8P4Z
Crystal structure of the human CDK7 kinase domain in complex with LDC4297
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005675 | cellular_component | transcription factor TFIIH holo complex |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0008353 | molecular_function | RNA polymerase II CTD heptapeptide repeat kinase activity |
| A | 0070985 | cellular_component | transcription factor TFIIK complex |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005675 | cellular_component | transcription factor TFIIH holo complex |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0008353 | molecular_function | RNA polymerase II CTD heptapeptide repeat kinase activity |
| B | 0070985 | cellular_component | transcription factor TFIIK complex |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK |
| Chain | Residue | Details |
| A | LEU18-LYS42 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL |
| Chain | Residue | Details |
| A | ILE133-LEU145 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:15530371 |
| Chain | Residue | Details |
| A | ASP137 | |
| B | ASP137 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:15530371 |
| Chain | Residue | Details |
| A | LEU18 | |
| A | LYS41 | |
| B | LEU18 | |
| B | LYS41 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CDK1 and CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER164 | |
| B | SER164 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:15530371, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR170 | |
| B | THR170 |
