1YNL

Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic sweeterners: Crystal structure of NC6.8 co-crystalized with high potency sweetener compound SC45647

Summary for 1YNL

• Entry DOI: 10.2210/pdb1ynl/pdb
• Related: 1YNK
• Descriptor: Ig gamma light chain, Ig gamma heavy chain, 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: triethyl aminomethane sulfonyl acid, sweetener compound, sc45647 and nc174, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 47726.14

Authors

Gokulan, K.,Khare, S.,Ronning, D.R.,Linthicum, S.D.,Sacchettini, J.C.,Rupp, B. (deposition date: 2005-01-24, release date: 2005-08-16, Last modification date: 2018-01-31)

• Primary citation: Gokulan, K.,Khare, S.,Ronning, D.R.,Linthicum, S.D.,Sacchettini, J.C.,Rupp, B.; Cocrystal Structures of NC6.8 Fab Identify Key Interactions for High Potency Sweetener Recognition: Implications for the Design of Synthetic Sweeteners; Biochemistry, 44:9889-9898, 2005; PubMed: 16026161; DOI: 10.1021/bi050613u

Experimental method

X-RAY DIFFRACTION (1.7 Å)