8BLP

Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005372	molecular_function	water transmembrane transporter activity
A	0005886	cellular_component	plasma membrane
A	0006833	biological_process	water transport
A	0015204	molecular_function	urea transmembrane transporter activity
A	0015265	molecular_function	urea channel activity
A	0015840	biological_process	urea transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0051649	biological_process	establishment of localization in cell
A	0055085	biological_process	transmembrane transport
A	0071918	biological_process	urea transmembrane transport
B	0005372	molecular_function	water transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0006833	biological_process	water transport
B	0015204	molecular_function	urea transmembrane transporter activity
B	0015265	molecular_function	urea channel activity
B	0015840	biological_process	urea transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0051649	biological_process	establishment of localization in cell
B	0055085	biological_process	transmembrane transport
B	0071918	biological_process	urea transmembrane transport
C	0005372	molecular_function	water transmembrane transporter activity
C	0005886	cellular_component	plasma membrane
C	0006833	biological_process	water transport
C	0015204	molecular_function	urea transmembrane transporter activity
C	0015265	molecular_function	urea channel activity
C	0015840	biological_process	urea transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0051649	biological_process	establishment of localization in cell
C	0055085	biological_process	transmembrane transport
C	0071918	biological_process	urea transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00079
Number of Residues	21
Details	MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GlWgFnSsLAciAmGGMfmaL

Chain	Residue	Details
A	GLY284-LEU304

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	537
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	PRO53-ASN73
B	PRO53-ASN73
B	TRP91-LEU110
B	LEU116-PHE136
B	PHE143-ALA163
B	LEU173-HIS193
B	GLY242-ILE262
B	ILE281-PHE301
B	LEU310-MET330
B	VAL333-THR353
C	PRO53-ASN73
A	TRP91-LEU110
C	TRP91-LEU110
C	LEU116-PHE136
C	PHE143-ALA163
C	LEU173-HIS193
C	GLY242-ILE262
C	ILE281-PHE301
C	LEU310-MET330
C	VAL333-THR353
A	LEU116-PHE136
A	PHE143-ALA163
A	LEU173-HIS193
A	GLY242-ILE262
A	ILE281-PHE301
A	LEU310-MET330
A	VAL333-THR353

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Important for channel permeability => ECO:0000250|UniProtKB:Q5QF96

Chain	Residue	Details
A	THR339
B	THR339
C	THR339

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site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	GLN211
B	GLN211
C	GLN211

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