8P4Z

Crystal structure of the human CDK7 kinase domain in complex with LDC4297

Summary for 8P4Z

• Entry DOI: 10.2210/pdb8p4z/pdb
• Descriptor: Cyclin-dependent kinase 7, 2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine, GLYCEROL, ... (6 entities in total)
• Functional Keywords: transferase, cyclin-dependent kinase, cell division, cell cycle
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 70737.70

Authors

Laursen, M.,Caing-Carlsson, R.,Houssari, R.,Javadi, A.,Kimbung, Y.R.,Murina, V.,Orozco-Rodriguez, J.M.,Svensson, A.,Welin, M.,Logan, D.,Svensson, B.,Walse, B. (deposition date: 2023-05-23, release date: 2023-06-14, Last modification date: 2024-02-07)

• Primary citation: Laursen, M.,Caing-Carlsson, R.,Houssari, R.,Javadi, A.,Kimbung, Y.R.,Murina, V.,Orozco-Rodriguez, J.M.,Svensson, A.,Welin, M.,Logan, D.,Svensson, B.,Walse, B.; Crystal structure of the human CDK7 kinase domain in complex with LDC4297; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)