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3IOI

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (1GW)

Summary for 3IOI
Entry DOI10.2210/pdb3ioi/pdb
Related1LZ0 3IOH 3IOJ
DescriptorHisto-blood group ABO system transferase, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total)
Functional Keywordsgta, abo, cisab mutant, aa(gly)b, rossmann fold, inhibitor, semi-closed conformation, blood group antigen, glycoprotein, glycosyltransferase, golgi apparatus, manganese, membrane, metal-binding, polymorphism, secreted, signal-anchor, transferase, transmembrane
Biological sourceHomo sapiens (human)
Cellular locationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
Total number of polymer chains1
Total formula weight35481.45
Authors
Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. (deposition date: 2009-08-14, release date: 2010-04-07, Last modification date: 2023-09-06)
Primary citationPesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K.
Structural and mechanistic basis for a new mode of glycosyltransferase inhibition.
Nat.Chem.Biol., 6:321-323, 2010
Cited by
PubMed: 20364127
DOI: 10.1038/nchembio.343
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.45 Å)
Structure validation

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