2J62

Structure of a bacterial O-glcnacase in complex with glcnacstatin

Summary for 2J62

• Entry DOI: 10.2210/pdb2j62/pdb
• Descriptor: O-GlcNAcase NagJ, CHLORIDE ION, N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-2-METHYLPROPANAMIDE, ... (4 entities in total)
• Functional Keywords: hydrolase
• Biological source: Clostridium perfringens
• Total number of polymer chains: 2
• Total formula weight: 134270.11

Authors

Dorfmueller, H.C.,Borodkin, V.S.,Schimpl, M.,Shepherd, S.M.,Shpiro, N.A.,van Aalten, D.M.F. (deposition date: 2006-09-22, release date: 2007-02-13, Last modification date: 2018-11-28)

• Primary citation: Dorfmueller, H.C.,Borodkin, V.S.,Schimpl, M.,Shepherd, S.M.,Shpiro, N.A.,van Aalten, D.M.; GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels.; J. Am. Chem. Soc., 128:16484-16485, 2006; PubMed: 17177381; DOI: 10.1021/ja066743n

Experimental method

X-RAY DIFFRACTION (2.26 Å)