8GLC

A1 AncAla: Adenylation domain 1 core construct from ancestral reconstruction of glycopeptide antibiotic biosynthesis, alanine selection pocket

Summary for 8GLC

Entry DOI	10.2210/pdb8glc/pdb
Descriptor	Non-ribosomal peptide synthetase, MbtH-like short polypeptide (2 entities in total)
Functional Keywords	amp-binding enzyme, nrps, adenylation domain, ligase
Biological source	Actinoplanes More
Total number of polymer chains	4
Total formula weight	100599.50
Authors	Hansen, M.H.,Cryle, M.J. (deposition date: 2023-03-21, release date: 2023-12-06, Last modification date: 2023-12-13)
Primary citation	Hansen, M.H.,Adamek, M.,Iftime, D.,Petras, D.,Schuseil, F.,Grond, S.,Stegmann, E.,Cryle, M.J.,Ziemert, N. Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides. Nat Commun, 14:7842-7842, 2023 Cited by PubMed: 38030603 DOI: 10.1038/s41467-023-43451-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.12 Å)

Structure validation