Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 424 results
4R67
DownloadVisualize
BU of 4r67 by Molmil
Human constitutive 20S proteasome in complex with carfilzomib
Descriptor: N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ...
Authors:Sacchettini, J.C, Harshbarger, W.H.
Deposit date:2014-08-22
Release date:2015-02-11
Last modified:2015-02-18
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib.
Structure, 23, 2015
4XT8
DownloadVisualize
BU of 4xt8 by Molmil
Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimetrexate
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-23
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT7
DownloadVisualize
BU of 4xt7 by Molmil
Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimethoprim
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-23
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT6
DownloadVisualize
BU of 4xt6 by Molmil
Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with the tetrahydropteridine ring of tetrahydrofolate (THF)
Descriptor: (6S)-2-amino-6-methyl-5,6,7,8-tetrahydropteridin-4(3H)-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Rv2671
Authors:Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-23
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT5
DownloadVisualize
BU of 4xt5 by Molmil
Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Rv2671
Authors:Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-22
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT4
DownloadVisualize
BU of 4xt4 by Molmil
Crystal structure of Rv2671 from Mycobacteirum tuberculosis in complex with dihydropteridine ring of dihydropteroic acid
Descriptor: 2-amino-6-methyl-7,8-dihydropteridin-4(3H)-one, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-22
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.891 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4R3O
DownloadVisualize
BU of 4r3o by Molmil
Human Constitutive 20S Proteasome
Descriptor: Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ...
Authors:Sacchettini, J.C, Harshbarger, W.H.
Deposit date:2014-08-16
Release date:2015-01-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib.
Structure, 23, 2015
2IFB
DownloadVisualize
BU of 2ifb by Molmil
CRYSTAL STRUCTURE OF RAT INTESTINAL FATTY-ACID-BINDING PROTEIN. REFINEMENT AND ANALYSIS OF THE ESCHERICHIA COLI-DRIVED PROTEIN WITH BOUND PALMITATE
Descriptor: INTESTINAL FATTY ACID BINDING PROTEIN, PALMITIC ACID
Authors:Sacchettini, J.C, Gordon, J.I, Banaszak, L.J.
Deposit date:1990-12-05
Release date:1992-01-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.
J.Mol.Biol., 208, 1989
1IFB
DownloadVisualize
BU of 1ifb by Molmil
REFINED APOPROTEIN STRUCTURE OF RAT INTESTINAL FATTY ACID BINDING PROTEIN PRODUCED IN ESCHERICHIA COLI
Descriptor: INTESTINAL FATTY ACID BINDING PROTEIN
Authors:Sacchettini, J.C, Gordon, J.I, Banaszak, L.J.
Deposit date:1990-12-05
Release date:1992-01-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli.
Proc.Natl.Acad.Sci.USA, 86, 1989
3F4B
DownloadVisualize
BU of 3f4b by Molmil
Crystal structure of Plasmodium berghei Enoyl-acyl-carrier-protein reductase with TRICLOSAN
Descriptor: Enoyl-acyl carrier protein reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Sacchettini, J.C, Tsai, H.-C.
Deposit date:2008-10-31
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Cell Host Microbe, 4, 2008
2HH7
DownloadVisualize
BU of 2hh7 by Molmil
Crystal Structure of Cu(I) bound CsoR from Mycobacterium tuberculosis.
Descriptor: COPPER (I) ION, Hypothetical protein CsoR
Authors:Sacchettini, J.C, Ramesh, A.
Deposit date:2006-06-27
Release date:2006-12-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
Nat.Chem.Biol., 3, 2007
3OKR
DownloadVisualize
BU of 3okr by Molmil
Structure of Mtb apo 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD)
Descriptor: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, Heptamer peptide
Authors:Sacchettini, J.C, Reddy, M.C.M, Bruning, J.B, Thurman, C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-08-25
Release date:2010-10-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): an antitubercular drug target
To be Published
1M1M
DownloadVisualize
BU of 1m1m by Molmil
X-RAY CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (MTFABH)
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III
Authors:Sacchettini, J.C, Sridharan, S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-06-19
Release date:2002-07-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
J.Biol.Chem., 280, 2005
4UBE
DownloadVisualize
BU of 4ube by Molmil
CRYSTAL STRUCTURE OF M TUBERCULOSIS ADENOSINE KINASE COMPLEXED WITH 2-FLURO ADENOSINE
Descriptor: 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, Adenosine kinase
Authors:Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C.
Deposit date:2014-08-12
Release date:2014-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.933 Å)
Cite:CRYSTAL STRUCTURE OF M TUBERCULOSIS ADENOSINE KINASE COMPLEXED WITH 2-FLURO ADENOSINE
TO BE PUBLISHED
8GKF
DownloadVisualize
BU of 8gkf by Molmil
Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.
Descriptor: 4'-phosphopantetheinyl transferase PptT, TOMUDEX
Authors:Krieger, I.V, Singh, A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2023-03-18
Release date:2024-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.
Sci Adv, 10, 2024
4UAQ
DownloadVisualize
BU of 4uaq by Molmil
Crystal structure of the accessory translocation ATPase, SecA2, from Mycobacterium tuberculosis
Descriptor: Protein translocase subunit SecA 2
Authors:Swanson-Smith, S, Ioerger, T.R, Rigel, N.W, Miller, B.K, Braunstein, M, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-08-11
Release date:2015-09-09
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
J.Bacteriol., 198, 2015
6WSI
DownloadVisualize
BU of 6wsi by Molmil
Intact cis-2,3-epoxysuccinic acid bound to Isocitrate Lyase-1 from Mycobacterium tuberculosis
Descriptor: (2R,3S)-oxirane-2,3-dicarboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Krieger, I.V, Mellott, D, Meek, T.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2020-05-01
Release date:2021-03-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis -2,3-Epoxy-Succinic Acid.
Acs Chem.Biol., 16, 2021
6MJ1
DownloadVisualize
BU of 6mj1 by Molmil
Crystal structure of RefZ (regulator of FtsZ) from Bacillus subtilis
Descriptor: Probable HTH-type transcriptional regulator YttP
Authors:Krieger, I.V, Brown, E.E, Herman, J.K, Sacchettini, J.C.
Deposit date:2018-09-20
Release date:2019-03-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation.
J.Bacteriol., 201, 2019
1EIO
DownloadVisualize
BU of 1eio by Molmil
ILEAL LIPID BINDING PROTEIN IN COMPLEX WITH GLYCOCHOLATE
Descriptor: GLYCOCHOLIC ACID, ILEAL LIPID BINDING PROTEIN
Authors:Luecke, C, Zhang, F, Hamilton, J.A, Sacchettini, J.C, Rueterjans, H.
Deposit date:2000-02-27
Release date:2000-05-31
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of ileal lipid binding protein in complex with glycocholate.
Eur.J.Biochem., 267, 2000
5H8P
DownloadVisualize
BU of 5h8p by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in apo form
Descriptor: Malate synthase G
Authors:Krieger, I.V, Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-12-23
Release date:2016-10-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5H8M
DownloadVisualize
BU of 5h8m by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase C619A, G459A mutant in complex with product malate
Descriptor: (2S)-2-hydroxybutanedioic acid, MAGNESIUM ION, Malate synthase G
Authors:Krieger, I.V, Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-12-23
Release date:2016-10-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5H8U
DownloadVisualize
BU of 5h8u by Molmil
Crystal structure of mycobacterium tuberculosis wild-type malate synthase in complex with product malate
Descriptor: (2S)-2-hydroxybutanedioic acid, GLYOXYLIC ACID, MAGNESIUM ION, ...
Authors:Krieger, I.V, Huang, H.-L, Sacchettini, J.C.
Deposit date:2015-12-23
Release date:2016-10-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
3VFH
DownloadVisualize
BU of 3vfh by Molmil
BlaC E166A CDC-1 Acyl-Intermediate
Descriptor: (2R)-5-methylidene-2-{(1R)-2-oxo-1-[(phenylacetyl)amino]ethyl}-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Mire, J.A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-01-09
Release date:2012-09-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:BlaC-Specific Fluorogenic Probes for Rapid Tuberculosis Detection
To be Published
3VFF
DownloadVisualize
BU of 3vff by Molmil
BlaC E166A CDC-OMe Acyl-Intermediate Complex
Descriptor: (2R)-2-[(1S)-1-(benzoylamino)-1-methoxy-2-oxoethyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Mire, J.A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-01-09
Release date:2012-09-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.777 Å)
Cite:BlaC-Specific Fluorogenic Probes for Rapid Tuberculosis Detection
To be Published
8TQV
DownloadVisualize
BU of 8tqv by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor X20403
Descriptor: 4-(2-{(4M)-4-[(6M)-6-(2,5-dimethoxyphenyl)pyridin-3-yl]-1H-1,2,3-triazol-1-yl}ethyl)-N-{[1-(methoxymethyl)cyclopropyl]methyl}-N-methylbenzamide, Polyketide synthase Pks13, SULFATE ION
Authors:Krieger, I.V, Sacchettini, J.C.
Deposit date:2023-08-08
Release date:2024-04-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening.
Acs Infect Dis., 2024

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon