6WIK

Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin

Summary for 6WIK

• Entry DOI: 10.2210/pdb6wik/pdb
• Related: 6VYH
• EMDB information: 21460 21684
• Descriptor: 11F9 Fab light-chain, 11F9 Fab heavy-chain, Solute carrier family 40 protein (3 entities in total)
• Functional Keywords: slc40, fpn, ferroportin, iron transporter, hepcidin, membrane protein
• Biological source: Carlito syrichta (Philippine tarsier); More
• Total number of polymer chains: 3
• Total formula weight: 113013.93

Authors

Shen, J.,Ren, Z.,Pan, Y.,Gao, S.,Yan, N.,Zhou, M. (deposition date: 2020-04-10, release date: 2020-11-11, Last modification date: 2022-08-31)

• Primary citation: Pan, Y.,Ren, Z.,Gao, S.,Shen, J.,Wang, L.,Xu, Z.,Yu, Y.,Bachina, P.,Zhang, H.,Fan, X.,Laganowsky, A.,Yan, N.,Zhou, M.; Structural basis of ion transport and inhibition in ferroportin.; Nat Commun, 11:5686-5686, 2020; PubMed: 33173040; DOI: 10.1038/s41467-020-19458-6

Experimental method

ELECTRON MICROSCOPY (3.4 Å)