4XT4

Crystal structure of Rv2671 from Mycobacteirum tuberculosis in complex with dihydropteridine ring of dihydropteroic acid

Summary for 4XT4

• Entry DOI: 10.2210/pdb4xt4/pdb
• Related: 4XRB 4XT5 4XT6 4XT7 4XT8
• Descriptor: Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-amino-6-methyl-7,8-dihydropteridin-4(3H)-one, ... (5 entities in total)
• Functional Keywords: reductase, pteridine, structural genomics, tb structural genomics consortium, tbsgc, oxidoreductase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 28828.27

Authors

Sacchettini, J.C.,Cheng, Y.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-01-22, release date: 2016-02-24, Last modification date: 2023-09-27)

• Primary citation: Cheng, Y.S.,Sacchettini, J.C.; Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.; Biochemistry, 55:1107-1119, 2016; PubMed: 26848874; DOI: 10.1021/acs.biochem.5b00993

Experimental method

X-RAY DIFFRACTION (1.891 Å)