8P4Z
Crystal structure of the human CDK7 kinase domain in complex with LDC4297
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Cyclin-dependent kinase 7 | polymer | 304 | 34373.7 | 2 | UniProt (P50613) Pfam (PF00069) In PDB | Homo sapiens (human) | 39 kDa protein kinase,p39 Mo15,CDK-activating kinase 1,Cell division protein kinase 7,Serine/threonine-protein kinase 1,TFIIH basal transcription factor complex kinase subunit |
| 2 | A, B | 2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine | non-polymer | 432.5 | 2 | Chemie (WZ8) | |||
| 3 | A, B | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 4 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 5 | B | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 6 | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A, B: 10 - 311 (UniProt: P50613)
| PDB | External Database | Details |
|---|---|---|
| Gly 8 | - | expression tag |
| Pro 9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68747.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1990.2 | |
| All* | Total formula weight | 70737.7 |
