2HVX
 
 | | Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase by Using Structure-Based Drug Design | | Descriptor: | Chymase, [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID | | Authors: | Greco, M.N, Hawkins, M.J, Powell, E.T, Almond, H.R, de Garavilla, L, Wang, Y, Minor, L.A, Wells, G.I, Di Cera, E, Cantwell, A.M, Savvides, S.N, Damiano, B.P, Maryanoff, B.E. | | Deposit date: | 2006-07-31 | | Release date: | 2007-06-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
J.Med.Chem., 50, 2007
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6GLX
 | | Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 4E8 | | Descriptor: | Fab 4E8 - Heavy chain, Fab 4E8 - Light chain, Galectin-10 | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-23 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.396 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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5N7L
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6GKU
 | | Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 6F5 | | Descriptor: | CALCIUM ION, Fab 6F5 - Heavy Chain, Fab 6F5 - Light chain, ... | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-21 | | Release date: | 2019-06-05 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GLW
 | | Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 1D11 | | Descriptor: | ACETATE ION, Fab 1D11 - Heavy chain, Fab 1D11 - Light chain, ... | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-23 | | Release date: | 2019-06-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GKS
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6GKQ
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3TPA
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3UF2
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8ODZ
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-03-10 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8OE0
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-03-10 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8OE4
 | | Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | | Authors: | Bloch, Y, Felix, J, Savvides, S.N. | | Deposit date: | 2023-03-10 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8PB1
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-06-08 | | Release date: | 2024-02-07 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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4C0R
 | | Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans. | | Descriptor: | CADMIUM ION, CHLORIDE ION, OXIDIZED GLUTATHIONE DISULFIDE, ... | | Authors: | Vergauwen, B, Verstraete, K, Senadheera, D.B, Dansercoer, A, Cvitkovitch, D.G, Guedon, E, Savvides, S.N. | | Deposit date: | 2013-08-07 | | Release date: | 2013-08-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.547 Å) | | Cite: | Molecular and Structural Basis of Glutathione Import in Gram-Positive Bacteria Via Gsht and the Cystine Abc Importer Tcybc of Streptococcus Mutans.
Mol.Microbiol., 89, 2013
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8OYE
 | | Clostridium perfringens chitinase CP4_3455 E196Q with chitin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitodextrinase, DIMETHYL SULFOXIDE | | Authors: | Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-05-04 | | Release date: | 2023-07-12 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Clostridium perfringens chitinase CP4_3455 E196Q with chitin
To Be Published
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8OSE
 | | C. perfringens chitinase CP4_3455 in complex with inhibitor bisdionin C | | Descriptor: | 1,1'-PROPANE-1,3-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE), 1,2-ETHANEDIOL, Chitodextrinase, ... | | Authors: | Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-04-18 | | Release date: | 2023-07-12 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | C. perfringens chitinase CP4_3455 in complex with inhibitor bisdionin C
To Be Published
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8QMG
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4ADF
 | | CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (hCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1 | | Descriptor: | MACROPHAGE COLONY-STIMULATING FACTOR 1, SECRETED PROTEIN BARF1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Elegheert, J, Bracke, N, Savvides, S.N. | | Deposit date: | 2011-12-23 | | Release date: | 2012-08-22 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (4.4 Å) | | Cite: | Allosteric Competitive Inactivation of Hematopoietic Csf-1 Signaling by the Viral Decoy Receptor Barf1.
Nat.Struct.Mol.Biol., 19, 2012
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6GKT
 | | X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu | | Descriptor: | Galectin-10, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-21 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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3RRS
 | | Crystal structure analysis of cellobiose phosphorylase from Cellulomonas uda | | Descriptor: | Cellobiose phosphorylase | | Authors: | Van Hoorebeke, A, Stout, J, Soetaert, W, Van Beeumen, J, Desmet, T, Savvides, S. | | Deposit date: | 2011-04-30 | | Release date: | 2012-05-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Cellobiose phosphorylase: reconstructing the structural itinerary along the catalytic pathway
To be Published
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3DJG
 | | Catalytic cycle of human glutathione reductase near 1 A resolution | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A. | | Deposit date: | 2008-06-23 | | Release date: | 2008-08-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Catalytic cycle of human glutathione reductase near 1 A resolution.
J.Mol.Biol., 382, 2008
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1GSN
 | | HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DINITROSOGLUTATHIONE | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLUTATHIONE REDUCTASE, ... | | Authors: | Becker, K, Savvides, S.N, Keese, M, Schirmer, R.H, Karplus, P.A. | | Deposit date: | 1998-02-21 | | Release date: | 1998-05-27 | | Last modified: | 2011-12-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.
Nat.Struct.Biol., 5, 1998
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3S4A
 | | Cellobiose phosphorylase from Cellulomonas uda in complex with cellobiose | | Descriptor: | Cellobiose phosphorylase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | | Authors: | Van Hoorebeke, A, Stout, J, Soetaert, W, Van Beeumen, J, Desmet, T, Savvides, S. | | Deposit date: | 2011-05-19 | | Release date: | 2012-06-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Cellobiose phosphorylase: reconstructing the structural itinerary along the catalytic pathway
To be Published
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1DNC
 | | HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLUTATHIONE REDUCTASE, ... | | Authors: | Becker, K, Savvides, S.N, Keese, M, Schirmer, R.H, Karplus, P.A. | | Deposit date: | 1998-02-20 | | Release date: | 1998-05-27 | | Last modified: | 2011-12-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.
Nat.Struct.Biol., 5, 1998
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3S4B
 | | Cellobiose phosphorylase from Cellulomonas uda in complex with glucose | | Descriptor: | Cellobiose phosphorylase, alpha-D-glucopyranose | | Authors: | Van Hoorebeke, A, Stout, J, Soetaert, W, Van Beeumen, J, Desmet, T, Savvides, S. | | Deposit date: | 2011-05-19 | | Release date: | 2012-06-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Cellobiose phosphorylase: reconstructing the structural itinerary along the catalytic pathway
To be Published
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