8DL7

Cryo-EM structure of human ferroportin/slc40 bound to minihepcidin PR73 in nanodisc

Summary for 8DL7

• Entry DOI: 10.2210/pdb8dl7/pdb
• EMDB information: 27498
• Related PRD ID: PRD_002510
• Descriptor: Solute carrier family 40 member 1, 11F9 light-chain, 11F9 heavy-chain, ... (6 entities in total)
• Functional Keywords: slc40, fpn, ferroportin, iron, transporter, hepcidin, minihepcidin, pr73, human, nanodisc, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 115951.90

Authors

Shen, J.,Wilbon, A.S.,Pan, Y.,Zhou, M. (deposition date: 2022-07-07, release date: 2022-12-07, Last modification date: 2023-11-15)

• Primary citation: Wilbon, A.S.,Shen, J.,Ruchala, P.,Zhou, M.,Pan, Y.; Structural basis of ferroportin inhibition by minihepcidin PR73.; Plos Biol., 21:e3001936-e3001936, 2023; PubMed: 36649314; DOI: 10.1371/journal.pbio.3001936

Experimental method

ELECTRON MICROSCOPY (2.7 Å)