2QKB

Human RNase H catalytic domain mutant D210N in complex with 20-mer RNA/DNA hybrid

Summary for 2QKB

• Entry DOI: 10.2210/pdb2qkb/pdb
• Related: 2QK9 2QKK
• Descriptor: 5'-R(*GP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), 5'-D(*DGP*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*DTP*DGP*DTP*DCP*DGP*DCP*DAP*DCP*DTP*DCP*DT)-3', Ribonuclease H1, ... (6 entities in total)
• Functional Keywords: rnase h; rna/dna hybrid, hydrolase-dna-rna complex, hydrolase/dna/rna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (Potential): O60930
• Total number of polymer chains: 4
• Total formula weight: 47432.82

Authors

Nowotny, M.,Gaidamakov, S.A.,Ghirlando, R.,Cerritelli, S.M.,Crouch, R.J.,Yang, W. (deposition date: 2007-07-10, release date: 2007-11-13, Last modification date: 2023-11-15)

• Primary citation: Nowotny, M.,Gaidamakov, S.A.,Ghirlando, R.,Cerritelli, S.M.,Crouch, R.J.,Yang, W.; Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription; Mol.Cell, 28:264-276, 2007; PubMed: 17964265; DOI: 10.1016/j.molcel.2007.08.015

Experimental method

X-RAY DIFFRACTION (2.4 Å)