2J6W
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![BU of 2j6w by Molmil](/molmil-images/mine/2j6w) | R164N mutant of the RUNX1 Runt domain | Descriptor: | CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | Authors: | Grembecka, J, Zhe, L, Lukasik, S.M, Liu, Y, Bielnicka, I, Bushweller, J.H, Speck, N.A. | Deposit date: | 2006-10-04 | Release date: | 2007-10-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation. J.Mol.Biol., 364, 2006
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2QKB
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![BU of 2qkb by Molmil](/molmil-images/mine/2qkb) | Human RNase H catalytic domain mutant D210N in complex with 20-mer RNA/DNA hybrid | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*DGP*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*DTP*DGP*DTP*DCP*DGP*DCP*DAP*DCP*DTP*DCP*DT)-3', 5'-R(*GP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), ... | Authors: | Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. | Deposit date: | 2007-07-10 | Release date: | 2007-11-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription Mol.Cell, 28, 2007
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2QKK
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![BU of 2qkk by Molmil](/molmil-images/mine/2qkk) | Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3', ... | Authors: | Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. | Deposit date: | 2007-07-11 | Release date: | 2007-11-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription Mol.Cell, 28, 2007
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1C4B
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![BU of 1c4b by Molmil](/molmil-images/mine/1c4b) | A BETA-HAIRPIN MIMIC FROM FCERI-ALPHA-CYCLO(RD-262) | Descriptor: | PROTEIN (CYCLO(RD-262)) | Authors: | Mcdonnell, J.M, Fushman, D, Cahill, S.M, Sutton, B.J, Cowburn, D. | Deposit date: | 1999-08-02 | Release date: | 1999-08-25 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution Structures of FceRI Alpha-Chain Mimics: A Beta-Hairpin Peptide and Its Retroenantiomer J.Am.Chem.Soc., 119, 1997
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2QEW
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![BU of 2qew by Molmil](/molmil-images/mine/2qew) | Rat cytosolic PEPCK, in complex with manganese ion. | Descriptor: | MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ... | Authors: | Sullivan, S.M, Holyoak, T. | Deposit date: | 2007-06-26 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry, 46, 2007
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6A4T
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![BU of 6a4t by Molmil](/molmil-images/mine/6a4t) | Crystal structure of Peptidase E from Deinococcus radiodurans R1 | Descriptor: | Peptidase E | Authors: | Yadav, P, Goyal, V.G, Kumar, A, Gokhale, S.M, Makde, R.D. | Deposit date: | 2018-06-20 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Catalytic triad heterogeneity in S51 peptidase family: Structural basis for functional variability. Proteins, 87, 2019
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2IWU
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![BU of 2iwu by Molmil](/molmil-images/mine/2iwu) | Analogues of radicicol bound to the ATP-binding site of Hsp90 | Descriptor: | (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | Authors: | Roe, S.M, Prodromou, C, Pearl, L.H. | Deposit date: | 2006-07-04 | Release date: | 2006-11-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13, 2006
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6A4W
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![BU of 6a4w by Molmil](/molmil-images/mine/6a4w) | AcrR from Mycobacterium tuberculosis | Descriptor: | GLYCEROL, SODIUM ION, SULFATE ION, ... | Authors: | Kang, S.M, Kim, D.H. | Deposit date: | 2018-06-21 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.587 Å) | Cite: | The crystal structure of AcrR from Mycobacterium tuberculosis reveals a one-component transcriptional regulation mechanism. Febs Open Bio, 9, 2019
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6AF3
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![BU of 6af3 by Molmil](/molmil-images/mine/6af3) | |
2J5O
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![BU of 2j5o by Molmil](/molmil-images/mine/2j5o) | Pseudomonas aeruginosa FtsK gamma domain | Descriptor: | DNA TRANSLOCASE FTSK | Authors: | Sivanathan, V, Allen, M.D, deBekker, C, Baker, R, Arciszewska, L, Freund, S.M, Bycroft, M, Lowe, J, Sherratt, D.J. | Deposit date: | 2006-09-19 | Release date: | 2006-10-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Ftsk Gamma Domain Directs Oriented DNA Translocation by Interacting with Kops. Nat.Struct.Mol.Biol., 13, 2006
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2QS9
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![BU of 2qs9 by Molmil](/molmil-images/mine/2qs9) | Crystal structure of the human retinoblastoma-binding protein 9 (RBBP-9). NESG target HR2978 | Descriptor: | Retinoblastoma-binding protein 9 | Authors: | Vorobiev, S.M, Su, M, Seetharaman, J, Kuzin, A, Chen, C.X, Cunningham, K, Owens, L, Maglaqui, M, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-07-30 | Release date: | 2007-08-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Crystal structure of human retinoblastoma binding protein 9. Proteins, 74, 2008
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8BPA
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![BU of 8bpa by Molmil](/molmil-images/mine/8bpa) | Cryo-EM structure of the human SIN3B histone deacetylase complex at 3.7 Angstrom | Descriptor: | CALCIUM ION, Histone deacetylase 2, Isoform 2 of Paired amphipathic helix protein Sin3b, ... | Authors: | Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. | Deposit date: | 2022-11-16 | Release date: | 2023-05-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
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2JAA
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![BU of 2jaa by Molmil](/molmil-images/mine/2jaa) | SeMet substituted Shigella Flexneri Ipad | Descriptor: | INVASIN IPAD | Authors: | Johnson, S, Roversi, P, Espina, M, Olive, A, Deane, J.E, Birket, S, Field, T, Picking, W.D, Blocker, A.J, Galyov, E.E, Picking, W.L, Lea, S.M. | Deposit date: | 2006-11-24 | Release date: | 2006-11-30 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Self-Chaperoning of the Type III Secretion System Needle Tip Proteins Ipad and Bipd. J.Biol.Chem., 282, 2007
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8BPB
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![BU of 8bpb by Molmil](/molmil-images/mine/8bpb) | Cryo-EM structure of the human SIN3B histone deacetylase core complex at 2.8 Angstrom | Descriptor: | ACETATE ION, CALCIUM ION, Histone deacetylase 2, ... | Authors: | Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. | Deposit date: | 2022-11-16 | Release date: | 2023-05-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
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8BPC
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![BU of 8bpc by Molmil](/molmil-images/mine/8bpc) | Cryo-EM structure of the human SIN3B histone deacetylase core complex with SAHA at 2.8 Angstrom | Descriptor: | CALCIUM ION, Histone deacetylase 2, Isoform 2 of Paired amphipathic helix protein Sin3b, ... | Authors: | Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. | Deposit date: | 2022-11-16 | Release date: | 2023-05-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
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2J62
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![BU of 2j62 by Molmil](/molmil-images/mine/2j62) | Structure of a bacterial O-glcnacase in complex with glcnacstatin | Descriptor: | CHLORIDE ION, N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-2-METHYLPROPANAMIDE, O-GlcNAcase NagJ | Authors: | Dorfmueller, H.C, Borodkin, V.S, Schimpl, M, Shepherd, S.M, Shpiro, N.A, van Aalten, D.M.F. | Deposit date: | 2006-09-22 | Release date: | 2007-02-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels. J. Am. Chem. Soc., 128, 2006
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1APM
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![BU of 1apm by Molmil](/molmil-images/mine/1apm) | 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT | Descriptor: | N-OCTANE, PEPTIDE INHIBITOR PKI(5-24), cAMP-DEPENDENT PROTEIN KINASE | Authors: | Knighton, D.R, Bell, S.M, Zheng, J, Teneyck, L.F, Xuong, N.-H, Taylor, S.S, Sowadski, J.M. | Deposit date: | 1993-01-18 | Release date: | 1993-04-15 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent. Acta Crystallogr.,Sect.D, 49, 1993
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2P28
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![BU of 2p28 by Molmil](/molmil-images/mine/2p28) | Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin beta-2 | Authors: | Shi, M, Foo, S.Y, Tan, S.M, Mitchell, E.P, Law, S.K.A, Lescar, J. | Deposit date: | 2007-03-07 | Release date: | 2007-08-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins J.Biol.Chem., 282, 2007
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6AHZ
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![BU of 6ahz by Molmil](/molmil-images/mine/6ahz) | The NMR Structure of the Polysialyltranseferase Domain (PSTD) in Polysialyltransferase ST8siaIV | Descriptor: | CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase | Authors: | Liu, X.H, Lu, B, Peng, L.X, Liao, S.M, Zhou, F, Chen, D, Lu, Z.L, Zhou, G.P, Huang, R.B. | Deposit date: | 2018-08-21 | Release date: | 2018-10-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD). Med Chem, 15, 2019
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1CR5
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![BU of 1cr5 by Molmil](/molmil-images/mine/1cr5) | N-TERMINAL DOMAIN OF SEC18P | Descriptor: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, SEC18P (RESIDUES 22 - 210) | Authors: | Babor, S.M, Fass, D. | Deposit date: | 1999-08-13 | Release date: | 1999-12-22 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the Sec18p N-terminal domain. Proc.Natl.Acad.Sci.USA, 96, 1999
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8DMY
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![BU of 8dmy by Molmil](/molmil-images/mine/8dmy) | Cryo-EM structure of cardiac muscle alpha-actin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | Authors: | Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K. | Deposit date: | 2022-07-09 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural insights into actin isoforms. Elife, 12, 2023
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8BLO
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![BU of 8blo by Molmil](/molmil-images/mine/8blo) | Human Urea Transporter UT-A (N-Terminal Domain Model) | Descriptor: | Lauryl Maltose Neopentyl Glycol, Urea transporter 2, di-heneicosanoyl phosphatidyl choline | Authors: | Chi, G, Pike, A.C.W, Maclean, E.M, Mukhopadhyay, S.M.M, Bohstedt, T, Scacioc, A, Wang, D, McKinley, G, Fernandez-Cid, A, Arrowsmith, C.H, Bountra, C, Edwards, A, Burgess-Brown, N.A, van Putte, W, Duerr, K. | Deposit date: | 2022-11-10 | Release date: | 2023-10-04 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural characterization of human urea transporters UT-A and UT-B and their inhibition. Sci Adv, 9, 2023
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2J0A
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![BU of 2j0a by Molmil](/molmil-images/mine/2j0a) | Structure of the catalytic domain of mouse Manic Fringe | Descriptor: | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, POTASSIUM ION, SULFATE ION | Authors: | Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E. | Deposit date: | 2006-08-01 | Release date: | 2006-09-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe Nat.Struct.Mol.Biol., 13, 2006
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8BLP
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![BU of 8blp by Molmil](/molmil-images/mine/8blp) | Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14 | Descriptor: | 10-(4-ethylphenyl)sulfonyl-~{N}-(thiophen-2-ylmethyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine, CHOLESTEROL HEMISUCCINATE, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Chi, G, Dietz, L, Pike, A.C.W, Maclean, E.M, Mukhopadhyay, S.M.M, Bohstedt, T, Wang, D, Scacioc, A, McKinley, G, Arrowsmith, C.H, Edwards, A, Bountra, C, Fernandez-Cid, A, Burgess-Brown, N.A, Duerr, K.L. | Deposit date: | 2022-11-10 | Release date: | 2023-10-04 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural characterization of human urea transporters UT-A and UT-B and their inhibition. Sci Adv, 9, 2023
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8DNF
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![BU of 8dnf by Molmil](/molmil-images/mine/8dnf) | Cryo-EM structure of nonmuscle gamma-actin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 2, ... | Authors: | Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K. | Deposit date: | 2022-07-11 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structural insights into actin isoforms. Elife, 12, 2023
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