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PDB: 722 results

6RO0
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BU of 6ro0 by Molmil
CRYSTAL STRUCTURE OF GENETICALLY DETOXIFIED PERTUSSIS TOXIN GDPT.
Descriptor: GLYCEROL, Islet-activating protein S2, Islet-activating protein S3, ...
Authors:Bertrand, T.
Deposit date:2019-05-10
Release date:2020-06-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity.
Commun Biol, 3, 2020
6VC8
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BU of 6vc8 by Molmil
Crystal structure of wild-type KRAS4b(1-169) in complex with GMPPNP and Mg ion
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Tran, T.H, Davies, D.R, Edwards, T.E, Simanshu, D.K.
Deposit date:2019-12-20
Release date:2021-02-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.
Proc.Natl.Acad.Sci.USA, 119, 2022
3L9G
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BU of 3l9g by Molmil
Urate oxidase complexed with uric acid and chloride
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, CHLORIDE ION, SODIUM ION, ...
Authors:Prange, T, Colloc'h, N, Gabison, L.
Deposit date:2010-01-05
Release date:2010-06-02
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Acta Crystallogr.,Sect.D, 66, 2010
2LWB
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BU of 2lwb by Molmil
Structural model of BAD-1 repeat loop by NMR
Descriptor: Adhesin WI-1
Authors:Brandhorst, T, Klein, B, Tonelli, M.
Deposit date:2012-07-26
Release date:2013-07-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure and function of a fungal adhesin that mimics thrombospondin-1 by binding heparin sulfate glycosaminoglycan and suppressing T cell activation via interaction with CD47
To be Published
7PUF
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BU of 7puf by Molmil
urate oxidase azaxanthine complex under 600 bar (60 MPa) of argon
Descriptor: 8-AZAXANTHINE, ARGON, SODIUM ION, ...
Authors:Prange, T, Colloc'h, N, Carpentier, P.
Deposit date:2021-09-29
Release date:2022-02-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization
Acta Cryst. D, 78, 2022
6VJJ
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BU of 6vjj by Molmil
Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Tran, T.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-01-16
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
3I7Z
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BU of 3i7z by Molmil
Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ...
Authors:Brandao, T.A.S, Johnson, S.J, Hengge, A.C.
Deposit date:2009-07-09
Release date:2010-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.
J.Biol.Chem., 285, 2010
6GDD
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BU of 6gdd by Molmil
DIHYDROOROTASE FROM AQUIFEX AEOLICUS UNDER 1200 BAR OF HYDROSTATIC PRESSURE
Descriptor: Dihydroorotase, SULFATE ION, ZINC ION
Authors:Prange, T, Girard, E, Herve, G, Evans, D.R.
Deposit date:2018-04-23
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Pressure-induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography.
Febs J., 286, 2019
3I80
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BU of 3i80 by Molmil
Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ...
Authors:Brandao, T.A.S, Johnson, S.J, Hengge, A.C.
Deposit date:2009-07-09
Release date:2010-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.
J.Biol.Chem., 285, 2010
6GDF
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BU of 6gdf by Molmil
DIHYDROOROTASE FROM AQUIFEX AEOLICUS UNDER 600 BAR OF HYDROSTATIC PRESSURE
Descriptor: Dihydroorotase, SULFATE ION, ZINC ION
Authors:Prange, T, Girard, E, Herve, G, Evans, D.R.
Deposit date:2018-04-23
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pressure-induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography.
Febs J., 286, 2019
8EPW
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BU of 8epw by Molmil
Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2022-10-06
Release date:2023-06-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D .
Commun Biol, 6, 2023
8STN
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BU of 8stn by Molmil
Crystal structure of KRAS-G12D/G75A mutant, GDP-bound
Descriptor: CHLORIDE ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tran, T.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2023-05-10
Release date:2023-08-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity.
Cancer Res., 83, 2023
8STM
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BU of 8stm by Molmil
Crystal structure of KRAS-G75A mutant, GDP-bound
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Tran, T.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2023-05-10
Release date:2023-08-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity.
Cancer Res., 83, 2023
3F99
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BU of 3f99 by Molmil
W354F Yersinia enterocolitica PTPase apo form
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase yopH
Authors:Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C.
Deposit date:2008-11-13
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
5LX3
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BU of 5lx3 by Molmil
CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782.
Descriptor: 6-[4-[(6-azanylpyridin-3-yl)methylcarbamoylamino]-3-fluoranyl-phenyl]-2-(ethylamino)-~{N}-(2-piperidin-1-ylethyl)pyridine-3-carboxamide, Nicotinamide phosphoribosyltransferase
Authors:Bertrand, T, Marquette, J.P.
Deposit date:2016-09-20
Release date:2017-10-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782.
To Be Published
6WS4
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BU of 6ws4 by Molmil
Crystal structure of KRAS-G12D/K104Q mutant, GDP-bound
Descriptor: 3,3',3''-phosphanetriyltripropanoic acid, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tran, T.H, Simanshu, D.K.
Deposit date:2020-04-30
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Allosteric regulation of switch-II domain controls KRAS oncogenicity.
Cancer Res., 2023
6WS2
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BU of 6ws2 by Molmil
Crystal structure of KRAS-K104Q mutant, GDP-bound
Descriptor: CHLORIDE ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tran, T.H, Simanshu, D.K.
Deposit date:2020-04-30
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Allosteric regulation of switch-II domain controls KRAS oncogenicity.
Cancer Res., 2023
1C1M
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BU of 1c1m by Molmil
PORCINE ELASTASE UNDER XENON PRESSURE (8 BAR)
Descriptor: CALCIUM ION, PROTEIN (PORCINE ELASTASE), SULFATE ION, ...
Authors:Prange, T, Schiltz, M, Pernot, L, Colloc'h, N, Longhi, S, Bourguet, W, Fourme, R.
Deposit date:1999-07-22
Release date:1999-07-28
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploring hydrophobic sites in proteins with xenon or krypton.
Proteins, 30, 1998
1C3L
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BU of 1c3l by Molmil
SUBTILISIN-CARLSBERG COMPLEXED WITH XENON (8 BAR)
Descriptor: CALCIUM ION, FORMIC ACID, SUBTILISIN-CARLSBERG, ...
Authors:Prange, T, Schiltz, M, Pernot, L, Colloc'h, N, Longhi, S.
Deposit date:1999-07-28
Release date:1999-08-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Exploring hydrophobic sites in proteins with xenon or krypton.
Proteins, 30, 1998
6XHA
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BU of 6xha by Molmil
Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Descriptor: CHLORIDE ION, GLYCEROL, Isoform 2B of GTPase KRas, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-06-18
Release date:2021-01-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
6XGV
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BU of 6xgv by Molmil
Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Descriptor: CHLORIDE ION, GLYCEROL, GTPase KRas, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-06-18
Release date:2021-01-13
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
8F5X
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BU of 8f5x by Molmil
Crystal structure of human eosinophil-derived neurotoxin (EDN, ribonuclease 2) in complex with 5'-adenosine monophosphate (AMP)
Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, Non-secretory ribonuclease, ...
Authors:Tran, T.T.Q, Pham, N.T.H, Calmettes, C, Doucet, N.
Deposit date:2022-11-15
Release date:2023-11-29
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases.
J.Biol.Chem., 300, 2024
6XHB
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BU of 6xhb by Molmil
Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II)
Descriptor: CHLORIDE ION, GLYCEROL, GTPase KRas, ...
Authors:Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
Deposit date:2020-06-18
Release date:2021-01-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
3F9A
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BU of 3f9a by Molmil
W354F Yersinia enterocolitica PTPase complexed with tungstate
Descriptor: TUNGSTATE(VI)ION, Tyrosine-protein phosphatase yopH
Authors:Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C.
Deposit date:2008-11-13
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
5LX5
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BU of 5lx5 by Molmil
CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP.
Descriptor: DIPHOSPHATE, Nicotinamide phosphoribosyltransferase, [(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-5-[[[4-[6-(ethylamino)-5-(2-piperidin-1-ylethylcarbamoyl)pyridin-2-yl]-2-fluoranyl-phenyl]carbamoylamino]methyl]pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Bertrand, T, Marquette, J.P.
Deposit date:2016-09-20
Release date:2017-10-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP
To Be Published

227561

數據於2024-11-20公開中

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