8GJ4
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8GLC
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8U3N
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8P4Z
| Crystal structure of the human CDK7 kinase domain in complex with LDC4297 | 分子名称: | 2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine, Cyclin-dependent kinase 7, GLYCEROL, ... | 著者 | Laursen, M, Caing-Carlsson, R, Houssari, R, Javadi, A, Kimbung, Y.R, Murina, V, Orozco-Rodriguez, J.M, Svensson, A, Welin, M, Logan, D, Svensson, B, Walse, B. | 登録日 | 2023-05-23 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of the human CDK7 kinase domain in complex with LDC4297 To Be Published
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4XCP
| Fatty Acid and Retinol binding protein Na-FAR-1 from Necator americanus | 分子名称: | Nematode fatty acid retinoid binding protein, PALMITIC ACID | 著者 | Gabrielsen, M, Rey-Burusco, M.F, Ibanez-Shimabukuro, M, Griffiths, K, Kennedy, M.W, Corsico, B, Smith, B.O. | 登録日 | 2014-12-18 | 公開日 | 2015-09-16 | 最終更新日 | 2017-08-30 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus. Biochem.J., 471, 2015
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6FAO
| Discovery and characterization of a thermostable GH6 endoglucanase from a compost metagenome | 分子名称: | 1,2-ETHANEDIOL, Glycoside hydrolase family 6, SULFATE ION | 著者 | Jensen, M.S, Fredriksen, L, MacKenzie, A.K, Pope, P.B, Chylenski, P, Leiros, I, Williamson, A.K, Christopeit, T, Ostby, H, Vaaje-Kolstad, G, Eijsink, V.G.H. | 登録日 | 2017-12-15 | 公開日 | 2018-06-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Discovery and characterization of a thermostable two-domain GH6 endoglucanase from a compost metagenome. PLoS ONE, 13, 2018
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8RP8
| Structure of K2 Fab in complex with human CD47 ECD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Laursen, M, Kelpsas, V, Rose, N. | 登録日 | 2024-01-12 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1. Mabs, 16, 2024
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8PVS
| Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood | 分子名称: | 1,2-ETHANEDIOL, Alpha-1,3-galactosidase B, CALCIUM ION, ... | 著者 | Jensen, M, Abou Hachem, M, Morth, J.P. | 登録日 | 2023-07-18 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood. Nat Microbiol, 9, 2024
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8PXU
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8PXT
| Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood | 分子名称: | 2-acetamido-2-deoxy-beta-D-galactopyranose, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | 著者 | Jensen, M, Abou Hachem, M, Morth, J.P. | 登録日 | 2023-07-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood. Nat Microbiol, 9, 2024
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6GW6
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6XYG
| Femtosecond structure of bovine trypsin at room temperature | 分子名称: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | 著者 | Jensen, M. | 登録日 | 2020-01-30 | 公開日 | 2021-02-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.50000238 Å) | 主引用文献 | High-resolution macromolecular crystallography at the FemtoMAX beamline with time-over-threshold photon detection J.Synchrotron Radiat., 2021
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7SFL
| Human NKCC1 state Fu-II | 分子名称: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | 著者 | Moseng, M.A. | 登録日 | 2021-10-04 | 公開日 | 2022-09-28 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. Sci Adv, 8, 2022
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4XQ7
| The crystal structure of the OAS-like domain (OLD) of human OASL | 分子名称: | 2'-5'-oligoadenylate synthase-like protein | 著者 | Ibsen, M.S, Gad, H.H, Andersen, L.L, Hornung, V, Julkunen, I, Sarkar, S.N, Hartmann, R. | 登録日 | 2015-01-19 | 公開日 | 2015-04-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling. Nucleic Acids Res., 43, 2015
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6P17
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7T7I
| EBV nuclear egress complex | 分子名称: | Nuclear egress protein 1, Nuclear egress protein 2, ZINC ION | 著者 | Thorsen, M.K, Heldwein, E.E. | 登録日 | 2021-12-15 | 公開日 | 2022-07-06 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.97 Å) | 主引用文献 | The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. Plos Pathog., 18, 2022
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6P16
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7SMP
| CryoEM structure of NKCC1 Bu-I | 分子名称: | 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, POTASSIUM ION, Solute carrier family 12 member 2 | 著者 | Moseng, M.A. | 登録日 | 2021-10-26 | 公開日 | 2022-09-28 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. Sci Adv, 8, 2022
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5X94
| Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex | 分子名称: | Cag pathogenicity island protein, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Senda, M, Senda, T. | 登録日 | 2017-03-05 | 公開日 | 2017-09-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Rep, 20, 2017
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8P1W
| Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with allosteric compound STL232591 | 分子名称: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, 8-methoxy-1-(4-methoxyphenyl)-3-methyl-2-oxidanyl-[1]benzofuro[3,2-c]pyridine, ... | 著者 | Thomsen, M, Thieulin-Pardo, G, Neumann, L. | 登録日 | 2023-05-12 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94, 2023
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8P4H
| Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound IDEAYA cmpd A | 分子名称: | 7-chloranyl-4-[(3R)-3-fluoranylpyrrolidin-1-yl]-1-phenyl-quinazolin-2-one, CHLORIDE ION, GLYCEROL, ... | 著者 | Thomsen, M, Thieulin-Pardo, G, Neumann, L. | 登録日 | 2023-05-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94, 2023
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7GQT
| Crystal Structure of Werner helicase fragment 517-945 in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, MAGNESIUM ION, ... | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | 登録日 | 2023-10-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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7GQS
| Crystal Structure of Werner helicase fragment 517-945 in complex with ADP | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ... | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | 登録日 | 2023-10-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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7GQU
| Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, GLYCEROL, ... | 著者 | Classen, M, Benz, J, Brugger, D, Tagliente, O, Rudolph, M.G. | 登録日 | 2023-10-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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5X7B
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