1QZD
 
 | | EF-Tu.kirromycin coordinates fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome | | 分子名称: | Elongation factor Tu | | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | | 登録日 | 2003-09-16 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (10 Å) | | 主引用文献 | Incorporation of Aminoacyl-tRNA into the Ribosome as seen by Cryo-electron Microscopy
Nat.Struct.Biol., 10, 2003
|
|
1QZA
 | | Coordinates of the A/T site tRNA model fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome | | 分子名称: | Phe-tRNA | | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | | 登録日 | 2003-09-16 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (10 Å) | | 主引用文献 | Incorporation of Aminoacyl-tRNA into the Ribosome as seen by Cryo-electron Microscopy
Nat.Struct.Biol., 10, 2003
|
|
1YNJ
 | | Taq RNA polymerase-Sorangicin complex | | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | 著者 | Campbell, E.A, Pavlova, O, Zenkin, N, Leon, F, Irschik, H, Jansen, R, Severinov, K, Darst, S.A. | | 登録日 | 2005-01-24 | | 公開日 | 2005-03-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
|
|
1R2X
 | | Coordinates of L11 with 58nts of 23S rRNA fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome | | 分子名称: | 50S ribosomal protein L11, 58nts of 23S rRNA | | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | | 登録日 | 2003-09-30 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (9 Å) | | 主引用文献 | Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron Microscopy
Nat.Struct.Biol., 10, 2003
|
|
2Q6M
 | |
2C36
 | | Structure of unliganded HSV gD reveals a mechanism for receptor- mediated activation of virus entry | | 分子名称: | CHLORIDE ION, GLYCOPROTEIN D HSV-1, ZINC ION, ... | | 著者 | Krummenacher, C, Supekar, V.M, Whitbeck, J.C, Lazear, E, Connolly, S.A, Eisenberg, R.J, Cohen, G.H, Wiley, D.C, Carfi, A. | | 登録日 | 2005-10-04 | | 公開日 | 2005-11-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry.
EMBO J., 24, 2005
|
|
2C3A
 | | Structure of unliganded HSV gD reveals a mechanism for receptor- mediated activation of virus entry | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCOPROTEIN D, ... | | 著者 | Krummenacher, C, Supekar, V.M, Whitbeck, J.C, Lazear, E, Connolly, S.A, Eisenberg, R.J, Cohen, G.H, Wiley, D.C, Carfi, A. | | 登録日 | 2005-10-05 | | 公開日 | 2005-12-21 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of Unliganded Hsv Gd Reveals a Mechanism for Receptor-Mediated Activation of Virus Entry.
Embo J., 24, 2005
|
|
1R2W
 | | Coordinates of L11 with 58nts of 23S rRNA fitted into the cryo-EM map of the 70S ribosome | | 分子名称: | 50S ribosomal protein L11, 58nts of 23S rRNA | | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | | 登録日 | 2003-09-30 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (9 Å) | | 主引用文献 | Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron Microscopy
Nat.Struct.Biol., 10, 2003
|
|
2BJ0
 | | Crystal Structure of AChBP from Bulinus truncatus revals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors | | 分子名称: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ACETYLCHOLINE-BINDING PROTEIN | | 著者 | Celie, P.H.N, Klaassen, R.V, Van Rossum-Fikkert, S.E, Van Elk, R, Van Nierop, P, Smit, A.B, Sixma, T.K. | | 登録日 | 2005-01-27 | | 公開日 | 2005-05-24 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of Acetylcholine-Binding Protein from Bulinus Truncatus Reveals the Conserved Structural Scaffold and Sites of Variation in Nicotinic Acetylcholine Receptors.
J.Biol.Chem., 280, 2005
|
|
5V9U
 | | Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C | | 分子名称: | (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | | 著者 | Janes, M.R, Zhang, J, Li, L.-S, Hansen, R, Peters, U, Guo, X, Chen, Y, Babbar, A, Firdaus, S.J, Feng, J, Chen, J.H, Li, S, Brehmer, D, Darjania, L, Li, S, Long, Y.O, Thach, C, Liu, Y, Zarieh, A, Ely, T, Kucharski, J.M, Kessler, L.V, Wu, T, Wang, Y, Yao, Y, Deng, X, Zarrinkar, P, Dashyant, D, Lorenzi, M.V, Hu-Lowe, D, Patricelli, M.P, Ren, P, Liu, Y. | | 登録日 | 2017-03-23 | | 公開日 | 2018-02-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
|
|
3E2D
 | | The 1.4 A crystal structure of the large and cold-active Vibrio sp. alkaline phosphatase | | 分子名称: | 1,2-ETHANEDIOL, Alkaline phosphatase, MAGNESIUM ION, ... | | 著者 | Helland, R, Larsen, R.L, Asgeirsson, B. | | 登録日 | 2008-08-05 | | 公開日 | 2009-06-16 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The 1.4 A crystal structure of the large and cold-active Vibrio sp. alkaline phosphatase.
Biochim.Biophys.Acta, 1794, 2009
|
|
2PC0
 | | Apo Wild-type HIV Protease in the open conformation | | 分子名称: | MAGNESIUM ION, Protease, R-1,2-PROPANEDIOL | | 著者 | Heaslet, H, Rosenfeld, R, Giffin, M.J, Elder, J.H, McRee, D.E, Stout, C.D. | | 登録日 | 2007-03-29 | | 公開日 | 2007-06-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Conformational flexibility in the flap domains of ligand-free HIV protease.
Acta Crystallogr.,Sect.D, 63, 2007
|
|
2V8O
 | | Structure of the Murray Valley encephalitis virus RNA helicase to 1. 9A resolution | | 分子名称: | FLAVIVIRIN PROTEASE NS3 | | 著者 | Mancini, E.J, Assenberg, R, Verma, A, Walter, T.S, Tuma, R, Grimes, J.M, Owens, R.J, Stuart, D.I. | | 登録日 | 2007-08-09 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of the Murray Valley Encephalitis Virus RNA Helicase at 1.9 A Resolution.
Protein Sci., 16, 2007
|
|
2CKJ
 | | Human milk xanthine oxidoreductase | | 分子名称: | ACETIC ACID, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Pearson, A.R, Godber, B.L.J, Eisenthal, R, Taylor, G.L, Harrison, R. | | 登録日 | 2006-04-19 | | 公開日 | 2007-05-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | | 主引用文献 | Human Milk Xanthine Dehydrogenase is Incompletely Converted to the Oxidase Form in the Absence of Proteolysis. A Structural Explanation.
To be Published
|
|
1F3W
 | | RECOMBINANT RABBIT MUSCLE PYRUVATE KINASE | | 分子名称: | MANGANESE (II) ION, POTASSIUM ION, PYRUVATE KINASE, ... | | 著者 | Wooll, J.O, Friesen, R.H.E, White, M.A, Watowich, S.J, Fox, R.O, Lee, J.C, Czerwinski, E.W. | | 登録日 | 2000-06-06 | | 公開日 | 2001-10-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase.
J.Mol.Biol., 312, 2001
|
|
1F3X
 | | S402P MUTANT OF RABBIT MUSCLE PYRUVATE KINASE | | 分子名称: | MANGANESE (II) ION, POTASSIUM ION, PYRUVATE KINASE, ... | | 著者 | Wooll, J.O, Friesen, R.H.E, White, M.A, Watowich, S.J, Fox, R.O, Lee, J.C, Czerwinski, E.W. | | 登録日 | 2000-06-06 | | 公開日 | 2001-10-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase.
J.Mol.Biol., 312, 2001
|
|
1OB5
 | | T. aquaticus elongation factor EF-Tu complexed with the antibiotic enacyloxin IIa, a GTP analog, and Phe-tRNA | | 分子名称: | ELONGATION FACTOR TU, ENACYLOXIN IIA, MAGNESIUM ION, ... | | 著者 | Dahlberg, C, Nielsen, R.C, Parmeggiani, A, Nyborg, J, Nissen, P. | | 登録日 | 2003-01-24 | | 公開日 | 2005-10-13 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Enacyloxin Iia Pinpoints a Binding Pocket of Elongation Factor TU for Development of Novel Antibiotics.
J.Biol.Chem., 281, 2006
|
|
1ZVD
 | | Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain | | 分子名称: | PHOSPHATE ION, SODIUM ION, Smad ubiquitination regulatory factor 2 | | 著者 | Ogunjimi, A.A, Briant, D.J, Pece-Barbara, N, Le Roy, C, Di Guglielmo, G.M, Kavsak, P, Rasmussen, R.K, Seet, B.T, Sicheri, F, Wrana, J.L. | | 登録日 | 2005-06-01 | | 公開日 | 2005-08-09 | | 最終更新日 | 2011-09-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain.
Mol.Cell, 19, 2005
|
|
1QOM
 | | MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH SWAPPED N-TERMINAL HOOK | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Crane, B.R, Rosenfeld, R.A, Arvai, A.S, Tainer, J.A, Stuehr, D.J, Getzoff, E.D. | | 登録日 | 1999-11-15 | | 公開日 | 1999-12-15 | | 最終更新日 | 2019-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | N-Terminal Domain Swapping and Metal Ion Binding in Nitric Oxide Synthase Dimerization
Embo J., 18, 1999
|
|
1I9B
 | | X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETYLCHOLINE BINDING PROTEIN, CALCIUM ION | | 著者 | Brejc, K, van Dijk, W.J, Klaassen, R, Schuurmans, M, van der Oost, J, Smit, A.B, Sixma, T.K. | | 登録日 | 2001-03-18 | | 公開日 | 2001-05-16 | | 最終更新日 | 2018-03-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.
Nature, 411, 2001
|
|
2BCD
 | | X-ray crystal structure of Protein Phosphatase-1 with the marine toxin motuporin bound | | 分子名称: | BETA-MERCAPTOETHANOL, MANGANESE (II) ION, MOTUPORIN, ... | | 著者 | Maynes, J.T, Luu, H.A, Cherney, M.M, Andersen, R.J, Williams, D, Holmes, C.F, James, M.N. | | 登録日 | 2005-10-19 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structures of Protein Phosphatase-1 Bound to Motuporin and Dihydromicrocystin-LA: Elucidation of the Mechanism of Enzyme Inhibition by Cyanobacterial Toxins.
J.Mol.Biol., 356, 2006
|
|
3IOI
 | | Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (1GW) | | 分子名称: | 5-(2-FORMYLTHIEN-5-YL)-URIDINE-5'-DIPHOSPHATE-ALPHA-D-GALACTOSE, Histo-blood group ABO system transferase, MANGANESE (II) ION, ... | | 著者 | Pesnot, T, Jorgensen, R, Palcic, M.M, Wagner, G.K. | | 登録日 | 2009-08-14 | | 公開日 | 2010-04-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structural and mechanistic basis for a new mode of glycosyltransferase inhibition.
Nat.Chem.Biol., 6, 2010
|
|
2BDX
 | | X-ray Crystal Structure of dihydromicrocystin-LA bound to Protein Phosphatase-1 | | 分子名称: | DIHYDROMICROCYSTIN-LA, MANGANESE (II) ION, Serine/threonine protein phosphatase PP1-gamma catalytic subunit | | 著者 | Maynes, J.T, Luu, H.A, Cherney, M.M, Andersen, R.J, Williams, D, Holmes, C.F, James, M.N. | | 登録日 | 2005-10-21 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structures of Protein Phosphatase-1 Bound to Motuporin and Dihydromicrocystin-LA: Elucidation of the Mechanism of Enzyme Inhibition by Cyanobacterial Toxins.
J.Mol.Biol., 356, 2006
|
|
3IOH
 | | Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) | | 分子名称: | GLYCEROL, Histo-blood group ABO system transferase | | 著者 | Pesnot, T, Jorgensen, R, Palcic, M.M, Wagner, G.K. | | 登録日 | 2009-08-14 | | 公開日 | 2010-04-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structural and mechanistic basis for a new mode of glycosyltransferase inhibition.
Nat.Chem.Biol., 6, 2010
|
|
3E7I
 | | Structure of murine inos oxygenase domain with inhibitor AR-C94864 | | 分子名称: | (2R)-5-FLUORO-2-(2-THIENYL)-1,2-DIHYDROQUINAZOLIN-4-AMINE, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... | | 著者 | Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stuehr, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. | | 登録日 | 2008-08-18 | | 公開日 | 2008-10-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4, 2008
|
|
