3IOH

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A)

Summary for 3IOH

Entry DOI	10.2210/pdb3ioh/pdb
Related	1LZ0 3IOI 3IOJ
Descriptor	Histo-blood group ABO system transferase, GLYCEROL (3 entities in total)
Functional Keywords	gta, abo, cisab mutant, aa(gly)b, rossmann fold, unliganded, open conformation, blood group antigen, glycoprotein, glycosyltransferase, golgi apparatus, manganese, membrane, metal-binding, polymorphism, secreted, signal-anchor, transferase, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
Total number of polymer chains	1
Total formula weight	34746.10
Authors	Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. (deposition date: 2009-08-14, release date: 2010-04-07, Last modification date: 2023-09-06)
Primary citation	Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. Structural and mechanistic basis for a new mode of glycosyltransferase inhibition. Nat.Chem.Biol., 6:321-323, 2010 Cited by PubMed: 20364127 DOI: 10.1038/nchembio.343 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation