6WMI
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![BU of 6wmi by Molmil](/molmil-images/mine/6wmi) | ZNF410 zinc fingers 1-5 with 17 mer blunt DNA Oligonucleotide | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*CP*AP*TP*AP*AP*TP*AP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*TP*AP*TP*GP*GP*GP*AP*TP*GP*TP*G)-3'), ... | Authors: | Ren, R, Horton, J.R, Cheng, X. | Deposit date: | 2020-04-21 | Release date: | 2020-12-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Mol.Cell, 81, 2021
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4Q5W
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![BU of 4q5w by Molmil](/molmil-images/mine/4q5w) | Crystal structure of extended-Tudor 9 of Drosophila melanogaster | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Maternal protein tudor | Authors: | Ren, R, Liu, H, Wang, W, Wang, M, Yang, N, Dong, Y, Gong, W, Lehmann, R, Xu, R.M. | Deposit date: | 2014-04-17 | Release date: | 2014-05-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Structure and domain organization of Drosophila Tudor Cell Res., 24, 2014
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6X8Z
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![BU of 6x8z by Molmil](/molmil-images/mine/6x8z) | Crystal structure of N-truncated human B12 chaperone CblD(C262S)-thiolato-cob(III)alamin complex (108-296) | Descriptor: | COBALAMIN, Methylmalonic aciduria and homocystinuria type D protein, mitochondrial | Authors: | Mascarenhas, R, Li, Z, Koutmos, M, Banerjee, R. | Deposit date: | 2020-06-02 | Release date: | 2020-09-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | An Interprotein Co-S Coordination Complex in the B 12 -Trafficking Pathway. J.Am.Chem.Soc., 142, 2020
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5VWQ
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![BU of 5vwq by Molmil](/molmil-images/mine/5vwq) | E.coli Aspartate aminotransferase-(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP) | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase | Authors: | Mascarenhas, R, Lehrer, H, Liu, D, Ringe, D. | Deposit date: | 2017-05-22 | Release date: | 2017-08-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry, 56, 2017
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4FSC
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![BU of 4fsc by Molmil](/molmil-images/mine/4fsc) | Crystal Structure of Bacillus thuringiensis PlcR in its apo form | Descriptor: | Transcriptional activator PlcR protein | Authors: | Grenha, R, Slamti, L, Bouillaut, L, Lereclus, D, Nessler, S. | Deposit date: | 2012-06-27 | Release date: | 2013-03-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR. Proc.Natl.Acad.Sci.USA, 110, 2013
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7RUU
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![BU of 7ruu by Molmil](/molmil-images/mine/7ruu) | Structure of Human ATP:Cobalamin Adenosyltransferase R190C bound to adenosylcobalamin | Descriptor: | 5'-DEOXYADENOSINE, ACETATE ION, COBALAMIN, ... | Authors: | Mascarenhas, R, Gouda, H, Koutmos, M, Banerjee, R. | Deposit date: | 2021-08-18 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions. J.Biol.Chem., 297, 2021
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7RUT
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![BU of 7rut by Molmil](/molmil-images/mine/7rut) | Structure of Human ATP:Cobalamin Adenosyltransferase R190C bound to ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Corrinoid adenosyltransferase, GLYCEROL, ... | Authors: | Mascarenhas, R, Gouda, H, Koutmos, M, Banerjee, R. | Deposit date: | 2021-08-18 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions. J.Biol.Chem., 297, 2021
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7RUV
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![BU of 7ruv by Molmil](/molmil-images/mine/7ruv) | Structure of Human ATP:Cobalamin Adenosyltransferase E193K bound to adenosylcobalamin | Descriptor: | 5'-DEOXYADENOSINE, COBALAMIN, Corrinoid adenosyltransferase, ... | Authors: | Mascarenhas, R, Gouda, H, Koutmos, M, Banerjee, R. | Deposit date: | 2021-08-18 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions. J.Biol.Chem., 297, 2021
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1N2V
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![BU of 1n2v by Molmil](/molmil-images/mine/1n2v) | Crystal Structure of TGT in complex with 2-Butyl-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione | Descriptor: | 2-BUTYL-5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE, Queuine tRNA-ribosyltransferase, ZINC ION | Authors: | Brenk, R, Naerum, L, Graedler, U, Gerber, H.-D, Garcia, G.A, Reuter, K, Stubbs, M.T, Klebe, G. | Deposit date: | 2002-10-24 | Release date: | 2003-04-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis J.Med.Chem., 46, 2003
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6M8H
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![BU of 6m8h by Molmil](/molmil-images/mine/6m8h) | Crystal Structure of the R208Q mutant of G(i) subunit alpha-1 | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION | Authors: | Mascarenhas, R, Goossens, J, Leverson, B, Kothawala, S, Ballicora, M, Olsen, K, de freitas, D, Liu, D. | Deposit date: | 2018-08-21 | Release date: | 2019-08-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | FUNCTIONAL CONSEQUENCES OF ONCOGENIC MUTATIONS IN THE SWITCH II REGION OF Galphai1 and Galphas PROTEINS To Be Published
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8U4K
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![BU of 8u4k by Molmil](/molmil-images/mine/8u4k) | Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betacellulin, ... | Authors: | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | Deposit date: | 2023-09-10 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain To Be Published
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8U4J
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![BU of 8u4j by Molmil](/molmil-images/mine/8u4j) | Structure of the HER4/BTC Homodimer Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betacellulin, ... | Authors: | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | Deposit date: | 2023-09-10 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of the HER4/BTC Homodimer Extracellular Domain To Be Published
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8U4I
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![BU of 8u4i by Molmil](/molmil-images/mine/8u4i) | Structure of the HER4/NRG1b Homodimer Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | Authors: | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | Deposit date: | 2023-09-10 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain To Be Published
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8U4L
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![BU of 8u4l by Molmil](/molmil-images/mine/8u4l) | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | Authors: | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | Deposit date: | 2023-09-10 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain To Be Published
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5KJX
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![BU of 5kjx by Molmil](/molmil-images/mine/5kjx) | Co-crystal Structure of PKA RI alpha CNB-B domain with cAMP | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit | Authors: | Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W. | Deposit date: | 2016-06-20 | Release date: | 2017-06-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochem. J., 474, 2017
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5KJY
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![BU of 5kjy by Molmil](/molmil-images/mine/5kjy) | Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cAMP | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit | Authors: | Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W. | Deposit date: | 2016-06-20 | Release date: | 2017-06-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochem. J., 474, 2017
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5KJZ
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![BU of 5kjz by Molmil](/molmil-images/mine/5kjz) | Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cGMP | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory subunit | Authors: | Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W. | Deposit date: | 2016-06-20 | Release date: | 2017-06-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.347 Å) | Cite: | Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochem. J., 474, 2017
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8STW
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![BU of 8stw by Molmil](/molmil-images/mine/8stw) | K384N HUMAN CYSTATHIONINE BETA-SYNTHASE (delta 411-551) | Descriptor: | Cystathionine beta-synthase, K384N variant, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Mascarenhas, R, Roman, J, Banerjee, R. | Deposit date: | 2023-05-11 | Release date: | 2023-11-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Disease-causing cystathionine beta-synthase linker mutations impair allosteric regulation. J.Biol.Chem., 299, 2023
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8FH5
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![BU of 8fh5 by Molmil](/molmil-images/mine/8fh5) | Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-001 | Descriptor: | (8-oxo-7-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetic acid, Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Arenas, R, Wilson, D.K. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-001 To Be Published
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8FHC
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![BU of 8fhc by Molmil](/molmil-images/mine/8fhc) | Protein 41 with aldehyde deformylating oxidase activity from Gamma proteobacterium | Descriptor: | BROMIDE ION, CHOLIC ACID, FE (III) ION, ... | Authors: | Arenas, R, Wilson, D.K, Mak, W.S, Siegel, J.B. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.097 Å) | Cite: | Protein 41 with aldehyde deformylating oxidase activity from Gamma proteobacterium To Be Published
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8FH6
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![BU of 8fh6 by Molmil](/molmil-images/mine/8fh6) | Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001 | Descriptor: | (8-oxo-7-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, ... | Authors: | Arenas, R, Wilson, D.K. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001 To Be Published
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8FH7
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![BU of 8fh7 by Molmil](/molmil-images/mine/8fh7) | |
8FH9
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![BU of 8fh9 by Molmil](/molmil-images/mine/8fh9) | Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-007 | Descriptor: | (4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, ... | Authors: | Arenas, R, Wilson, D.K. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-007 To Be Published
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8FIF
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![BU of 8fif by Molmil](/molmil-images/mine/8fif) | |
8FHB
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![BU of 8fhb by Molmil](/molmil-images/mine/8fhb) | |