7SFL
Human NKCC1 state Fu-II
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
A | 0016020 | cellular_component | membrane |
A | 0022857 | molecular_function | transmembrane transporter activity |
A | 0055085 | biological_process | transmembrane transport |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
B | 0016020 | cellular_component | membrane |
B | 0022857 | molecular_function | transmembrane transporter activity |
B | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 92 |
Details | TRANSMEM: Discontinuously helical => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714 |
Chain | Residue | Details |
A | TRP287-GLY313 | |
A | PHE487-ILE507 | |
B | TRP287-GLY313 | |
B | PHE487-ILE507 |
site_id | SWS_FT_FI2 |
Number of Residues | 68 |
Details | INTRAMEM: Helical => ECO:0000305|PubMed:32081947 |
Chain | Residue | Details |
A | TRP287-ILE299 | |
A | LEU308-GLY313 | |
A | PHE487-ALA498 | |
A | ILE501-ILE507 | |
B | TRP287-ILE299 | |
B | LEU308-GLY313 | |
B | PHE487-ALA498 | |
B | ILE501-ILE507 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | INTRAMEM: INTRAMEM => ECO:0000305|PubMed:32081947 |
Chain | Residue | Details |
A | TRP300-ARG307 | |
A | THR499-GLY500 | |
B | TRP300-ARG307 | |
B | THR499-GLY500 |
site_id | SWS_FT_FI4 |
Number of Residues | 208 |
Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714 |
Chain | Residue | Details |
A | GLN314-VAL321 | |
B | CYS543-PHE599 | |
B | ALA669-GLU670 | |
B | ASN731 | |
A | HIS398-ILE406 | |
A | ILE455-THR486 | |
A | CYS543-PHE599 | |
A | ALA669-GLU670 | |
A | ASN731 | |
B | GLN314-VAL321 | |
B | HIS398-ILE406 | |
B | ILE455-THR486 |
site_id | SWS_FT_FI5 |
Number of Residues | 466 |
Details | TRANSMEM: Helical => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714 |
Chain | Residue | Details |
A | LEU322-THR343 | |
A | TRP732-TYR751 | |
B | LEU322-THR343 | |
B | PRO362-GLU397 | |
B | ASN407-SER424 | |
B | TRP430-PHE454 | |
B | GLN515-SER542 | |
B | THR600-ASP632 | |
B | GLY654-ILE668 | |
B | LEU671-SER697 | |
B | ASN712-ILE730 | |
A | PRO362-GLU397 | |
B | TRP732-TYR751 | |
A | ASN407-SER424 | |
A | TRP430-PHE454 | |
A | GLN515-SER542 | |
A | THR600-ASP632 | |
A | GLY654-ILE668 | |
A | LEU671-SER697 | |
A | ASN712-ILE730 |
site_id | SWS_FT_FI6 |
Number of Residues | 120 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714 |
Chain | Residue | Details |
A | ASN344-GLY361 | |
B | LEU698-TYR711 | |
A | VAL425-GLU429 | |
A | SER508-PRO514 | |
A | ASN633-ARG653 | |
A | LEU698-TYR711 | |
B | ASN344-GLY361 | |
B | VAL425-GLU429 | |
B | SER508-PRO514 | |
B | ASN633-ARG653 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | UNK940 | |
A | UNK994 | |
B | UNK940 | |
B | UNK994 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55012 |
Chain | Residue | Details |
A | UNK944 | |
B | UNK944 |