8BLP
Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Urea transporter 1 | polymer | 367 | 40177.4 | 3 | UniProt (Q13336) Pfam (PF03253) | Homo sapiens (human) | Solute carrier family 14 member 1,Urea transporter,erythrocyte |
| 2 | BA, D, DB, HA, J... (B, A, C) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 6 | Chemie (PTY) PubChem (446872) PubChem (3330137) | |||
| 3 | AA, AB, BB, CA, CB... (B, C, A) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 51 | Chemie (LMT) | |||
| 4 | PB, QB, TA, UA, V... (C, B, A) | 10-(4-ethylphenyl)sulfonyl-~{N}-(thiophen-2-ylmethyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine | non-polymer | 455.6 | 6 | Chemie (5D3) PubChem (16019476) | |||
| 5 | VA, X, Z (C, A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 3 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (363416) PubChem (45489984) PubChem (500055) PubChem (60078761) PubChem (57163942) PubChem (73440805) PubChem (89891013) PubChem (13301926) PubChem (13301927) PubChem (99567469) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (137392566) PubChem (137496323) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (155804219) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (169132514) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 6 | RB, SB, TB (A, B, C) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A, B, C: 31 - 389 (UniProt: Q13336)
| PDB | External Database | Details |
|---|---|---|
| Met 30 | - | initiating methionine |
| Val 167 | Met 167 | conflict |
| Gln 211 | Asn 211 | engineered mutation |
| Asn 280 | Asp 280 | conflict |
| Ala 390 | - | expression tag |
| Glu 391 | - | expression tag |
| Asn 392 | - | expression tag |
| Leu 393 | - | expression tag |
| Tyr 394 | - | expression tag |
| Phe 395 | - | expression tag |
| Gln 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 120532.2 | |
| Non-Polymers* | Number of molecules | 66 |
| Total formula weight | 34639.2 | |
| All* | Total formula weight | 155171.5 |
