3UF2

Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine

Summary for 3UF2

Entry DOI	10.2210/pdb3uf2/pdb
Related	1HMC 3UEZ 3UF5
Descriptor	Macrophage colony-stimulating factor 1 (2 entities in total)
Functional Keywords	hematopoietic cytokine, rtkiii, four-helix bundle, cytokine
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass membrane protein. Processed macrophage colony-stimulating factor 1: Secreted, extracellular space: P09603
Total number of polymer chains	10
Total formula weight	178682.19
Authors	Elegheert, J.,Savvides, S.N. (deposition date: 2011-10-31, release date: 2012-08-22, Last modification date: 2013-07-17)
Primary citation	Elegheert, J.,Bracke, N.,Pouliot, P.,Gutsche, I.,Shkumatov, A.V.,Tarbouriech, N.,Verstraete, K.,Bekaert, A.,Burmeister, W.P.,Svergun, D.I.,Lambrecht, B.N.,Vergauwen, B.,Savvides, S.N. Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1 Nat.Struct.Mol.Biol., 19:938-947, 2012 Cited by PubMed: 22902366 DOI: 10.1038/nsmb.2367 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation