8BLP

Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14

Summary for 8BLP

Entry DOI	10.2210/pdb8blp/pdb
EMDB information	16110 16111 16112
Descriptor	Urea transporter 1, PHOSPHATIDYLETHANOLAMINE, DODECYL-BETA-D-MALTOSIDE, ... (6 entities in total)
Functional Keywords	slc14a1, ut1, ut-b, urea transporter, inhibitor, solute carrier, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	155171.46
Authors	Chi, G.,Dietz, L.,Pike, A.C.W.,Maclean, E.M.,Mukhopadhyay, S.M.M.,Bohstedt, T.,Wang, D.,Scacioc, A.,McKinley, G.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Fernandez-Cid, A.,Burgess-Brown, N.A.,Duerr, K.L. (deposition date: 2022-11-10, release date: 2023-10-04, Last modification date: 2023-10-11)
Primary citation	Chi, G.,Dietz, L.,Tang, H.,Snee, M.,Scacioc, A.,Wang, D.,Mckinley, G.,Mukhopadhyay, S.M.M.,Pike, A.C.W.,Chalk, R.,Burgess-Brown, N.A.,Timmermans, J.P.,van Putte, W.,Robinson, C.V.,Durr, K.L. Structural characterization of human urea transporters UT-A and UT-B and their inhibition. Sci Adv, 9:eadg8229-eadg8229, 2023 Cited by PubMed: 37774028 DOI: 10.1126/sciadv.adg8229 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.6 Å)

Structure validation