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PDB: 13 results

1KZ7
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BU of 1kz7 by Molmil
Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42
Descriptor: CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Authors:Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1KZG
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BU of 1kzg by Molmil
DbsCdc42(Y889F)
Descriptor: CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Authors:Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
4YOB
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BU of 4yob by Molmil
Crystal Structure of Apo HIV-1 Protease MDR769 L33F
Descriptor: HIV-1 Protease
Authors:Kuiper, B.D, Keusch, B, Dewdney, T.G, Chordia, P, Ross, K, Brunzelle, J.S, Kovari, I.A, MacArthur, R, Salimnia, H, Kovari, L.C.
Deposit date:2015-03-11
Release date:2015-07-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.504 Å)
Cite:The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.
Biochem Biophys Rep, 2, 2015
4YOA
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Crsystal structure HIV-1 Protease MDR769 L33F Complexed with darunavir
Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, HIV-1 Protease
Authors:Kuiper, B.D, Keusch, B, Dewdney, T.G, Chordia, P, Brunzelle, J.S, Ross, K, Kovari, I.A, MacArthur, R, Salimnia, H, Kovari, L.C.
Deposit date:2015-03-11
Release date:2015-07-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.
Biochem Biophys Rep, 2, 2015
1FOE
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BU of 1foe by Molmil
CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Descriptor: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE, SULFATE ION, T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1
Authors:Worthylake, D.K, Rossman, K.L, Sondek, J.
Deposit date:2000-08-27
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature, 408, 2000
1X7A
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BU of 1x7a by Molmil
Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Descriptor: 1-{3-[AMINO(IMINO)METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE, Coagulation Factor IX, light chain, ...
Authors:Alexander, R.S, Smallwood, A.M, Smallheer, J.M, Wang, J, Wang, S, Nakajima, S, Rossi, K.A, Barbera, F, Burdick, D, Luettgen, J.M.
Deposit date:2004-08-13
Release date:2005-08-16
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
Bioorg.Med.Chem.Lett., 14, 2004
1LB1
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Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA
Descriptor: Guanine nucleotide exchange factor DBS, Transforming protein RhoA
Authors:Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J.
Deposit date:2002-04-01
Release date:2002-05-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
1RJ2
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BU of 1rj2 by Molmil
Crystal structure of the DH/PH fragment of Dbs without bound GTPase
Descriptor: Guanine nucleotide exchange factor DBS [Fragment]
Authors:Worthylake, D.K, Rossman, K.L, Sondek, J.
Deposit date:2003-11-18
Release date:2004-06-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Structure, 12, 2004
2PZ1
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BU of 2pz1 by Molmil
Crystal Structure of Auto-inhibited Asef
Descriptor: Rho guanine nucleotide exchange factor 4
Authors:Betts, L, Sondek, J, Rossman, K.L.
Deposit date:2007-05-17
Release date:2007-08-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
8ECR
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BU of 8ecr by Molmil
KRAS4b WT 1-185 bound to GDP-Mg2+
Descriptor: GLYCEROL, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Betts, L, Rossman, K.L.
Deposit date:2022-09-02
Release date:2023-09-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:KRAS4b WT 1-185 bound to GDP-Mg2+
To Be Published
8EDY
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KRAS4b A146T 1-185 bound to GDP
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Betts, L, Rossman, K.L.
Deposit date:2022-09-06
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:KRAS4b A146T 1-185 bound to GDP
To Be Published
8EER
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BU of 8eer by Molmil
KRAS4B A146V 1-185 bound to GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Isoform 4b of the GTPase KRAS
Authors:Betts, L, Rossman, K.L.
Deposit date:2022-09-07
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:KRAS4B A146V 1-185 bound to GDP
To Be Published
8EIE
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BU of 8eie by Molmil
KRAS4b K117N 1-185 bound to GNP-Mg2+
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Betts, L, Rossman, K.L.
Deposit date:2022-09-14
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:A crystallographic view of the fast-cycling KRAS mutant, K117N
To Be Published

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PDB entries from 2024-10-30

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