9 Fab heavy-chain, 11F9 Fab light-chain, Solute carrier family 40 protein | Authors: | Shen, J, Ren, Z, Pan, Y, Gao, S, Yan, N, Zhou, M. | Deposit date: | 2020-04-10 | Release date: | 2020-11-11 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of ion transport and inhibition in ferroportin. Nat Commun, 11, 2020
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8DL7
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![BU of 8dl7 by Molmil](/molmil-images/mine/8dl7) | Cryo-EM structure of human ferroportin/slc40 bound to minihepcidin PR73 in nanodisc | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 11F9 heavy-chain, 11F9 light-chain, ... | Authors: | Shen, J, Wilbon, A.S, Pan, Y, Zhou, M. | Deposit date: | 2022-07-07 | Release date: | 2022-12-07 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis of ferroportin inhibition by minihepcidin PR73. Plos Biol., 21, 2023
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