7SFL

Human NKCC1 state Fu-II

Summary for 7SFL

• Entry DOI: 10.2210/pdb7sfl/pdb
• EMDB information: 25092
• Descriptor: Solute carrier family 12 member 2, 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID (2 entities in total)
• Functional Keywords: furosemide, loop diuretic, diuretic, sodium, potassium, chloride, co-transporter, ctd, nkcc1, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 201532.88

Authors

Moseng, M.A. (deposition date: 2021-10-04, release date: 2022-09-28, Last modification date: 2023-05-31)

• Primary citation: Moseng, M.A.,Su, C.C.,Rios, K.,Cui, M.,Lyu, M.,Glaza, P.,Klenotic, P.A.,Delpire, E.,Yu, E.W.; Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.; Sci Adv, 8:eabq0952-eabq0952, 2022; PubMed: 36306358; DOI: 10.1126/sciadv.abq0952

Experimental method

ELECTRON MICROSCOPY (3.87 Å)