8P4Z
Crystal structure of the human CDK7 kinase domain in complex with LDC4297
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005675 | cellular_component | transcription factor TFIIH holo complex |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0008353 | molecular_function | RNA polymerase II CTD heptapeptide repeat kinase activity |
| A | 0070985 | cellular_component | transcription factor TFIIK complex |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005675 | cellular_component | transcription factor TFIIH holo complex |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0008353 | molecular_function | RNA polymerase II CTD heptapeptide repeat kinase activity |
| B | 0070985 | cellular_component | transcription factor TFIIK complex |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK |
| Chain | Residue | Details |
| A | LEU18-LYS42 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL |
| Chain | Residue | Details |
| A | ILE133-LEU145 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
