8BLP
Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Urea transporter 1 | polymer | 367 | 40177.4 | 3 | UniProt (Q13336) Pfam (PF03253) | Homo sapiens (human) | Solute carrier family 14 member 1,Urea transporter,erythrocyte |
| 2 | BA, D, DB, HA, J... (B, A, C) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 6 | Chemie (PTY) | |||
| 3 | AA, AB, BB, CA, CB... (B, C, A) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 51 | Chemie (LMT) | |||
| 4 | PB, QB, TA, UA, V... (C, B, A) | 10-(4-ethylphenyl)sulfonyl-~{N}-(thiophen-2-ylmethyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine | non-polymer | 455.6 | 6 | Chemie (5D3) | |||
| 5 | VA, X, Z (C, A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 3 | Chemie (Y01) | |||
| 6 | RB, SB, TB (A, B, C) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A, B, C: 31 - 389 (UniProt: Q13336)
| PDB | External Database | Details |
|---|---|---|
| Met 30 | - | initiating methionine |
| Val 167 | Met 167 | conflict |
| Gln 211 | Asn 211 | engineered mutation |
| Asn 280 | Asp 280 | conflict |
| Ala 390 | - | expression tag |
| Glu 391 | - | expression tag |
| Asn 392 | - | expression tag |
| Leu 393 | - | expression tag |
| Tyr 394 | - | expression tag |
| Phe 395 | - | expression tag |
| Gln 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 120532.2 | |
| Non-Polymers* | Number of molecules | 66 |
| Total formula weight | 34639.2 | |
| All* | Total formula weight | 155171.5 |
