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PDB: 119 results

1YNL
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Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic sweeterners: Crystal structure of NC6.8 co-crystalized with high potency sweetener compound SC45647
Descriptor: 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID, Ig gamma heavy chain, Ig gamma light chain
Authors:Gokulan, K, Khare, S, Ronning, D.R, Linthicum, S.D, Sacchettini, J.C, Rupp, B.
Deposit date:2005-01-24
Release date:2005-08-16
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cocrystal Structures of NC6.8 Fab Identify Key Interactions for High Potency Sweetener Recognition: Implications for the Design of Synthetic Sweeteners
Biochemistry, 44, 2005
4MQL
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Crystal structure of Antigen 85C-C209S mutant
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Diacylglycerol acyltransferase/mycolyltransferase Ag85C
Authors:Favrot, L, Grzegorzewicz, A.E, Lajiness, D.H, Marvin, R.K, Boucau, J, Isailovic, D, Jackson, M, Ronning, D.R.
Deposit date:2013-09-16
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen.
Nat Commun, 4, 2013
8FX9
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Crystal strucutre of Mycobacterium tuberculosis Mycothiol-S-transferase enzyme
Descriptor: CHLORIDE ION, Mycothiol-S-transferase
Authors:Lindenberger, J.J, Jayasinghe, Y.P, Ronning, D.R.
Deposit date:2023-01-24
Release date:2023-04-05
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:The Mycobacterium tuberculosis mycothiol S -transferase is divalent metal-dependent for mycothiol binding and transfer.
Rsc Med Chem, 14, 2023
4OY3
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Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with S-Adenosylhomocysteine in the active site
Descriptor: Aminodeoxyfutalosine nucleosidase, CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Mishra, V, Ronning, D.R.
Deposit date:2014-02-10
Release date:2014-12-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
Biochemistry, 51, 2012
5KWI
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M.tb Ag85C modified at C209 by adamantyl-ebselen
Descriptor: Diacylglycerol acyltransferase/mycolyltransferase Ag85C, ~{N}-(1-adamantyl)-2-selanyl-benzamide
Authors:Goins, C.M, Ronning, D.R.
Deposit date:2016-07-18
Release date:2017-03-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives.
ACS Infect Dis, 3, 2017
4OJT
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Helicobacter pylori MTAN complexed with S-ribosylhomocysteine and adenine
Descriptor: ADENINE, MTA/SAH nucleosidase, S-ribosylhomocysteine
Authors:Mishra, V, Ronning, D.R.
Deposit date:2014-01-21
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
Biochemistry, 51, 2012
4QEK
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BU of 4qek by Molmil
Crystal structure of Antigen 85C-S124A mutant
Descriptor: Diacylglycerol acyltransferase/mycolyltransferase Ag85C, SULFATE ION, alpha-D-glucopyranose
Authors:Favrot, L, Lajiness, D.H, Ronning, D.R.
Deposit date:2014-05-16
Release date:2014-07-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.299 Å)
Cite:Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
J.Biol.Chem., 289, 2014
4QDZ
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BU of 4qdz by Molmil
Crystal structure of Antigen 85C-E228Q mutant
Descriptor: ACETATE ION, Diacylglycerol acyltransferase/mycolyltransferase Ag85C, HEXAETHYLENE GLYCOL
Authors:Favrot, L, Lajiness, D.H, Ronning, D.R.
Deposit date:2014-05-14
Release date:2014-07-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.885 Å)
Cite:Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
J.Biol.Chem., 289, 2014
4QDU
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BU of 4qdu by Molmil
Crystal structure of Antigen 85C co-crystallized with ebselen
Descriptor: Diacylglycerol acyltransferase/mycolyltransferase Ag85C
Authors:Favrot, L, Lajiness, D.H, Ronning, D.R.
Deposit date:2014-05-14
Release date:2014-07-09
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
J.Biol.Chem., 289, 2014
4QE3
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BU of 4qe3 by Molmil
Crystal structure of Antigen 85C-H260Q mutant
Descriptor: ACETIC ACID, CHAPSO, Diacylglycerol acyltransferase/mycolyltransferase Ag85C
Authors:Favrot, L, Lajiness, D.H, Ronning, D.R.
Deposit date:2014-05-15
Release date:2014-07-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.351 Å)
Cite:Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
J.Biol.Chem., 289, 2014
4QDT
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BU of 4qdt by Molmil
Crystal structure of Antigen 85C co-crystallized with iodoacetamide
Descriptor: Diacylglycerol acyltransferase/mycolyltransferase Ag85C
Authors:Favrot, L, Lajiness, D.H, Ronning, D.R.
Deposit date:2014-05-14
Release date:2014-07-09
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
J.Biol.Chem., 289, 2014
4QDX
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BU of 4qdx by Molmil
Crystal structure of Antigen 85C-C209G mutant
Descriptor: Diacylglycerol acyltransferase/mycolyltransferase Ag85C, SULFATE ION
Authors:Favrot, L, Lajiness, D.H, Ronning, D.R.
Deposit date:2014-05-14
Release date:2014-07-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.503 Å)
Cite:Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
J.Biol.Chem., 289, 2014
4QDO
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BU of 4qdo by Molmil
Crystal structure of Ag85C co-crystallized with p-chloromercuribenzoic acid
Descriptor: ACETATE ION, Diacylglycerol acyltransferase/mycolyltransferase Ag85C
Authors:Favrot, L, Lajiness, D.H, Ronning, D.R.
Deposit date:2014-05-14
Release date:2014-07-09
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
J.Biol.Chem., 289, 2014
4V0V
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BU of 4v0v by Molmil
The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-660)
Descriptor: MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT, ...
Authors:Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J.
Deposit date:2014-09-18
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
4V0U
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The crystal structure of ternary PP1G-PPP1R15B and G-actin complex
Descriptor: ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J.
Deposit date:2014-09-18
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (7.88 Å)
Cite:G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
4V0W
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BU of 4v0w by Molmil
The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-669)
Descriptor: MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
Authors:Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J.
Deposit date:2014-09-18
Release date:2015-03-25
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
4V0X
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BU of 4v0x by Molmil
The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-684)
Descriptor: MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
Authors:Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J.
Deposit date:2014-09-18
Release date:2015-03-25
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
6EOE
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BU of 6eoe by Molmil
Crystal structure of AMPylated GRP78 with nucleotide
Descriptor: 78 kDa glucose-regulated protein, ADENOSINE-5'-DIPHOSPHATE, CITRATE ANION, ...
Authors:Yan, Y, Preissler, S, Ron, D, Read, R.J.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
6EOB
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BU of 6eob by Molmil
Crystal structure of AMPylated GRP78 in apo form (Crystal form 1)
Descriptor: 78 kDa glucose-regulated protein, PHOSPHATE ION
Authors:Yan, Y, Preissler, S, Ron, D, Read, R.J.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
7NXV
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BU of 7nxv by Molmil
Crystal structure of the complex of DNase I/G-actin/PPP1R15A_582-621
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Yan, Y, Ron, D.
Deposit date:2021-03-19
Release date:2021-09-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Nat.Struct.Mol.Biol., 28, 2021
7NZM
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BU of 7nzm by Molmil
Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Yan, Y, Hardwick, S, Ron, D.
Deposit date:2021-03-24
Release date:2021-09-29
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Nat.Struct.Mol.Biol., 28, 2021
6ZYI
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BU of 6zyi by Molmil
Crystal structure of HSP70 ATPase domain in complex with ADP and calcium
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70kDa protein 1A variant
Authors:Yan, Y, Preissler, S, Ron, D.
Deposit date:2020-08-01
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
6ZYJ
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BU of 6zyj by Molmil
Crystal structure of Hsc70 ATPase domain in complex with ADP and calcium
Descriptor: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:Yan, Y, Preissler, S, Ron, D.
Deposit date:2020-08-01
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
7A4V
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BU of 7a4v by Molmil
Crystal structure of lid-truncated ADP-bound BiP in an oligomeric state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmic reticulum chaperone BiP, GLYCEROL, ...
Authors:Perera, L.A, Ron, D.
Deposit date:2020-08-20
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
6ZYH
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BU of 6zyh by Molmil
Crystal structure of GRP78 (70kDa heat shock protein 5 / BiP) ATPase domain in complex with ADP and calcium
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Endoplasmic reticulum chaperone BiP
Authors:Yan, Y, Preissler, S, Ron, D.
Deposit date:2020-08-01
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020

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