2C36

Structure of unliganded HSV gD reveals a mechanism for receptor- mediated activation of virus entry

Summary for 2C36

• Entry DOI: 10.2210/pdb2c36/pdb
• Related: 1JMA 1L2G 2C3A
• Descriptor: GLYCOPROTEIN D HSV-1, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: virus, viral protein, herpes, immunoglobulin-like, glycoprotein, transmembrane
• Biological source: HUMAN HERPESVIRUS 1 (HERPES SIMPLEX VIRUS (HSV-1, HUMAN))
• Total number of polymer chains: 2
• Total formula weight: 65049.04

Authors

Krummenacher, C.,Supekar, V.M.,Whitbeck, J.C.,Lazear, E.,Connolly, S.A.,Eisenberg, R.J.,Cohen, G.H.,Wiley, D.C.,Carfi, A. (deposition date: 2005-10-04, release date: 2005-11-23, Last modification date: 2023-12-13)

• Primary citation: Krummenacher, C.,Supekar, V.M.,Whitbeck, J.C.,Lazear, E.,Connolly, S.A.,Eisenberg, R.J.,Cohen, G.H.,Wiley, D.C.,Carfi, A.; Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry.; EMBO J., 24:4144-4153, 2005; PubMed: 16292345; DOI: 10.1038/sj.emboj.7600875

Experimental method

X-RAY DIFFRACTION (2.11 Å)